Dornase alfa improves the health-related quality of life among Brazilian patients with cystic fibrosis - A one-year prospective study

Background: Health-related quality of life (HRQOL) measurements provide valuable information about the psychological and social impact of treatment on patients with cystic fibrosis (CF). This study evaluated the HRQOL of Brazilian patients with CF and assessed the changes in HRQOL domains over 1 year after dornase alfa (Pulmozyme) introduction. Patients and Methods: One hundred fifty-six stable patients with CF and 89 caregivers answered the Portuguese-validated version of the Cystic Fibrosis Questionnaire-Revised (CFQ-R) at baseline (T 0), and at 3 (T 1), 6 (T 2), 9 (T 3), and 12 (T 4) months of follow-up. Eighteen patientswere excluded because they did not fulfill the inclusion criteria. The patients were analyzed in two groups: those aged 6-11 years and those aged 14 years and older. ANOVA for observed repeated results and the last observation carried forward (LOCF) method for missing data were used for the statistical analysis. Results: After 1 year of follow-up, there was significant improvement in respiratory symptoms (T 4-T 0=8.1; 95% confidence interval (95% CI)=[2.1;14.0]; effect size (ES)=0.35; P<0.001), Emotional Functioning (T 4-T 0=5.6; 95% CI=[1.1;10.1]; ES=0.31; P<0.05), Social Functioning (T 4-T 0=6.0; 95% CI=[1.3;11.7]; ES=0.31; P<0.05), Body Image (T 4-T 0=11.9; 95% CI=[4.1;19.7]; ES=0.42; P<0.05), and Treatment Burden (T 4-T 0=5.3; 95% CI=[0.3;10.3]; ES=0.24; P<0.05) domains in the younger group. A significant improvement in Role Functioning (T 4-T 0=6.1; 95% CI=[1.1;11.1]; ES=0.40; P<0.05), Body Image (T 4-T 0=12.6; 95% CI=[3.5;21.7]; ES=0.46; P<0.05), and Weight (T 4-T 0=11.7; 95% CI=[1.8;21.6]; ES=0.40; P<0.05) was obtained in the older group. The caregivers' CFQ-R showed improvements in the Digestive Symptoms (T 4-T 0=5.5; 95% CI=[1.5;9.4]; ES=0.30; P<0.05), Respiratory Symptoms (T 4-T 0=7.6; 95% CI=[3.9;11.4]; ES=0.48; P<0.05), and Weight (T 4-T 0=10.1; 95% CI=[1.6;18.6]; ES=0.26; P<0.05) domains. Conclusion: The introduction of dornase alfa improved the HRQL of the patients with CF during the first year of treatment. © 2010 Wiley-Liss, Inc.

Capacitação de agentes multiplicadores para a semana da água 2005: concepções e práticas de educação ambiental

Pós-graduação em Educação - IBRC

Com que corpo eu vou?: a beleza e a performance na construção do corpo midiático

Pós-graduação em Ciências da Motricidade - IBRC

Práticas pedagógicas de professoras em classes multisseriadas: uma contribuição para a atuação docente no ciclos de alfabetização

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação e intervenção de bebês em instituição de acolhimento infantil

O presente estudo aborda a avaliação e intervenção com bebês em uma instituição de acolhimento infantil na cidade de Belém-Pa, através da aplicação da Escala de Desenvolvimento do Comportamento da Criança – EDCC e de um programa de atividades elaborado pela pesquisadora para a estimulação precoce/essencial das habilidades motoras, cognitivas, linguagem e afetivas. Dados referentes à história pregressa de todas as crianças envolvidas no estudo também foram considerados e obtidos por meio de relatos informais da equipe da instituição de acolhimento e através de documentos (prontuários) junto à direção. Participaram do estudo quatro bebês, com idade entre seis a onze meses, que não apresentavam disfunções neurológicas e com o maior tempo de permanência na instituição. A abordagem metodológica utilizada foi qualitativa, com característica descritiva e interventiva de pesquisa. A avaliação com a utilização da EDCC no período pré-intervenção demonstrou que todos os bebês participantes da pesquisa obtiveram a pontuação “4” referente a classificação “bom” da escala, sendo que inicialmente apresentaram dificuldades na realização de comportamentos que envolvem a linguagem e a interação social. Na reavaliação, a maioria dos bebês participantes manteve a pontuação “4” com apenas um evoluindo para “5” (excelente), visto que obtiveram melhora significativa nos comportamentos que exigiam a interação com outra pessoa. Assim como através do programa de estimulação, as crianças evoluíram na aquisição das habilidades motoras e afetivo-sociais. Os bebês passaram a demonstrar comportamentos como olhar nos olhos, sorrisos, reconhecimento do rosto do adulto, vocalizações, entre outros. Isto evidenciou que o contexto de acolhimento pode ser um fator de proteção para a infância que encontra-se em situação de vulnerabilidade. Por fim, propõe-se que estudos futuros possam reconhecer a importância da avaliação do desenvolvimento infantil em contextos institucionais e de propostas de estimulação que possam ser incorporadas no cotidiano desses ambientes.

Desenvolvimento comportamental manipulativo e ocorrência de olhar mútuo entre macacos-prego (Cebus cf. apella) em cativeiro

Os filhotes de Cebus durante os dois primeiros meses de vida, dependem quase que exclusivamente de sua mãe. Só a partir do terceiro mês o filhote passa a se locomover independentemente, e é nesse período que corre uma importante mudança no seu padrão comportamental, pois há um aumento em seu repertório manipulativo. O principal objetivo desse estudo foi acompanhar o desenvolvimento do comportamento manipulativo em três filhotes de Cebus cf. apella e verificar a possível preferência pelo olhar mútuo entre macacos-prego. No Experimento 1, com o método de animal focal foi medida a freqüência de linha de base das categorias comportamentais de três Cebus cf. apella filhotes, e em seguida inseridos quatro tipos de objetos, um a cada semana, para o acesso ao desenvolvimento de comportamentos manipulativos. No Experimento 2, foi realizado teste de discriminação simples, usando como estímulos fotos de macacos-prego com diferentes direções do olhar. No Experimento 3, foi realizado um treino de discriminação simples, com dois pares de estímulos: rosto frontal e olhar direto versus desviado e rosto de frente versus de perfil. Os resultados demonstram que os filhotes de mesma faixa etária despenderam tempo semelhante manipulando objetos. Não foi possível observar um padrão claro quanto a preferência em observar imagens com olhar direto ou desviado (Experimento 2). Os sujeitos foram capazes de discriminar a direção do olhar no Experimento 3.

Jogo de papéis e linguagem: diálogos possíveis entre Vigotski e Bakhtin

In this paper we present ongoing research in which we approach the regulatory role of language in role play in children aged six and seven. In research, we seek an understanding of the relationship between language, ownership and complexity of the children's game. The hypothesis guiding the research is that the dialogical relations between children and adults and among children, while playing, contribute to children's learning game. Procedures are being used interpretive ethnographic research that focuses on the human meaning of social relations, waged by the subjects in a particular historical context and its elucidation and exposition by one researcher. This approach allows closer studies of Vygotsky and Bakhtin scholars of language that emphasize the regulatory role of language in human relationships and value the dialogic exchange between researcher and researched; active subjects of the research process. The data were produced by means of observation and interview, in a field diary records, photographs and audio recordings. They are being screened in thematic groups and analyzed using interpretative narration. The participants were two teachers and two classes of the first year of an Elementary school (EMEF) School of Municipal Elementary School Crane, State of Sao Paulo, totaling 45 subjects. Bearing in mind the above assumptions, are presented and analyzed data that allow to anticipate some results.

Acompanhamento psicológico de criança com problema de sono: um relato de caso

Difficulties with sleep are frequent in the pre-schooler children. The aim of this study was to present a case report of behavioural intervention by parental guidance to sleeping problems in a pre-schooler child. Participated in this study a four years old boy that had difficulties to sleep without the presence of his parents and his mother who was oriented through a parental program. The program of intervention was composed by five sessions in which the mother acquired education about the child’s sleep, received orientation about the establishment of time and routine to sleep and about the use of techniques (extinction and positive reinforcement) for the improvement of the sleep difficulties. The sleep and behaviour were evaluated in four periods (pre-treatment, post-treatment, one and six months follow up) according to the following instruments: 1) UNESP Scale of Habits and Hygiene of the Sleep – Children Version, 2) Scale of Sleep Disorders for Children and Teenagers, 3) Child Behavior Checklist (CBCL 1,5-5) and 4) sleep diary. The results showed that after intervention the child developed independent sleep, reduced the bed resistance and showed improvement in daily behaviors. To conclude: a behavioral intervention by parental guidance was effective to sleep problems of the child.

Impact of chronic stressors on the anxiety profile of pregnant rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Ensino de operantes verbais e requisitos para ensino por tentativas discretas em crianças com transtorno do espectro autista (TEA)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Caracterização das habilidades sociais de universitários

The entering at the University requires new social skills and their deficits may bring to students academic and interpersonal diffi culties. Few studies have addressed the infl uence of undergraduate periods and gender diff erences regarding social skills shown by college students, including frequency and quality which they occur and previous and consequent interaction variables. The main objective of this article is to describe the social skills shown by college students over undergraduate years. For specifi c objectives this study intends (a) the comparison of student groups in diff erent years (fi rst/second; fi rst/third; second/third) of full-time and nocturne periods, of men and women and (b) the presentation of functional analysis of interactions, considering the most frequent behaviors and contexts. For that, 85 students of Design course were analyzed through the following instruments: the Social Skills Questionnaire to College Students, Behaviors and Contexts; and the Social Skills Inventory (SSI). The results indicate diff erences between men and women and between full-time students and nocturne ones, and the greatest diff erences were in comparison between years, indicating that the fi rst and second years require greater investments in interventions, because they present greater diffi culties in communication behaviors, expressiveness and confl ict resolution. Furthermore, implications, limitations and suggestions for research are discussed.

A língua portuguesa no 5º ano do ensino fundamental: repertórios de ensino no contexto da Prova Brasil/ SAEB

Pós-graduação em Psicologia do Desenvolvimento e Aprendizagem - FC

Niche Specialization and Conservation Biology of Cicindela nevadica lincolniana

As with many organisms across the globe, Cicindela nevadica lincolniana is threatened with extinction. Understanding ecological factors that contribute to extinction vulnerability and what methods aid in the recovery of those species is essential in developing successful conservation programs. Here we examine behavioral mechanisms for niche partitioning along with improving techniques for captive rearing protocol and increasing public awareness about the conservation of this local insect. Ovipositional selectivity was examined for Cicindela nevadica lincolniana, Cicindela circumpicta, Cicindela togata, Cicindela punctulata, and Cicindela fulgida. Models reflect that these species of co-occurring tiger beetles select different ranges of salinity in which to oviposit thereby reducing the potential for interspecific competition. In a second study, thermoregulatory niche partitioning was examined for the same complex of tiger beetle species. Time spent in the sun, on different substrates, and engaging in various behaviors associated with thermoregulation were significantly different during different parts of the day and between species. I continued along a previous line of study to develop a viable captive rearing program. So far fourteen adult Cicindela nevadica lincolniana have been successfully reared in captivity. Overwintering mortality has been determined as a key factor in the mortality of this species in captivity. Finally, I examined the potential for using the visual arts to promote the conservation of Cicindela nevadica lincolniana and associated saline wetlands. The results from surveys conducted at the exhibit suggest that art exhibits can have a strong positive impact on members of the community.

La coazione all'adempimento mediante la tecnica delle misure coercitive indirette

La tesi intende offrire una riflessione in merito all’utilizzo della tecnica delle misure coercitive indirette quali strumenti di coartazione della volontà dell’obbligato al fine di indurlo all’esatto adempimento in presenza di statuizioni giudiziali il cui contenuto si sostanzi in prestazioni a carattere infungibile o in un dovere di astensione dal porre in essere determinati comportamenti, che non possono trovare esecuzione secondo le ordinarie forme previste dal Libro Terzo del Codice di procedura civile. Il lavoro prende le mosse dall'analisi storico-comparatistica dello sviluppo dell'esecuzione processuale indiretta nei principali ordinamenti giuridici europei, per poi soffermarsi sulle singole misure coercitive indirette disciplinate dal legislatore italiano nel corso degli anni al fine di far fronte alle esigenze di tutela emergenti in specifici settori del diritto. Segue un'attenta disamina in ordine alla disposizione di cui all'art. 614-bis c.p.c., con cui è stata introdotta per la prima volta nel nostro ordinamento una misura coercitiva indiretta a carattere generale in materia di esecuzione degli obblighi di fare infungibile e di non fare.

Do College Women Facilitate the Sexual Assault of Their Same-Gender Peers?

National studies indicate that approximately 25 percent of women have been sexually assaulted by the time they finish college. Although male peers are often the perpetrators, women also engage in behaviors with their female peers that may increase the risk of sexualassault. In the present study, we sought to determine how often college women engaged in these behaviors (i.e. “female facilitation”). Participants were 373 female students (sophomorethrough senior; Greek and independent) who completed an online survey containing measures of sexual assault, alcohol consumption, and female facilitation. The female facilitation measure indexed both “facilitator” behaviors (those directed toward others thatlikely increase the risk of sexual assault victimization) and “facilitatee” behaviors (those that may increase risk of sexual assault victimization), and the two sets of items werecounterbalanced across participants. Descriptive statistics showed an overall prevalence rate for any type of sexual assault was 44.2%. Scores on the facilitator and facilitatee versions ofthe female facilitation measure were highly correlated. Facilitation was highly correlated with alcohol consumption, and being a faciltatee was moderately correlated with sexual assault. Results were consistent with some of our expectations regarding the relationships among facilitation, alcohol consumption, sexual assault, and demographic variables. Limitations of the methods and the implications of the findings for understanding campussexual assault will be discussed.