Circulating oxidized LDL is associated with the occurrence of echolucent plaques in the carotid artery in 61-year-old men.

OBJECTIVE The aim of this study was to elucidate the relationship between the echogenicity of carotid artery plaques and the following risk factors: circulating oxLDL, hsCRP, the metabolic syndrome (MetS), and several of the traditional cardiovascular (CV) risk factors. MATERIAL AND METHODS A cross-sectional population-based study of 513 sixty-one-year-old men. The levels of circulating oxLDL were determined in plasma samples by sandwich ELISA utilizing a specific murine monoclonal antibody (mAb-4E6). High-sensitivity CRP was measured in plasma by ELISA. Plaque occurrence, size and echogenicity were evaluated from B-mode ultrasound registrations in the carotid arteries. Plaque echogenicity was assessed based on a four-graded classification scale. RESULTS A higher frequency of echolucent carotid plaques was observed with increasing levels of oxLDL and systolic blood pressure (p = 0.008 and p = 0.041, respectively). Subjects with the MetS had a significantly higher frequency of echogenic plaques than subjects without the MetS (p = 0.009). In a multiple logistic regression analysis, oxLDL turned out to be independently associated with echolucent carotid plaques. CONCLUSIONS The occurrence of echolucent carotid plaques was associated with oxLDL and systolic blood pressure, and oxLDL was associated with echolucent carotid plaques independently of systolic blood pressure.

Circulating oxidized low-density lipoprotein is associated with echolucent plaques in the femoral artery independently of hsCRP in 61-year-old men.

OBJECTIVES The aim of the study was to test the hypothesis that circulating markers of inflammation (high-sensitive C-reactive protein, hsCRP) and oxidative modification of lipids (oxidized low-density lipoprotein, oxLDL) were associated with the occurrence of echolucent rather than echogenic femoral artery plaques in a cross-sectional population based cohort of 513, 61-year-old men. BACKGROUND The relationships between circulating oxLDL, hsCRP and the occurrence of echolucent plaques in the femoral artery have not previously been investigated. METHODS The levels of circulating oxLDL and hsCRP were determined in plasma by ELISA. Plaque occurrence, size and echogenicity were measured by B-mode ultrasound in the right femoral artery. Assessment of plaque echogenicity was based on the classification (grades 1-4) proposed by Gray-Weale et al. RESULTS A higher frequency of echolucent femoral plaques was observed in subjects with the metabolic syndrome and current smokers (p=0.01 and p<0.001, respectively) as well as with increasing levels of oxLDL and hsCRP (p=0.002 and p=0.005, respectively). In a multiple logistic regression analysis oxLDL and current smokers turned out to be independent associated with the presence of echolucent femoral artery plaques. CONCLUSIONS The results of the present study support our hypothesis that circulating oxLDL is a marker of an unstable echolucent plaque phenotype in the femoral artery in man.

Ms. germ. oct. 61 - Auszug der Kinder Israels, Teil I und II, mit Auslegung der zehn Gebote

Vorbesitzer: Hechin Dilich; Johann Hartmann Beyer; Barfüßerbibliothek Frankfurt am Main

Ms. germ. fol. 61 - Königlich preußische Verordnungen über die Exekution und über den Subhastationsprozeß

Alte Signatur: 4400;

Ms. Praed. 61 - Juristische Sammelhandschrift

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 61 - Ratschlag für die Erbschaftsangelegenheiten in der Familie Schopenhauer

u.a.: Eigenschaften der Kaufleute; Verhältnis zur Mutter Johanna Schopenhauer; Briefwechsel mit der Schwester Adele Schopenhauer; Reise Schopenhauers nach Frankreich; Schulden; H. Croulen; Heinrich Floris Schopenhauer;

Ms.Ff.F.Stoltze 3. 61 - Brief von Rudolf Fendt an Friedrich Stoltze

Persönliche Nachrichten, Ernst Emmerling, Leopold Sonnemann

Fragm. lat. VII 90 - De bello Iudaico (L. VII c. 61 - 66)

Trägerband: Q 16/109; Vorbesitzer: Philippus Jacobus Otto

Inc. hebr. 61 - Perush seder ha-tefilot

Vorbesitzer: Abraham Merzbacher (?)

Fragm. lat. VII 61 - Kanonistischer Text

Trägerband: Inc. qu. 873; Vorbesitzer: Dominikanerkloster Frankfurt am Main

Ms. lat. oct. 61 - Directorium Moguntinum ad usum ecclesiae S. Bartholomaei Francfordensis

Die tatsächliche Blattzahl weicht von den Angaben des Kataloges ab.

Fragm. lat. I 18 - Micrologus (c. 23, 46 - 49, 51 - 61)

Trägerbände: Ms. Barth. 13; Ms. Barth. 18; Ms. Barth. 29; Ms. Barth. 41; Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Sonate pour le pianoforte et flûte oeuv. 61

par F. Schneider