811 resultados para Architecture and Complexity


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Issues for 1889-1891 not numbered but constitute v. 1-3.

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Title from caption.

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Mode of access: Internet.

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Emil Lorch & Associates, architect. Built in 1928. Architecture Building; later called Architecture & Design; renamed Lorch Hall ca. 1980. The Doric columns were once part of the oldest stone building in Detroit, the Bank of Michigan, built 1836. The Corinthian column was from the Home Office Bldg. of the Mutural Benefit Life Insurance Co. of Newark, N.J.

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Emil Lorch & Associates, architect. Built in 1928. Architecture Building; later called Architecture & Design; renamed Lorch Hall ca. 1980

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"An edited version of the report Professional liability and responsibility, prepared in collaboration with the Subcommittee on Professional Liability and Responsibility of American Institute of Architects-Engineers Joint Council Liaison Committee."

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Cannabis is one of the most commonly used illicit drugs, and its effects have traditionally been seen as less harmful than outcomes associated with the highly prevalent use of alcohol and other illicit substances (e.g., cocaine and amphetamines), and injecting drugs. Consequently, less attention has been focused on developing and evaluating interventions in this area. However, current research supports the idea that cannabis does pose a number of acute and chronic health risks to the individual and to society. The authors review findings concerning the physiological and neurological effects of cannabis, prevalence of use, and studies concerning its possible role as a "gateway" drug. Diagnostic criteria for cannabis dependence and abuse are discussed, with a focus on whether a cannabis withdrawal syndrome exists and if so how it can be diagnosed. There is strong support for a link between cannabis and the development and exacerbation of psychosis and other mental health conditions (e.g., anxiety, depression). Further research is needed to determine the underlying neurochemical processes and their possible contribution to etiology, as well as the social factors that contribute to the increasing use of cannabis by young people. In addition there is a need for systematic evaluation using randomized controlled trials to determine effective prevention and treatment strategies. A number of public health programs that address cannabis use are reviewed along with available evidence for their effectiveness.

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Mammalian promoters can be separated into two classes, conserved TATA box-enriched promoters, which initiate at a welldefined site, and more plastic, broad and evolvable CpG-rich promoters. We have sequenced tags corresponding to several hundred thousand transcription start sites (TSSs) in the mouse and human genomes, allowing precise analysis of the sequence architecture and evolution of distinct promoter classes. Different tissues and families of genes differentially use distinct types of promoters. Our tagging methods allow quantitative analysis of promoter usage in different tissues and show that differentially regulated alternative TSSs are a common feature in protein-coding genes and commonly generate alternative N termini. Among the TSSs, we identified new start sites associated with the majority of exons and with 3' UTRs. These data permit genome-scale identification of tissue-specific promoters and analysis of the cis-acting elements associated with them.