Treatment of pediatric myelodysplastic syndromes and juvenile myelomonocytic leukemia: the Brazilian experience in the past decade

Background: Therapy strategies for myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) vary considerably. Objective: To review the treatment of Brazilian children who were diagnosed with MDS or JMML in the past decade and reported to the Brazilian Cooperative Group on Pediatric Myelodysplastic syndromes (BCG-MDS-PED). Results: of 173 children reported to the BCG-MDS-PED from January 1997 to January 2003 with a suspected diagnosis of MDS or JMML, 91 had the diagnosis confirmed after central review of the bone marrow aspirate and biopsy. Information on previous treatments was available for 78 MDS/JMML patients. Treatment varied from different schedules of low-dose (14%) and standard-dose chemotherapy (50%), granulocyte-colony-stimulating factor (G-CSF 7%), interferon (5%), steroids (2%) and erythropoietin (2%) to allogeneic stem-cell transplantation (SCT) (14%). No survival advantage could be demonstrated based on Hasle's classification or based on treatment. Conclusion: This report reflects the current practice in treating Brazilian children with MDS/JMML without specific Cooperative Group guidelines. Treatment modalities were very heterogeneous. The strategies for implementing a national protocol should consider international guidelines and focus on local experience and available resources. (C) 2004 Elsevier Ltd. All rights reserved.

Neonatal meningitis according to the microbiological diagnosis: a decade of experience in a tertiary center

The aim of this study was to evaluate the incidence of and mortality due to meningitis and compare data according to microbiological diagnosis. This was a ten-year retrospective study conducted at a neonatal intensive care unit (NICU). Newborns with meningitis confirmed by positive CSF culture were included; those with congenital infection or malformations that made lumbar puncture impossible were excluded. The variables investigated were birth weight, gestational and postnatal age, procedures, hematological and CSF parameters, and complications. Parametric and non-parametric tests were used (statistical value p<0.05). The incidence of meningitis was 0.6% and mortality was 27%. of the 22 cases, 59% involved Gram-negative bacteria; 36% Gram-positive and 5% fungi. The groups did not differ in relation to birth weight, gestational and postnatal age, procedures or hematological and CSF parameters. Sepsis, convulsions and deaths were frequent in both groups, without statistical difference. Gram-negative cases showed abscesses and higher frequency of ventriculitis and hydrocephaly. Meningitis was infrequent, but presented high mortality and frequent complications.

Latin America and the Caribbean in the World Economy 2010-2011: The region in the decade of the emerging economies

Incluye Bibliografía

A decade of light and shadow: Latin America and the Caribbean in the 1990s

Includes bibliography

A decade of social development in Latin America, 1990-1999

Includes bibliography

Strategy for the Caribbean countries during the Third Development Decade

Includes bibliography

Necesidades financieras del Decenio Internacional del Agua Potable y del Saneamiento Ambiental en América Latina = Financial demands of the International Drinking Water Supply and Sanitation Decade in Latin America

Incluye Bibliografía

Decenio Internacional del Agua Potable y del Saneamiento Ambiental: la situación en América Latina al comenzar el Decenio y las perspectivas para el futuro = International Drinking Water Supply and Sanitation Decade: the situation in Latin America on the eve of the decade and the prospects for the future

Incluye Bibliografía

Wage inequality in Latin America: a decade of changes

Includes bibliography

A decade of light and shadow: Latin America and the Caribbean in the 1990s

Includes bibliography

América Latina y el Segundo Decenio de las Naciones Unidas para el Desarrollo = Latin America and the Second Development Decade

Incluye Bibliografía

Avances hacia el logro de los objetivos del Decenio Internacional del Agua Potable y del Saneamiento Ambiental, 1980-1983 = Progress towards achievement of the goals of the International Drinking Water Supply and Sanitation Decade (IDWSSD), 1980-1983

Incluye Bibliografía

Aprovechamiento de los recursos hídricos: progresos realizados en la aplicación del Plan de Acción de Mar del Plata y el Decenio Internacional del Agua Potable y del Saneamiento Ambiental en América Latina y el Caribe = Water resource development: progress in the implementation of the Mar del Plata Action Plan and the International Drinking Water Supply and Sanitation Decade in Latin America and the Caribbean

Incluye Bibliografía

Estrategia Internacional de Desarrollo para el Segundo Decenio de las Naciones Unidas para el Desarrollo = International Development Strategy for the Second United Nations Development Decade

Incluye Bibliografía