Leviathan oder Rabbinen und Juden : mehr als kom. Roman u. doch Wahrheit ; voll d. kurzweiligsten Erzählungen u. doch Ernst ; Parascha 1-3

vom Verf. d. Behemoth [d.i. Andreas Riem]

Projet de réglement concernant la circoncision, suivi d'observations sur une lettre pastorale du Grand-Rabbin de Metz et sur un écrit de Lazare (aineé)

par Tsarphati [d.i. Olry Terquem]

Herr Otto Hartmann in Köln und sein Kampf gegen die Schlachtweise der Israeliten : den verehrl. Mitgliedern d. Thierschutzvereine gewidmet

von einem Collegen [d.i. Leopold Hamburger]

Endogenous and synthetic MMP inhibitors in CNS physiopathology.

Matrix metalloproteinases (MMPs, including the membrane-type MMPs (MT-MMPs)), a disintegrin and metalloproteinase (ADAM), and ADAM with thrombospondin motifs belong to the metzincins, a subclass of metalloproteinases that contain a Met residue and a Zn(2+) ion at the catalytic site necessary for enzymatic reaction. MMP proteolytic activity is mainly controlled by their natural tissue inhibitors of metalloproteinase (TIMP). A number of synthetic inhibitors have been developed to control deleterious MMP activity. The roles of MMPs and some of their ECM substrates in CNS physiology and pathology are covered by other chapters of the present volume and will thus not be addressed in depth. This chapter will focus (i) on the endogenous MMP inhibitors in the CNS, (ii) on MMP and TIMP regulations in three large classes of neuropathologic processes (inflammatory, neurodegenerative, and infectious), and (iii) on synthetic inhibitors of MMPs and the perspective of their use in different brain diseases.

Les Juifs de Russie : recueil d'articles et d'études sur leur situation légale, sociale et économique

[Mitarb.: E. B. Lanin, d.i. Valentine Dillon]

The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis.

BACKGROUND High mortality and morbidity rates are observed in patients with bacterial meningitis (BM) and urge for new adjuvant treatments in addition to standard antibiotic therapies. In BM the hippocampal dentate gyrus is injured by apoptosis while in cortical areas ischemic necrosis occurs. Experimental therapies aimed at reducing the inflammatory response and brain damage have successfully been evaluated in animal models of BM. Fluoxetine (FLX) is an anti-depressant of the selective serotonin reuptake inhibitors (SSRI) and was previously shown to be neuroprotective in vitro and in vivo. We therefore assessed the neuroprotective effect of FLX in experimental pneumococcal meningitis. METHODS Infant rats were infected intracisternally with live Streptococcus pneumoniae. Intraperitoneal treatment with FLX (10mgkg(-1)d(-1)) or an equal volume of NaCl was initiated 15min later. 18, 27, and 42h after infection, the animals were clinically (weight, clinical score, mortality) evaluated and subject to a cisternal puncture and inflammatory parameters (i.e., cyto-/chemokines, myeloperoxidase activity, matrix metalloproteinase concentrations) were measured in cerebrospinal fluid (CSF) samples. At 42h after infection, animals were sacrificed and the brains collected for histomorphometrical analysis of brain damage. RESULTS A significant lower number of animals treated with FLX showed relevant hippocampal apoptosis when compared to littermates (9/19 animals vs 18/23, P=0.038). A trend for less damage in cortical areas was observed in FLX-treated animals compared to controls (13/19 vs 13/23, P=ns). Clinical and inflammatory parameters were not affected by FLX treatment. CONCLUSION A significant neuroprotective effect of FLX on the hippocampus was observed in acute pneumococcal meningitis in infant rats.

R&D on crystalline silicon technology: From metallurgical silicon to the PV module

Founded by Antonio Luque in 1979 Personnel: Personnel: 6464 full full-time time staff (19 professors staff (19 professors, 44 PhD PhD researchers 28 PhD students 13 researchers, 28 PhD students, 13 administrative and maintenance staff), 19 “part time” (11 “external PhD students”, 8 master students) Objective: Objective: Contribute to the deployment of Photovoltaic Solar Electricity through R&D& Contribute to the deployment of Photovoltaic Solar Electricity through R&D&i

Atmospheric modelling of tritium forms transport: review of capabilities and R&D needs for the assessment of fusion facilities environmental impact

One of the key scrutiny issues of new coming energy era would be the environmental impact of fusion facilities managing one kg of tritium. The potential change of committed dose regulatory limits together with the implementation of nuclear design principles (As Low as Reasonably achievable - ALARA -, Defense in Depth -D-i-D-) for fusion facilities could strongly impact on the cost of deployment of coming fusion technology. Accurate modeling of environmental tritium transport forms (HT, HTO) for the assessment of fusion facility dosimetric impact in Accidental case appears as of major interest. This paper considers different short-term releases of tritium forms (HT and HTO) to the atmosphere from a potential fusion reactor located in the Mediterranean Basin. This work models in detail the dispersion of tritium forms and dosimetric impact of selected environmental patterns both inland and in-sea using real topography and forecast meteorological data-fields (ECMWF/FLEXPART). We explore specific values of this ratio in different levels and we examine the influence of meteorological conditions in the HTO behavior for 24 hours. For this purpose we have used a tool which consists on a coupled Lagrangian ECMWF/FLEXPART model useful to follow real time releases of tritium at 10, 30 and 60 meters together with hourly observations of wind (and in some cases precipitations) to provide a short-range approximation of tritium cloud behavior. We have assessed inhalation doses. And also HTO/HT ratios in a representative set of cases during winter 2010 and spring 2011 for the 3 air levels.

Mg-chelatase of tobacco: The role of the subunit CHL D in the chelation step of protoporphyrin IX

The Mg-chelation is found to be a prerequisite to direct protoporphyrin IX into the chlorophyll (Chl)-synthesizing branch of the tetrapyrrol pathway. The ATP-dependent insertion of magnesium into protoporphyrin IX is catalyzed by the enzyme Mg-chelatase, which consists of three protein subunits (CHL D, CHL I, and CHL H). We have chosen the Mg-chelatase from tobacco to obtain more information about the mode of molecular action of this complex enzyme by elucidating the interactions in vitro and in vivo between the central subunit CHL D and subunits CHL I and CHL H. We dissected CHL D in defined peptide fragments and assayed for the essential part of CHL D for protein–protein interaction and enzyme activity. Surprisingly, only a small part of CHL D, i.e., 110 aa, was required for interaction with the partner subunits and maintenance of the enzyme activity. In addition, it could be demonstrated that CHL D is capable of forming homodimers. Moreover, it interacted with both CHL I and CHL H. Our data led to the outline of a two-step model based on the cooperation of the subunits for the chelation process.

Letter from Charles Stewart to his brother-in-law, William Tudor,

This letter was written aboard the U.S.S. Franklin. Stewart writes in detail about William’s brother Henry James (Harry) Tudor, and concerns about his character, particularly his "natural indolence and indifference." He notes that like his wife, Delia, Harry spends money irresponsibly. Stewart also writes he tried to interest Harry in the pursership of the Franklin, and had hoped he would be appointed to the Consulate of Tripoli or Tunis.

Letters from William Tudor to his father, William Tudor,

Two undated letters written while Tudor was traveling to Washington, D.C., which include news of friends and his general impressions of the atmosphere and economy of the capital. He also comments on President Thomas Jefferson’s informal manner of greeting visitors: "The present administration leaving the childish etiquette of the last have gone into the other extreme.... he receives the foreign ministers in his slippers."

Letter from A. Dickason to Delia Tudor Stewart,

Letter from an A. Dickason in London addressing Delia’s health and spirits. Also included are notes to Delia and her sister Emma from both "A.D." and "M.D."

Almanac, annotated, 1745

Interleaved copy of Nathaniel Ames’ An Astronomical Diary: or, An Almanack for the Year of our Lord Christ, 1745 ... (Boston, 1745) annotated by Andrew Bordman II with regular entries about the weather, and occasional community news. Copy mutilated with some text missing.

Tolkovyĭ slovarʹ zhivago velikoruskago i��azyka /

"Pechatano na schet Vsemilostivi��eĭshe pozhalovannykh sredstv."--T.p., Vol.2-4.

Fantaisie brillante, sur la Marche et la Romance d'Otello de Rossini : pour le violon avec accompt. d'orchestre ou de quatour ou de piano, et une partie de piano, remplaçant des instruments à vent, op. 11 /

Mode of access: Internet.