Sala de recursos para deficientes visuais: contribuições para o processo de inclusão escolar

This work is situated in the universe of resource rooms with a focus on the teachinglearning disabled students with low vision and visual in two cities of São Paulo. The paper discusses theoretically the historical emergence of these rooms, the deployment in the State of São Paulo and its importance within the context of school inclusion of students with visual impairments. Its purpose is to conduct a general survey of the operating conditions of the rooms from the perspective of the teacher of students. The results verified the contribution of this service as a complementary tool of the ordinary classroom, the use of specific instructional materials and overall educational performance of students. The results indicate that this type of specialized care while receiving criticism, does not promote segregation, but what about the educational needs of these students, who despite the lack of vision, school performance is equal to or better than the other students in the classroom common, it all depends on family support, and dedication to studies by the student. Research has shown students satisfied with the services provided in the resource room, as well as integration and good relationships between teachers and students. We could also highlight the importance of specific training and mastery of knowledge by the teacher to work with the visually impaired person. At the end the results were sent to the schools of this research object of study so that it can contribute to effective work in the educational process for visually impaired students in resource rooms

Técnicas de análise de dados distribuídos em áreas

Pós-graduação em Biometria - IBB

Processo de medição de desempenho em micro e pequenas empresas de um arranjo produtivo local

The local productive arrangements (LPA) are organizational mechanisms that enable the continuous performance of small businesses in production processes and business management models. To promote continuous improvement is essential that companies make decisions based on data that reflects business’ performance (performance measurement) and promote the cluster performance. This way, the aim of this article is to describe the performance measurement process that will support the corporate management of Micro and Small enterprises (SME) of a Local Productive Arrangement in Maringá, State of Paraná, Brazil. To develop this paper, the bibliographic search and action research methods were used. The field research was developed from the cooperation project (PROJVEST) conducted at the LPA, which goal is to deploy improvement actions in project’s participating companies. Metrics and performance indicators constructed from the diagnosis in the areas of Production, Quality and Ergonomics in companies will be presented. Among the main results, can be pointed out that the performance management of LPA is promoting the introduction of corporate management practices in SMEs, stimulating business cooperation, the continuous innovation in manufacturing processes and product quality and business processes.

Estudo da relação de ordem-desordem estrutural em nanopartículas de TiO2

Pós-graduação em Química - IQ

Dinâmica de corpos lúteos em protocolos com redução da dose de FSH na superovulação em ovelhas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Gestão, território e desenvolvimento: dificuldades e perspectivas do município de Tabatinga - SP

Pós-graduação em Geografia - IGCE

Segue 3: the youngest globular cluster in the outer halo

Deep Galileo (Telescopio Nazionale Galileo) B, V and I images of Segue 3, reaching V ∼ 25, reveal that it is the youngest globular cluster known so far in the Galaxy. A young age of 3.2 Gyr is found, differently from a previous estimate of 12 Gyr. It also appears to be moderately metal rich with [Fe/H] ∼ −0.8, rather than [Fe/H] ∼ −1.7, as previously suggested by Fadely et al. A main difference in the age derivation relative to Fadely et al. comes from the consideration of subgiant branch stars in the isochrone fitting. A deduced distance of d⊙ = 29.1 kpc is compatible with the outer halo location of other low luminosity globular clusters.

Ruolo del test da sforzo cardiopolmonare nei pazienti affetti da cardiomiopatia ipertrofica in età pediatrica

Background Decreased exercise capacity, and reduction in peak oxygen uptake are present in most patients affected by hypertrophic cardiomyopathy (HCM) . In addition an abnormal blood pressure response during a maximal exercise test was seen to be associated with high risk for sudden cardiac death in adult patients affected by HCM. Therefore exercise test (CPET) has become an important part of the evaluation of the HCM patients, but data on its role in patients with HCM in the pediatric age are quite limited. Methods and results Between 2004 and 2010, using CPET and echocardiography, we studied 68 children (mean age 13.9 ± 2 years) with HCM. The exercise test was completed by all the patients without adverse complications. The mean value of achieved VO2 max was 31.4 ± 8.3 mL/Kg/min which corresponded to 77.5 ± 16.9 % of predicted range. 51 patients (75%) reached a subnormal value of VO2max. On univariate analysis the achieved VO2 as percentage of predicted and the peak exercise systolic blood pressure (BP) Z score were inversely associated with max left ventricle (LV) wall thickness, with E/Ea ratio, and directly related with Ea and Sa wave velocities No association was found with the LV outflow tract gradient. During a mean follow up of 2.16 ± 1.7 years 9 patients reached the defined clinical end point of death, transplantation, implanted cardioverter defibrillator (ICD) shock, ICD implantation for secondary prevention or myectomy. Patients with peak VO2 < 52% or with peak systolic BP Z score < -5.8 had lower event free survival at follow up. Conclusions Exercise capacity is decreased in patients with HCM in pediatric age and global ventricular function seems being the most important determinant of exercise capacity in these patients. CPET seems to play an important role in prognostic stratification of children affected by HCM.

Growth hormone (GH) deficiency type II: a novel GH-1 gene mutation (GH-R178H) affecting secretion and action

Context and Objective: Main features of the autosomal dominant form of GH deficiency (IGHD II) include markedly reduced secretion of GH combined with low concentrations of IGF-I leading to short stature. Design, Setting, and Patients: A female patient presented with short stature (height -6.0 sd score) and a delayed bone age of 2 yr at the chronological age of 5 yr. Later, at the age of 9 yr, GHD was confirmed by standard GH provocation test, which revealed subnormal concentrations of GH and a very low IGF-I. Genetic analysis of the GH-1 gene revealed the presence of a heterozygous R178H mutation. Interventions and Results: AtT-20 cells coexpressing both wt-GH and GH-R178H showed a reduced GH secretion after forskolin stimulation compared with the cells expressing only wt-GH, supporting the diagnosis of IGHD II. Because reduced GH concentrations found in the circulation of our untreated patient could not totally explain her severe short stature, functional characterization of the GH-R178H performed by studies of GH receptor binding and activation of the Janus kinase-2/signal transducer and activator of transcription-5 pathway revealed a reduced binding affinity of GH-R178H for GH receptor and signaling compared with the wt-GH. Conclusion: This is the first report of a patient suffering from short stature caused by a GH-1 gene alteration affecting not only GH secretion (IGHD II) but also GH binding and signaling, highlighting the necessity of functional analysis of any GH variant, even in the alleged situation of IGHD II.

Biological determinants of responsiveness to growth hormone: pharmacogenomics and personalized medicine

It is becoming most clear that many genes are involved in controlling the regulation of growth. Ultimately however, at the level of growth hormone (GH), the relevant question may be not whether a patient is GH-deficient, but whether he is GH-responsive. As these disturbances can be divided into two gross categories, namely alterations causing subnormal GH secretion and/or those presenting with subnormal GH sensitivity/responsiveness, the main aim of this review is to focus on genes involved in growth regulation leading to short stature caused by an alteration of GH insensitivity/GH responsiveness; in other words, clinical circumstances where individually adapted GH replacement therapy may help to increase height velocity and eventually final height.

Backward Extensions of Recursively Generated Weighted Shifts and Quadratic Hyponormality

Given the weight sequence for a subnormal recursively generated weighted shift on Hilbert space, one approach to the study of classes of operators weaker than subnormal has been to form a backward extension of the shift by prefixing weights to the sequence. We characterize positive quadratic hyponormality and revisit quadratic hyponormality of certain such backward extensions of arbitrary length, generalizing earlier results, and also show that a function apparently introduced as a matter of convenience for quadratic hyponormality actually captures considerable information about positive quadratic hyponormality.

Tridiagonal Reproducing Kernels and Subnormality

We consider analytic reproducing kernel Hilbert spaces H with orthonormal bases of the form {(a(n) + b(n)z)z(n) : n >= 0}. If b(n) = 0 for all n, then H is a diagonal space and multiplication by z, M-z, is a weighted shift. Our focus is on providing extensive classes of examples for which M-z is a bounded subnormal operator on a tridiagonal space H where b(n) not equal 0. The Aronszajn sum of H and (1 - z)H where H is either the Hardy space or the Bergman space on the disk are two such examples.

k-Hyponormality and n-Contractivity for Agler-Type Shifts

We consider k-hyponormality and n-contractivity (k, n = 1, 2, ...) as "weak subnormalities" for a Hilbert space operator. It is known that k-hyponormality implies 2k-contractivity; we produce some classes of weighted shifts including a parameter for which membership in a certain n-contractive class is equivalent to k-hyponormality. We consider as well some extensions of these results to operators arising as restrictions of these shifts, or from linear combinations of the Berger measures associated with the shifts.

GH mutant (R77C) in a pedigree presenting with the delay of growth and pubertal development: structural analysis of the mutant and evaluation of the biological activity

A heterozygous missense mutation in the GH-1 gene converting codon 77 from arginine (R) to cysteine (C), which was previously reported to have some GH antagonistic effect, was identified in a Syrian family. The index patient, a boy, was referred for assessment of his short stature (-2.5 SDS) at the age of 6 years. His mother and grandfather were also carrying the same mutation, but did not differ in adult height from the other unaffected family members. Hormonal examination in all affected subjects revealed increased basal GH, low IGF-I concentrations, and subnormal IGF-I response in generation test leading to the diagnosis of partial GH insensitivity. However, GH receptor gene (GHR) sequencing demonstrated no abnormalities. As other family members carrying the GH-R77C form showed similar alterations at the hormonal level, but presented with normal final height, no GH therapy was given to the boy, but he was followed through his pubertal development which was delayed. At the age of 20 years he reached his final height, which was normal within his parental target height. Functional characterization of the GH-R77C, assessed through activation of Jak2/Stat5 pathway, revealed no differences in the bioactivity between wild-type-GH (wt-GH) and GH-R77C. Detailed structural analysis indicated that the structure of GH-R77C, in terms of disulfide bond formation, is almost identical to that of the wt-GH despite the introduced mutation (Cys77). Previous studies from our group demonstrated a reduced capability of GH-R77C to induce GHR/GH-binding protein (GHBP) gene transcription rate when compared with wt-GH. Therefore, reduced GHR/GHBP expression might well be the possible cause for the partial GH insensitivity found in our patients. In addition, this group of patients deserve further attention because they could represent a distinct clinical entity underlining that an altered GH peptide may also have a direct impact on GHR/GHBP gene expression causing partial GH insensitivity. This might be responsible for the delay of growth and pubertal development. Finally, we clearly demonstrate that GH-R77C is not invariably associated with short stature, but that great care needs to be taken in ascribing growth failure to various heterozygous mutations affecting the GH-IGF axis and that careful functional studies are mandatory.

Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy

OBJECTIVES: To assess the prevalence of abnormal testosterone and gonadotropin values in HIV-infected men before and after 2 years of combination antiretroviral therapy (cART). DESIGN: Multicentre cohort of HIV-infected adults. METHODS: We identified 139 Caucasian antiretroviral-naive male patients who started zidovudine/ lamivudine-based cART that was virologically successful over a 2 year period. Ninety-seven were randomly chosen and plasma hormone determinations of free testosterone (fT) and luteinizing hormone (LH) at baseline and after 2 years of cART were evaluated. RESULTS: At baseline 68 patients (70%) had subnormal fT levels. In these, LH levels were low in 44%, normal in 47% and high in 9%. There was a trend for an association between lower CD4+ T-cell counts and hypogonadism. Most participants had normal FSH levels. No significant changes of fT, LH and FSH levels were observed after 2 years of cART. CONCLUSIONS: Low fT levels, mainly with normal or low LH levels and thus indicating secondary hypogonadism, are found in the majority of HIV-infected men and do not resolve during 2 years of successful cART.