Caracterização estrutural e das interações entre a Proteína G do hRSV e potenciais inibidores

Pós-graduação em Microbiologia - IBILCE

Perfil do líder comunitário da pastoral da criança da região norte da cidade de Londrina - PR

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da sensibilidade à insulina e transdução do sinal insulínico em ratos adultos, proles de ratas com doença periodontal

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

La reducción de la mortalidad infantil en América Latina y el Caribe: avance dispar que requiere respuestas variadas

La presente edición está dedicada al tema de la reducción de la mortalidad infantil en la región, lo cual se analiza de manera pormenorizada y con datos actualizados en el artículo central, constituyendo información estratégica para políticas e intervenciones a futuro. Manteniendo la línea editorial, incluye también un espacio para opiniones de adolescentes y jóvenes, así como de expertos en políticas, sobre el problema, causas y abordajes en relación a la mortalidad infantil. E información sucinta sobre una amplia gama de programas, en países de la región, en relación al cuidado infantil y materno infantil que redunda en reducción de la mortalidad.

Infrastructure, integration and equity: The social impact of the health and public transportation infrastructure.

Academicians and practitioners generally agree that there is a positive correlation between more and better infrastructure and economic growth. From the broader perspective of development, attempts have been made in the literature to identify the different theoretical connections and the empirical patterns that link infrastructure to productivity, on the one hand, and those that link it to social inclusion and equity, on the other hand. Infrastructure contributes to development in different ways. The capital involved is not homogeneous, nor is its effect on the distributive aspects. Water and sanitation have a particularly strong association with the health of the general population and with infant mortality, early childhood health, learning abilities and the acquisition of labour skills. With respect to transportation, the reduction of costs and travel times has a direct economic impact on economic activities of production and domestic and international distribution. That infrastructure also has a social and distributive role to play by reducing the number of fatal accidents and serious injuries in the sectors that are naturally most susceptible to them, namely, the poor. Under the broad umbrella of infrastructure, we can include a number of facilities that make possible the provision of certain services. Some of these facilities require very significant fixed capital investments; some of them are residential, while others are not necessarily. What they all have in common is the existence of networks (transportation, wiring, pipelines) and a strong convergence of physical capital and/or technology, as well as the need for major investments in periodic maintenance.

Proyecciones de población = Population projections

El Observatorio Demográfico 2014 contiene indicadores seleccionados de la revisión de 2014 de las estimaciones y proyecciones de la población analizada. Las cifras contenidas en esta publicación constituyen una revisión de las presentadas en el Observatorio 2013. En esta oportunidad, se actualizaron las estimaciones y proyecciones de la población a nivel nacional desde 1950 hasta 2100, considerando las nuevas fuentes de información disponibles. En las próximas ediciones se irán incorporando las nuevas estimaciones y proyecciones de población, elaboradas también con el método de los componentes, pero por edades simples y años calendario. Como es habitual, se incluye un capítulo en el que se analizan las tendencias demográficas. En esta ocasión, se examinan los avances en el descenso de la mortalidad infantil más allá de lo proyectado a fines de la década de 1980. Link a la base de datos de donde se obtiene esta información: http://www.cepal.org/es/estimaciones-proyecciones-poblacion-largo-plazo-1950-2100

Notas de Población Vol. 42 N° 101

La edición número 101 de Notas de Población contiene nueve artículos sobre temas de gran actualidad y relevancia futura en el campo de la investigación sociodemográfica en América Latina y el Caribe. La variada gama de asuntos que se abordan en la presente edición empieza con la aplicación del modelo de transición logística y las proyecciones de población, pasando por el análisis de la transición epidemiológica de la mortalidad infantil en América Latina y los determinantes de la fecundidad adolescente y su relación con la distribución territorial. Continúa con el envejecimiento, su relación con las condiciones de la vivienda, la migración calificada y el análisis del ciclo vital de las personas en relación con una esperanza de vida sana. Concluye con la percepción de la alteridad en la declaración del color y la raza en la encuesta de empleo del Brasil.

Panorama Económico y Social de la Comunidad de Estados Latinoamericanos y Caribeños, 2015

Este Panorama Económico y Social de la Comunidad de Estados Latinoamericanos y Caribeños es una contribución de la Comisión Económica para América Latina y el Caribe (CEPAL) a la Cuarta Cumbre de Jefes de Estado y de Gobierno de la Comunidad de Estados de América Latina y el Caribe (CELAC), (Quito, enero de 2016).

Economic and Social Panorama of the Community of Latin American and Caribbean States 2015

This edition of the Economic and Social Panorama of the Community of Latin American and Caribbean States is a contribution by the Economic Commission for Latin America and the Caribbean (ECLAC) to the fourth Summit of Heads of State and Government of the Community of Latin American and Caribbean States (CELAC), to be held in Quito in January 2016. This document continues the work carried out since the first summit of CELAC held in Santiago and is a testimony to our ongoing commitment to work in collaboration with the countries of the region.

High incidence of preventable deaths during childhood in Porto Velho, Rondonia - Brazil

Background: We aimed to estimate and analyze epidemiological profile of deaths during childhood. Method: We used the databases of deaths provided by Information System of mortality between 2006 and 2010. We selected only those records where the occurrence of deaths corresponded to Porto Velho city and those who were aged between 12 and 48 months old at the moment of death. We examined only deaths from preventable causes and poorly defined. Results: The total number of deaths was estimated to be 103, 48.6% male. High frequencies of deaths occurred (39.8%) in children before reaching two years old. Vast majority of deaths (66.9%) was due to preventable causes, 18.4% by poorly defined causes and nearly one in three by external causes. Approximately one in four were due to traffic accidents, 41.9% by drowning and submersion. Also, there were significant frequencies of deaths associated with respiratory diseases (17.5%) and infectious and parasitic diseases (16.6%). Conclusion: These findings reinforce the importance of studies of infant mortality, drawing attention to the debate on policy design to reduce childhood deaths, especially in acting on preventable causes.

Perfil materno e dos recém-nascidos nascidos vivos na primeira década do século XXI em município do interior paulista com ênfase na prematuridade

The concern with infant mortality has been a priority in public policies, especially for Brazil to achieve the Millennium Development Goal number four: reducing child mortality by 75% by the year 2015. It is known that prematurity has an intimate relationship with mortality of children under one year and therefore it is necessary an effective intervention in risk factors linked to premature births. To evaluate the profile of mothers and newborn babies living in Botucatu-SP, in the period 2001 to 2009, focusing on prematurity. A quantitative study, retrospective, descriptive, epidemiological, from the Information System Newborn Alive. The prevalence of preterm births was 15.1%, and low birth weight 14.7%. Among infants, the Apgar score below 7 at 1 and at 5 minutes was 13.1% and 2.4% respectively. Considering the total of pregnant women studied, 20.3% were adolescents and 10.3% were aged 35 years or more and most (63.2%) had eight or more years of school approval. The profile of mothers of premature infants shows that 23.6% were teenagers, 14.1% had at least 35 years and 60.4% had at least primary education. With regard to premature deliveries, caesarean sections and 58.4% were between the total newborns, this type of delivery was achieved in 46.6% of cases. Prematurity was associated with an Apgar score below seven in the first and fifth minutes of life, presence of malformation and multiple pregnancy. Among maternal variables, prematurity was associated with extremes of maternal age, maternal education, history of stillbirth, primiparas, white and presence of the mother's partner. With regard to delivery was associated with cesarean section and outside the hospital. This study assessed maternal characteristics associated with prematurity and point out how relevant the pregnancies at the extremes of age and those that occur in women with low education level, indicating the interference... (Complete abstract click electronic access below)

Incidência, fatores de risco e consequências de defeitos congênitos em recém-nascidos e natimortos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ineraction Model Between HRSV G-Protein and Flavonoids

Background: Acute respiratory infections (ARI) are the leading cause of infant mortality in the world, and human respiratory syncytial virus (HRSV) is one of the main agents of ARI. One of the key targets of the adaptive host immune response is the RSV G-protein, which is responsible for attachment to the host cell. There is evidence that compounds such as flavonoids can inhibit viral infection in vitro. With this in mind, the main purpose of this study was to determine, using computational tools, the potential sites for interactions between G-protein and flavonoids. Results: Our study allowed the recognition of an hRSV G-protein model, as well as a model of the interaction with flavonoids. These models were composed, mainly, of -helix and random coil proteins. The docking process showed that molecular interactions are likely to occur. The flavonoid kaempferol-3-O-α-L-arabinopyranosil-(2 → 1)-α-L-apiofuranoside-7-O-α-L-rhamnopyranoside was selected as a candidate inhibitor. The main forces of the interaction were hydrophobic, hydrogen and electrostatic. Conclusions: The model of G-protein is consistent with literature expectations, since it was mostly composed of random coils (highly glycosylated sites) and -helices (lipid regions), which are common in transmembrane proteins. The docking analysis showed that flavonoids interact with G-protein in an important ectodomain region, addressing experimental studies to these sites. The determination of the G-protein structure is of great importance to elucidate the mechanism of viral infectivity, and the results obtained in this study will allow us to propose mechanisms of cellular recognition and to coordinate further experimental studies in order to discover effective inhibitors of attachment proteins.

Itinerário terapêutico de mães de crianças que foram a óbito no período neonatal em município do interior paulista

Pós-graduação em Enfermagem - FMB

Variáveis de impacto na queda da mortalidade infantil no Estado de São Paulo, Brasil, no período de 1998 a 2008

This is an ecological, analytical and retrospective study comprising the 645 municipalities in the State of Sao Paulo, the scope of which was to determine the relationship between socioeconomic, demographic variables and the model of care in relation to infant mortality rates in the period from 1998 to 2008. The ratio of average annual change for each indicator per stratum coverage was calculated. Infant mortality was analyzed according to the model for repeated measures over time, adjusted for the following correction variables: the city's population, proportion of Family Health Programs (PSFs) deployed, proportion of Growth Acceleration Programs (PACs) deployed, per capita GDP and SPSRI (Sao Paulo social responsibility index). The analysis was performed by generalized linear models, considering the gamma distribution. Multiple comparisons were performed with the likelihood ratio with chi-square approximate distribution, considering a significance level of 5%. There was a decrease in infant mortality over the years (p < 0.05), with no significant difference from 2004 to 2008 (p > 0.05). The proportion of PSFs deployed (p < 0.0001) and per capita GDP (p < 0.0001) were significant in the model. The decline of infant mortality in this period was influenced by the growth of per capita GDP and PSFs.