Paracoccidioidomicose: estudo radiológico e pulmonar de 58 casos

Spirometric and haemogasimetric tests were performed in 52 patients with unifocal and multifocal progressive Paracoccidioidomycosis pulmonary diseases, in 5 patients with juvenile and 1 female internal genital forms. The age ranged from 20 to 74 years old and the duration of disease from 3 to 25 years. Dyspnea, cough, tegumentary and lymphatic manifestations were the most predominant signs observed. Fourteen of them was developed Cor pulmonale. Impaired renal function was recorded in 19 patients, cardiac symptoms were described in 7 and hyporeactor adrenal activity was showed in 13 patients. Radiological studies demonstrated mild in 16, moderate in 24 and severe pulmonary lesions types in 18 patients. The pulmonary function revealed: normal spyrographic findings in 17, pure obstructive type in 32 and mixed form in 9 of them. Hyperventilation was described in 54 individuals and all of them showed an increasing of the alveolo-arterial difference. PaO2 less than 80 mm/Hg observed in 36 of them. Statistical analysis demonstrated significative association between clinical evolution and radiological interpretation. Similar data were obtained in radiology evaluations, clinical evolutive studies and pulmonary functions described in these patients. The granulomatous reaction due to Paracoccidioidomycosis, in heavy smokers patients, gave origin to the alterations in small airways predisposing the interalveolar dissemination an impaired alveolo-arterial diffusion.

Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine

Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of nucleosides and deoxynucleosides, generating ribose 1-phosphate and the purine base, which is an important step of purine catabolism pathway. The lack of such an activity in humans, owing to a genetic disorder, causes T-cell impairment, and drugs that inhibit this enzyme may have the potential of being utilized as modulators of the immunological system to treat leukemia, autoimmune diseases, and rejection in organ transplantation. Here, we describe kinetics and crystal structure of human PNP in complex with 7-methyl-6-thio-guanosine, a synthetic substrate, which is largely used in activity assays. Analysis of the structure identifies different protein conformational changes upon ligand binding, and comparison of kinetic and structural data permits an understanding of the effects of atomic substitution on key positions of the synthetic substrate and their consequences to enzyme binding and catalysis. Such knowledge may be helpful in designing new PNP inhibitors. © 2005 Elsevier Inc. All rights reserved.

Resolución 442(XIX): Medidas para promover el cumplimiento de los objetivos del Decenio Internacional del Agua Potable y del Saneamiento Ambiental en América Latina = Resolution 442(XIX): Measures to promote the achievement of the objectives of the International Drinking Water Supply and Sanitation Decade in Latin America = Résolution 442(XIX): Mesures destinées à faciliter la réalisation des objectifs de la Décennie internationale de l'eau potable et de l'assainissement

Publicado separadamete en cada idioma

Resolución 260(AC.58): Instituto Latinoamericano de Planificación Económica y Social = Resolution 260(AC.58): Latin American Institute for Economic and Social Planning = Résolution 260(AC.58): Institut Latino-américain de Planification Economique et Sociale

Incluye Bibliografía

Resolución 261(AC.58): Participación popular y desarrollo comunal = Resolution 261(AC.58): Public participation and community development = Résolution 261(AC.58): Participation publique et développement communautaire

Incluye Bibliografía

Resolución 262(AC.58): Actividades de la CEPAL en materia de comercio y desarrollo = Resolution 262(AC.58): ECLA's activities in the field of trade and development = Résolution 262(AC.58): Activités de la CEPAL concernant le commerce et le développement

Incluye Bibliografía

Estudo palinológico das formações Serra Alta, Teresina e Rio do Rasto nos furos de sondagem SP-23-PR e SP-58-PR, centro-norte do Paraná (Permiano, Bacia do Paraná)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Notas de la CEPAL Nº 58

Edición dedicada al Trigésimosegundo período de sesiones de la CEPAL (Santo Domingo, República Dominicana, 9-13 de junio de 2008)La transformación productiva 20 años después. Viejos problemas, nuevas oportunidades. CEPAL presenta informe sobre financiamiento para el desarrollo. Opinión del Secretario Ejecutivo de la CEPAL, José Luis Machinea. Las nuevas oportunidades para América Latina y el Caribe. Precisiones. Alianzas público-privadas para el desarrollo exportador. Indicadores. Opinión del Secretario Ejecutivo de la CEPAL, José Luis Machinea. América Latina y el Caribe en la nueva coyuntura internacional. Publicaciones recientes. Calendario de eventos

ECLAC Notes Nº 58

Special edition dedicated to the Thirty-second session of ECLAC (Santo Domingo, Dominican Republic,9-13 June 2008): Structural Change and Productivity Growth, 20 Years Later. Old problems, new opportunities ECLAC Presents Report on Financing for Development Op-ed by ECLAC's Executive Secretary, José Luis Machinea. New Opportunities for Latin America and the Caribbean Highlights. Public-private Alliances for Export DevelopmentIndicatorsOp-ed by ECLAC's Executive Secretary, José Luis Machinea. Latin America and theCaribbean in the New International Context Recent titles Calendar of events