The INTERNORM project : bridging two worlds of expert- and layknowledge in standardization

This paper presents a pilot project to reinforce participatory practices in standardization. The INTERNORM project is funded by the University of Lausanne, Switzerland. It aims to create an interactive knowledge center based on the sharing of academic skills and the experiences accumulated by the civil society, especially consumer associations, environmental associations and trade unions to strengthen the participatory process of standardization. The first objective of the project is action-oriented: INTERNORM provides a common knowledge pool supporting the participation of civil society actors to international standard-setting activities by bringing them together with academic experts in working groups and by providing logistic and financial support to their participation to meetings of national and international technical committees. The second objective of the project is analytical: the standardization action initiated through INTERNORM provides a research field for a better understanding of the participatory dynamics underpinning international standardization. The paper presents three incentives that explain civil society (non-)involvement in standardization that try to overcome conventional resource-based hypotheses: an operational incentive, related to the use of standards in the selective goods provided by associations to their membership; a thematic incentive, provided by the setting of priorities by strategic committees created in some standardization organization; a rhetorical incentive, related to the discursive resource that civil society concerns offers to the different stakeholders.

EORTC-ROG expert opinion: radiotherapy volume and treatment guidelines for neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction and the stomach.

PURPOSE: The Gastro-Intestinal Working Party of the EORTC Radiation Oncology Group (GIWP-ROG) developed guidelines for target volume definition in neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction (GEJ) and the stomach. METHODS AND MATERIALS: Guidelines about the definition of the clinical target volume (CTV) are based on a systematic literature review of the location and frequency of local recurrences and lymph node involvement in adenocarcinomas of the GEJ and the stomach. Therefore, MEDLINE was searched up to August 2008. Guidelines concerning prescription, planning and treatment delivery are based on a consensus between the members of the GIWP-ROG. RESULTS: In order to support a curative resection of GEJ and gastric cancer, an individualized preoperative treatment volume based on tumour location has to include the primary tumour and the draining regional lymph nodes area. Therefore we recommend to use the 2nd English Edition of the Japanese Classification of Gastric Carcinoma of the Japanese Gastric Cancer Association which developed the concept of assigning tumours of the GEJ and the stomach to anatomically defined sub-sites corresponding respectively to a distinct lymphatic spread pattern. CONCLUSION: The GIWP-ROG defined guidelines for preoperative irradiation of adenocarcinomas of the GEJ and the stomach to reduce variability in the framework of future clinical trials.

Genetic Variations and Diseases in UniProtKB/Swiss-Prot: The Ins and Outs of Expert Manual Curation.

During the last few years, next-generation sequencing (NGS) technologies have accelerated the detection of genetic variants resulting in the rapid discovery of new disease-associated genes. However, the wealth of variation data made available by NGS alone is not sufficient to understand the mechanisms underlying disease pathogenesis and manifestation. Multidisciplinary approaches combining sequence and clinical data with prior biological knowledge are needed to unravel the role of genetic variants in human health and disease. In this context, it is crucial that these data are linked, organized, and made readily available through reliable online resources. The Swiss-Prot section of the Universal Protein Knowledgebase (UniProtKB/Swiss-Prot) provides the scientific community with a collection of information on protein functions, interactions, biological pathways, as well as human genetic diseases and variants, all manually reviewed by experts. In this article, we present an overview of the information content of UniProtKB/Swiss-Prot to show how this knowledgebase can support researchers in the elucidation of the mechanisms leading from a molecular defect to a disease phenotype.

Catalogue de la collection de tableaux... provenant du cabinet de M. [Louis] Cournerie,... / [expert] Cournerie

[Vente. Art. 1856-11-19. Paris]

Tableaux et dessins anciens et modernes : collection de M. Véron / [expert] Francis Petit

[Vente. Art. 1858-03-18. Paris]

Catalogue d'estampes des diverses écoles... / [expert] Vignères

[Vente. Estampes. 1858-04-10. Paris]

Catalogue de tableaux modernes, dessins... provenant du cabinet de monsieur le docteur F***... / [expert] Francis Petit

[Vente. Art. 1858-04-10. Paris]

Catalogue d'estampes anciennes et modernes... par suite du décès de M. J. [Jean] Bein... vente... 26 avril 1858 / [expert] Vignères

[Vente. Estampes. 1858-04-26. Paris]

Catalogue de tableaux et dessins modernes... / [expert] Francis Petit

[Vente. Art. 1859-02-26. Paris]

Catalogue des tableaux, vues d'Orient et autres par M. Louis Lottier... / [expert] Ch. Rouillard

[Vente. Art. 1859-03-03. Paris]

Notice d'estampes d'artistes... après décès de M. P.-F. Quénard,... / [expert] Vignères

[Vente. Estampes. 1859-04-26. Paris]

Catalogue de la première partie de la belle collection de tableaux anciens... composant la galerie de feu M. le comte de Houdetot,... / [expert] Ferdinand Laneuville

[Vente. Art. 1859-12-12 - 1859-12-14. Paris]

Catalogue des tableaux modernes composant la collection de M. le baron C***... [Courtier] / [expert] A. Couteaux

[Vente. Art. 1860-01-25. Paris]

Catalogue d'une belle collection de tableaux modernes... / [expert] A. Couteaux

[Vente. Art. 1860-03-07. Paris]

Catalogue de miniatures..., tableaux... provenant du cabinet de M. W... [Walferdin] / [expert] Vignères

[Vente. Art. 1860-05-18. Paris]