1000 resultados para A9-13D
Resumo:
1913/05 (A9,N33)-1914/02 (A9,N36).
Resumo:
1884 (A9,VOL9,PART1)- (A9,VOL9,PART2).
Resumo:
1887 (A9,N10).
Resumo:
BACKGROUND: Biomarkers are a promising tool for the management of patients with atherosclerosis, but their variation is largely unknown. We assessed within-subject and between-subject biological variation of biomarkers in peripheral artery disease (PAD) patients and healthy controls, and defined which biomarkers have a favorable variation profile for future studies. METHODS: Prospective, parallel-group cohort study, including 62 patients with stable PAD (79% men, 65±7years) and 18 healthy control subjects (44% men, 57±7years). Blood samples were taken at baseline, and after 3-, 6-, and 12-months. We calculated within-subject (CVI) and between-subject (CVG) coefficients of variation and intra-class correlation coefficient (ICC). RESULTS: Mean levels of D-dimer, hs-CRP, IL-6, IL-8, MMP-9, MMP-3, S100A8/A9, PAI-1, sICAM-1, and sP-selectin levels were higher in PAD patients than in healthy controls (P≤.05 for all). CVI and CVG of the different biomarkers varied considerably in both groups. An ICC≥0.5 (indicating moderate-to-good reliability) was found for hs-CRP, D-Dimer, E-selectin, IL-10, MCP-1, MMP-3, oxLDL, sICAM-1 and sP-selectin in both groups, for sVCAM in healthy controls and for MMP-9, PAI-1 and sCD40L in PAD patients. CONCLUSIONS: Single biomarker measurements are of limited utility due to large within-subject variation, both in PAD patients and healthy subjects. D-dimer, hs-CRP, MMP-9, MMP-3, PAI-1, sP-selectin and sICAM-1 are biomarkers with both higher mean levels in PAD patients and a favorable variation profile making them most suitable for future studies.
Resumo:
1884 (A9,N11)-1886 (A10,N11).
Resumo:
1850 (A9,T9,SER2).
Resumo:
1877 (A9,Planches).
Resumo:
1877 (A9,T1).
Resumo:
1877 (A9,T2).
Resumo:
1895 (A9).
Resumo:
1866 (A9).
Resumo:
1896 (A9).
Resumo:
1867 (A9).
Resumo:
1906 (A9).
Resumo:
1896/12/17 (A9,N428)-1896/12/23.
