p53 and little brother p53/47: linking IRES activities with protein functions

The tumor suppressor p53 represents a paradigm for gene regulation. Its rapid induction in response to DNA damage conditions has been attributed to both increased half-life of p53 protein and also increased translation of p53 mRNA. Recent advances in our understanding of the post-transcriptional regulation of p53 include the discovery of internal ribosome entry sites (IRESs) within the p53 mRNA. These IRES elements regulate the translation of the full length as well as the N-terminally truncated isoform, p53/47. The p53/47 isoform is generated by alternative initiation at an internal AUG codon present within the p53 ORF. The aim of this review is to summarize the role of translational control mechanisms in regulating p53 functions. We discuss here in detail how diverse cellular stress pathways trigger alterations in the cap-dependent and cap-independent translation of p53 mRNA and how changes in the relative expression levels of p53 isoforms result in more differentiated p53 activity.

Studio portrait of unidentified Levy brother (most likely Arthur or Hermann) in military uniform; Nogent-Sur-Seine, France.

Photographer's imprint lower left corner

Portrait of brother, mother and sister of Max Rieser seated outdoors; Franzensbad Portraits Family

Digital Image

Studio portrait of Lotte Schloss with her brother Helmut Schloss and their poodle Dolly; Wolfenbüttel, Germany.

Verso: correspondence

Lotte Schloss with her brother Helmut Schloss; Wolfenbüttel, Germany.

Verso: correspondence

Exterior view of the residence of brother-in-law Louis; Wolfenbuettel.

Digital Image

Margot Molling with her brother Adolf Molling; Laughlin, Nevada Portraits Family

Temperature: 117 F

Brother of Lola Gruenthal in Nice, France Portraits Men

Brother of Lola Gruenthal

Portrait of brother, mother and sister of Max Rieser seated outdoors; Franzensbad Portraits Family

Digital Image

Portrait of Ruth Augusta Beatrice Goldschmidt with her brother Henry H. Goldschmidt Gould Portraits Family

Henry, born July 15, 1914, died August 6, 1978; Ruth, born 1923?

Nachum Glatzer, Karl Mendel, Josef Soudek and Bernhard Glatzer (Nachum's younger brother) Portraits Groups Men

Signed by photographer lower right

Studio portraits of the brother of Max Rieser; Krakow Portraits Men

Digital Image

Shifting centres: Pedagogical relations in the Era of Big Data

This paper presents a cautious argument for re-thinking both the nature and the centrality of the one-to-one teacher/student relationship in contemporary pedagogy. A case is made that learning in and for our times requires us to broaden our understanding of pedagogical relations beyond the singularity of the teacher/student binary and to promote the connected teacher as better placed to lead learning for these times. The argument proceeds in three parts: first, a characterization of our times as defined increasingly by the digital knowledge explosion of Big Data; second, a re-thinking of the nature of pedagogical relationships in the context of Big Data; and third, an account of the ways in which leaders can support their teachers to become more effective in leading learning by being more closely connected to their professional colleagues.

Using Big Data to manage safety-related risk in the upstream oil and gas industry: A research agenda

Despite considerable effort and a broad range of new approaches to safety management over the years, the upstream oil & gas industry has been frustrated by the sector’s stubbornly high rate of injuries and fatalities. This short communication points out, however, that the industry may be in a position to make considerable progress by applying “Big Data” analytical tools to the large volumes of safety-related data that have been collected by these organizations. Toward making this case, we examine existing safety-related information management practices in the upstream oil & gas industry, and specifically note that data in this sector often tends to be highly customized, difficult to analyze using conventional quantitative tools, and frequently ignored. We then contend that the application of new Big Data kinds of analytical techniques could potentially reveal patterns and trends that have been hidden or unknown thus far, and argue that these tools could help the upstream oil & gas sector to improve its injury and fatality statistics. Finally, we offer a research agenda toward accelerating the rate at which Big Data and new analytical capabilities could play a material role in helping the industry to improve its health and safety performance.

A big idea transmitted pathetically

'A big idea transmitted pathetically' was an exhibition comprising a series of drawing works. These works employ a feminist engagement with the ‘big ideas’ of conceptual art, and enact a ‘redrawing’ of these texts to replay and reveal the complexities of gender politics, representation and language. These works were developed and presented for Bus Projects, Melbourne in 2012.