Identification of a new calcitonin gene in the salmon Oncorhynchus gorbuscha.

Three isoforms of calcitonin (CT) exist in salmonids. Isohormones I and II are expressed in the pink salmon Oncorhynchus gorbuscha. We report here the existence in this species of a CT gene and of its transcripts, which encode for a fourth isohormone, the salmon CT (sCT) IV. This new CT gene was identified by PCR from genomic DNA and by sequencing the amplified DNA. The expression of this CT gene was established in ultimobranchial body and brain, by reverse transcription-PCR, hybridization and sequencing. The sCT IV gene, like the sCT I gene, is a complex transcription unit, containing exons encoding for a CT as a calcitonin gene-related peptide (CGRP) molecule. The predicted peptide, sCT IV, has a greater homology with the eel CT and the sCT II than with the sCT I. Alignment of the sCT IV with other fish and chicken CT showed amino acid modifications in similar positions as those found during evolution. The predicted salmon CGRP IV peptide is highly homologous to the known CGRP molecules in other species, confirming the high conservation of the molecule during evolution. This identification of a new salmon CT gene is interesting both for the therapeutic potential represented by the new molecules encoded by this gene and for phylogenetic studies.

Bond of Samuel Shapleigh and Thomas Adams to the Harvard Corporation, Aug. 15, 1789

Shapleigh and Adams' signatures have been cut out from the bottom of this document. It was "signed, sealed and delivered" in the presence of Thomas Gray and Darius Shaw.

Temperature measured in permafrost borehole at ICDP site 5011-3 in El'gygytgyn Crater, 2008-2011

This study focuses on the temperature field observed in boreholes drilled as part of interdisciplinary scientific campaign targeting the El'gygytgyn Crater Lake in NE Russia. Temperature data are available from two sites: the lake borehole 5011-1 located near the center of the lake reaching 400 m depth, and the land borehole 5011-3 at the rim of the lake, with a depth of 140 m. Constraints on permafrost depth and past climate changes are derived from numerical simulation of the thermal regime associated with the lake-related talik structure. The thermal properties of the subsurface needed for these simulations are based on laboratory measurements of representative cores from the quaternary sediments and the underlying impact-affected rock, complemented by further information from geophysical logs and data from published literature. The temperature observations in the lake borehole 5011-1 are dominated by thermal perturbations related to the drilling process, and thus only give reliable values for the lowermost value in the borehole. Undisturbed temperature data recorded over more than two years are available in the 140 m deep land-based borehole 5011-3. The analysis of these observations allows determination of not only the recent mean annual ground surface temperature, but also the ground surface temperature history, though with large uncertainties. Although the depth of this borehole is by far too insufficient for a complete reconstruction of past temperatures back to the Last Glacial Maximum, it still affects the thermal regime, and thus permafrost depth. This effect is constrained by numerical modeling: assuming that the lake borehole observations are hardly influenced by the past changes in surface air temperature, an estimate of steady-state conditions is possible, leading to a meaningful value of 14 ± 5 K for the post-glacial warming. The strong curvature of the temperature data in shallower depths around 60 m can be explained by a comparatively large amplitude of the Little Ice Age (up to 4 K), with low temperatures prevailing far into the 20th century. Other mechanisms, like varying porosity, may also have an influence on the temperature profile, however, our modeling studies imply a major contribution from recent climate changes.

University of Michigan Men's Basketball Team, 1998

Back Row: ?, ?, Travis Conlan, Brandon Smith, Darius Taylor, Robbie Reid, ?,

Front Row: Ron Oliver, Jerod Ward, Josh Asselin, Robert Traylor, Peter Vignier, Erik Szyndlar, Louis Bullock

University of Michigan Men's Basketball Team, 1998

L-R: Ron Oliver (25), Darius Taylor (10), Jerod Ward (32) Robbie Reid (3), Peter Vignier (55), Robert Traylor (54), Josh Asselin (25), Travis Conlan (21), Maceo Baston (30), Brandun Smith (34), Louis Bullock (11)

University of Michigan Men's Basketball Team, 1999

Back Row: asst. coach Scott Trost, asst. coach Kurtis Townsend, Leon Jones, Brandon Smith, Chris Young, Josh Asselin, Peter Vignier, Erik Szyndlar, Darius Taylor, coach Brian Ellerbe

Front Row: equip. mngr. Bob Bland, asst. coach Lorenzo Neely, Donte Scott, Robbie Reid, Louis Bullock, Ron Oliver, admin. assoc. Tom Sorboro, trainer Steve Stricker

University of Michigan Men's Basketball Team, 2000

Back Row: Assistant Tom Sorboro, Assistant Kurtis Townsend, Darius Taylor, Rotolu Adebiyi, Brandon Smith, Josh Asselin, Peter Vignier, Chris Young, Leland Anderson, LaVell Blanchard, Herb Gibson, Assistant Scott Trost, Assistant Lorenzo Neely.

Front Row: Trainer Steve Stricker, Mike Gotfredson, Gavin Groninger, Kevin Gaines, head coach Brian Ellerbe, Jamal Crawford, Leon Jones, Ramal Hunter, equip. mngr. Bob Bland.

Babylonische Texte : Inschriften von den Königen von Babylon von den Thontafeln des Britischen Museums, copirt und autographirt von J, N. Strassmaier.

[v.1] Hefte 1-4, Nabonidus.-[v.2] Hefte 5-6, Nabuchodonosor; Heft 6b, Evil-Merodach, Neriglissar, Laborosoarchod; Heft 7, Cyrus.-[v.3] Hefte 8-9, Cambyses; Hefte 10-12, Darius.

Die Schlacht bei Gaugamela. Eine Untersuchung zur Geschichte Alexanders d. Gr. und ihren Quellen; nebst einer Beilage ...

The "Beilage" has title: Die Tradition über die Friedens-verhandlungen zwischen Darius und Alexander.

Temple melodies : a collection of about two hundred popular tunes, adapted to nearly five hundred favorite hymns : selected with special reference to public, social and private worship /

Pages numbered [i]-vi, [7]-222, [1]-[2]

Le rationnel, études complémentaires à l'Essai sur la certitude logique,

Mode of access: Internet.

Essai sur les conditions et les limites de la certitude logique,

Mode of access: Internet.

The Babylonian Expedition of the University of Pennsylvania. Series A - Cuneiform Texts;

Historical and religious textts from the Temple Library of Nippur. 1914.

Das Alte Testament : übersetzt, eingeleitet und erläutert /

1. Allgemeine Einleitung zur Bibel. Ueberblick der Geschichte der Israeliten ... Richter Samuelis und Könige -- 2. Die Propheten -- 3. Die heilige Geschichte und das Gesetz. Der Pentateuch und Josua. -- 4. Die Kirchenchronik von Jerusalem. Chronik, Esra, Nehemia. -- 5. Die hebräische Poesie. Der Psalter, die Klaglieder und das Hohelied. -- 6. Religions- und Moralphilosophie der Hebräer. Hiob, Das Salomonische Spruchbuch, der Prediger, die Weisheit Jesu's, des Sohnes Sirachs, das Buch der Weisheit Salomo's ... Jona, Tobia, Susanna, die Pagen des Darius, Baruch, das Gebet Manasse's -- 7. Die politische und polemische Litteratur der Hebräer.

1997 University of Michigan Men's Basketball Team, NIT Champions

Back Row: Coach Steve Fisher, Tai Streets, Darius Taylor, Eric Szyndlar, Peter Vignier, Travis Conlin, Ron Oliver, Louis Bullock,

Front Row: Brandun Hughes, Jerod Ward, Maceo Baston, Robert Traylor, Maurice Taylor, Ryan DeKuiper, Nick Harastaris