991 resultados para Carn-Abastament-València


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Planos geométricos por términos municipales mandados formar por la ley de 27 de marzo de 1900

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This paper analyses the value of university collections of scientific instruments, their preservation, uses and improvement. It mostly relies on the data obtained by a research project on the scientific heritage of the University of Valencia.

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S’hi presenten les recerques realitzades a l’assentament fortificat ibèric del Cabeçó de Mariola (Alfafara, Alacant; Bocairent, València). S’hi han realitzat prospeccions superficials, geofísica i sondejos arqueològics assistits amb tecnologies geoespacials, a més de la inserció del lloc en el seu entorn territorial mitjançant els SIG. Els resultats mostren una àmplia seqüència d’ocupació, datada entre els segles IX i I aC, d’un important centre fortificat que controla un pas estratègic per a les comunicacions comarcals. Durant el període Ibèric tardà, en els segles II-I, presenta una intensa reestructuració de l’habitatge i les fortificacions que acabarà amb una violenta destrucció en el primer terç del s. I aC.

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Este artículo bibliográfico propone una panorámica de MonTI (Monografías de Traducción e Interpretación), una revista académica anual nacida en 2009 y publicada conjuntamente por las tres universidades públicas que ofrecen un grado en Traducción e Interpretación en la Comunidad Autónoma Valenciana.

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Pretende-se elaborar um modelo de apoio psicossocial dada a necessidade organizacional e da gestão dos recursos humanos afetos a esta resposta, demonstrando preocupação pela qualidade de vida dos indivíduos que lidam com vulnerabilidades indutoras de stress - visto que o presente estudo se desenvolve para a Sociedade Nacional da Cruz Vermelha: organização com cariz iminentemente social, estando na primeira linha da intervenção em incidentes geradores de stress, nas vítimas e nos profissionais que intervêm. Analisar-se-á o estado da arte dos modelos de intervenção psicossocial em incidentes e elaborar­se-á proposta de modelo teórico a aplicar na CVP - considerando que a estrutura trabalha com e para pessoas, e que todos podem enfrentar fatores de vulnerabilidade. Recorreu-se à metodologia da entrevista sarni-diretiva da amostra relevante para o estudo; efetuou-se pesquisa bibliográfica exploratória; elaborou-se revisão da literatura multidisciplinar e crítica, viabilizando a construção do modelo de apoio psicossocial que pode aplicar-se à intervenção da Cruz Vermelha Portuguesa. ABSTRACT: lntend to elaborate model of psychosocial support given the need for organizational and management of human resources dedicated to this response, showing concern for the quality of life of individuals who deal with vulnerabilities that induce stress - because the present study develops for the National Society of the Red Cross organization eminently social nature, being the first line of intervention in incidents generating stress on the victims and the professionals involved. Analyze will be state of the art models of psychosocial intervention in incidents and draw will be proposed a theoretical model applied in the CVP - considering that the structure works with and for people, and that all may experience vulnerability factors. Resorted to the methodology of semi-directive interview sample relevant to the study, was carried out bibliographical research; elaborated multidisciplinary review of the literature and criticism, making the construction of the model of psychosocial support that may apply to the intervention of Portuguese Red Cross.

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Castration is the standard therapy for advanced prostate cancer (PC). Although this treatment is initially effective, tumors invariably relapse as incurable, castration-resistant PC (CRPC). Adaptation of androgen-dependent PC cells to an androgen-depleted environment or selection of pre-existing,CRPC cells have been proposed as mechanisms of CRPC development. Stem cell (SC)-like PC cells have been implicated not only as tumor initiating/maintaining in PC but also as tumor-reinitiating cells in CRPC. Recently, castration-resistant cells expressing the NK3 homeobox 1 (Nkx3-1) (CARNs), the other luminal markers cytokeratin 18 (CK18) and androgen receptor (AR), and possessing SC properties, have been found in castrated mouse prostate and proposed as the cell-of-origin of CRPC. However, the human counterpart of CARNs has not been identified yet. Here, we demonstrate that in the human PC xenograft BM18, preexisting SC-like and neuroendocrine (NE) PC cells are selected by castration and survive as totally quiescent. SClike BM18 cells, displaying the SC markers aldehyde dehydrogenase 1A1 or NANOG, coexpress the luminal markers NKX3-1, CK18, and a low level of AR (ARlow) but not basal or NE markers. These CR luminal SC-like cells, but not NE cells, reinitiate BM18 tumor growth after androgen replacement. The ARlow seems to mediate directly both castration survival and tumor reinitiation. This study identifies for the first time in human PC SC-/CARN-like cells that may represent the cell-of-origin of tumor reinitiation as CRPC. This finding will be fundamental for refining the hierarchy among human PC cancer cells and may have important clinical implications.

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Berta Raposo Fernández e Ingrid García Wistädt (editoras)