HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression

Identifying the immunologic and virologic consequences of discontinuing antiretroviral therapy in HIV-infected patients is of major importance in developing long-term treatment strategies for patients with HIV-1 infection. We designed a trial to characterize these parameters after interruption of highly active antiretroviral therapy (HAART) in patients who had maintained prolonged viral suppression on antiretroviral drugs. Eighteen patients with CD4+ T cell counts ≥ 350 cells/μl and viral load below the limits of detection for ≥1 year while on HAART were enrolled prospectively in a trial in which HAART was discontinued. Twelve of these patients had received prior IL-2 therapy and had low frequencies of resting, latently infected CD4 cells. Viral load relapse to >50 copies/ml occurred in all 18 patients independent of prior IL-2 treatment, beginning most commonly during weeks 2–3 after cessation of HAART. The mean relapse rate constant was 0.45 (0.20 log10 copies) day−1, which was very similar to the mean viral clearance rate constant after drug resumption of 0.35 (0.15 log10 copies) day−1 (P = 0.28). One patient experienced a relapse delay to week 7. All patients except one experienced a relapse burden to >5,000 RNA copies/ml. Ex vivo labeling with BrdUrd showed that CD4 and CD8 cell turnover increased after withdrawal of HAART and correlated with viral load whereas lymphocyte turnover decreased after reinitiation of drug treatment. Virologic relapse occurs rapidly in patients who discontinue suppressive drug therapy, even in patients with a markedly diminished pool of resting, latently infected CD4+ T cells.

Building a retrospective collection in pharmacy: a brief history of the literature with some considerations for U.S. health sciences library professionals

This paper argues that historical works in pharmacy are important tools for the clinician as well as the historian. With this as its operative premise, delineating the tripartite aspects of pharmacy as a business enterprise, a science, and a profession provides a conceptual framework for primary and secondary resource collecting. A brief history and guide to those materials most essential to a historical collection in pharmacy follows. Issues such as availability and cost are discussed and summarized in checklist form. In addition, a glossary of important terms is provided as well as a list of all the major U.S. dispensatories and their various editions. This paper is intended to serve as a resource for those interested in collecting historical materials in pharmacy and pharmaco-therapeutics as well as provide a history that gives context to these classics in the field. This should provide a rationale for selective retrospective collection development in pharmacy.

Differences in exposure to occupational health risks in Spanish and foreign-born workers in Spain (Itsal Project)

Migrant workers usually show higher rates of work-related health problems than natives. However, little information is available about their exposure to occupational risks. We describe self-reported working exposure in Spanish and foreign-born workers. A cross-sectional survey was conducted as part of the ITSAL Project. Data on sociodemographic and self-reported occupational exposure in 1,841 foreign-born and 509 Spanish workers were collected through face-to-face interviews. Prevalence and adjusted odds ratios-aOR- (by age, education, type of contract) were calculated. Foreign-born men in non-services sectors and those in manual occupations perceived exposure to occupational risks with lower prevalence than Spanish workers. Foreign-born women reported higher prevalence of exposure than Spanish female workers. By occupation, foreign-born female workers were more likely than Spanish workers to report working many hours/day (aOR2.68; 95 % CI 1.06–6.78) and exposure to extreme temperatures (aOR2.19; 95 % CI 1.10–4.38). Some groups of migrant workers may need increased protection regarding some occupational exposures.

First steps toward harmonized human biomonitoring in Europe : demonstration project to perform human biomonitoring on a European scale

'Reproduced with permission from Environmental Health Perspectives'

In the shadow of history. Romanian-Moldovan relations. OSW Studies 53, September 2015

Romania and Moldova have developed very strong ties, resulting mainly from many years of common history (including joint statehood), language and cultural heritage. On the one hand, this closeness fosters bilateral relations, but on the other hand it places a serious burden upon them. This is because Moldovan statehood and identity has in some way been built in opposition to Romanian statehood and identity. Part of Moldovan society (especially the Russian-speaking minority) fears closer cooperation with Bucharest, seeing it as threatening a loss of independence and the declaration of unification with its western neighbour. Historic sentiment is also reflected in Bucharest’s policy towards Moldova. Officially, relations with Chisinau are considered as exceptional, and representatives of the Romanian political class are full of declarations of assistance and support for their eastern neighbour, appealing to the national, cultural and linguistic community. In practice, however, Romanian policy towards Moldova (and hence also the two countries’ bilateral relations) is most often shaped not by sentiment but by political pragmatism, resulting among others from a desire to win the support of the Romanian electorate.

First in flight : a short history of the enlisted aircrew member in the Air National Guard /

"A special thanks to CMSgt Dan Roberson (NGB), MSgt Gary Clark (189AW) and TSgt Brian Irvin (109AW) for their research and contributions to this abbreviated Air National Guard Enlisted Aircrew history"--P. [4] of cover.

The changing faces of tradition : a report on the folk and traditional arts in the United States /

Shipping list no.: 97-0040-P.

Towards a new beginning in cooperative cataloging : the history, progress, and future of the Cooperative Cataloging Council /

Includes bibliographical references (p. 76).