975 resultados para 130-806
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Esta dissertação pretende analisar criticamente o julgado da ADPF 130, a luz do pensamento político de Hannah Arendt, em razão de conduzir o debate do significado da imprensa idônea para a promoção da liberdade de expressão quando torna efetivo o princípio da publicidade na esfera pública. O pensamento da autora contribui para avaliar criticamente a racionalidade do Poder judiciário brasileiro na decisão da ADPF 130 pelo fato deste conceber de modo questionável a imprensa ter o papel democrático de ser formadora de opinião pública e de compreender que qualquer lei para regulamentar a atividade midiática implica automaticamente em cair no risco da censura prévia. No capítulo I, o trabalho sumariza as argumentações propostas na ADPF para indicar que a maioria dos votos dos ministros se situa a partir das concepções gerais do liberalismo e as suas consequências para atuação da imprensa na democracia brasileira. Em seguida, na primeira parte do capítulo II serão apresentadas as principais características do pensamento político de Arendt contempladas nas obras A condição humana e Origens do totalitarismo, em uma perspectiva de situá-las na tradição política do pensamento político ocidental, expondo, de forma geral, os contornos de seu sistema político, como: distinção entre domínio público e domínio privado, vita activa e doxa e função da lei. Assim, passa-se a analisar, em momento posterior no capítulo II as manifestações do pensamento arendtiano em torno da liberdade de expressão e a repercussão do seu significado na imprensa idônea. O capítulo III posiciona o pensamento arendtiano na tradição política do mundo ocidental. Nele, Arendt aponta quando a liberdade política que se manifesta entre o eu-posso e eu-quero se dissocia, o qual ocasiona obstáculos para a aparição da doxa no agir em concerto entre os homens. Assim, equivocadamente a política passa a ser vista apenas como um velho truísmo de assegurar a liberdade. Compreendemos que, neste contexto, a imprensa é concebida pela maioria dos votos dos ministros com o papel de ser formadora de opinião pública pelo fato de considerarem implicitamente que vivemos numa democracia onde os homens não participam efetivamente na vida pública.
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The present study aims to present and analyze the ruling of the Brazilian Supreme Court in ADPF 130 (Concentrated constitutional review action, Fundamental Precept Infringement, Argüição de Descumprimento de Preceito Fundamental), proposed by Partido Democrático Trabalhista (PDT), which contests the compatibility of statute 5.250/67 with the Federal Constitution of 1988. This work considers that the judicial ruling is different than the approach taken by the Legislative and Executive powers, arguing that there is, in the Judiciary, a peculiar way for ruling, surrounded by mysteries, rites, secrets, pomp and circunstances unintelligible to layman. To reach the proposed goal, Justice Carlos Brito´s report and opinion on ADPF 130 are analyzed. The choice of giving special attention to this opinion, which favors the declaration of unconstitutionality of the 5.250/67 statute, is justified in that it represents agreement with the allegation of disrespect to the constitutional text, as suggested by the Partido Democrático Trabalhista. The arguments put forth by the presiding Justice on his ruling will also be the object of consideration, as well as some possible consequences of the ruling.
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The South Carolina Teacher Association History collection consists of a publication written by David Duncan Wallace titled History of the South Carolina Teachers' Association in 1924. The publication covers the history of the South Carolina Teacher Association from its founding in 1850 to 1924.
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Introduction 1.1 Occurrence of polycyclic aromatic hydrocarbons (PAH) in the environment Worldwide industrial and agricultural developments have released a large number of natural and synthetic hazardous compounds into the environment due to careless waste disposal, illegal waste dumping and accidental spills. As a result, there are numerous sites in the world that require cleanup of soils and groundwater. Polycyclic aromatic hydrocarbons (PAHs) are one of the major groups of these contaminants (Da Silva et al., 2003). PAHs constitute a diverse class of organic compounds consisting of two or more aromatic rings with various structural configurations (Prabhu and Phale, 2003). Being a derivative of benzene, PAHs are thermodynamically stable. In addition, these chemicals tend to adhere to particle surfaces, such as soils, because of their low water solubility and strong hydrophobicity, and this results in greater persistence under natural conditions. This persistence coupled with their potential carcinogenicity makes PAHs problematic environmental contaminants (Cerniglia, 1992; Sutherland, 1992). PAHs are widely found in high concentrations at many industrial sites, particularly those associated with petroleum, gas production and wood preserving industries (Wilson and Jones, 1993). 1.2 Remediation technologies Conventional techniques used for the remediation of soil polluted with organic contaminants include excavation of the contaminated soil and disposal to a landfill or capping - containment - of the contaminated areas of a site. These methods have some drawbacks. The first method simply moves the contamination elsewhere and may create significant risks in the excavation, handling and transport of hazardous material. Additionally, it is very difficult and increasingly expensive to find new landfill sites for the final disposal of the material. The cap and containment method is only an interim solution since the contamination remains on site, requiring monitoring and maintenance of the isolation barriers long into the future, with all the associated costs and potential liability. A better approach than these traditional methods is to completely destroy the pollutants, if possible, or transform them into harmless substances. Some technologies that have been used are high-temperature incineration and various types of chemical decomposition (for example, base-catalyzed dechlorination, UV oxidation). However, these methods have significant disadvantages, principally their technological complexity, high cost , and the lack of public acceptance. Bioremediation, on the contrast, is a promising option for the complete removal and destruction of contaminants. 1.3 Bioremediation of PAH contaminated soil & groundwater Bioremediation is the use of living organisms, primarily microorganisms, to degrade or detoxify hazardous wastes into harmless substances such as carbon dioxide, water and cell biomass Most PAHs are biodegradable unter natural conditions (Da Silva et al., 2003; Meysami and Baheri, 2003) and bioremediation for cleanup of PAH wastes has been extensively studied at both laboratory and commercial levels- It has been implemented at a number of contaminated sites, including the cleanup of the Exxon Valdez oil spill in Prince William Sound, Alaska in 1989, the Mega Borg spill off the Texas coast in 1990 and the Burgan Oil Field, Kuwait in 1994 (Purwaningsih, 2002). Different strategies for PAH bioremediation, such as in situ , ex situ or on site bioremediation were developed in recent years. In situ bioremediation is a technique that is applied to soil and groundwater at the site without removing the contaminated soil or groundwater, based on the provision of optimum conditions for microbiological contaminant breakdown.. Ex situ bioremediation of PAHs, on the other hand, is a technique applied to soil and groundwater which has been removed from the site via excavation (soil) or pumping (water). Hazardous contaminants are converted in controlled bioreactors into harmless compounds in an efficient manner. 1.4 Bioavailability of PAH in the subsurface Frequently, PAH contamination in the environment is occurs as contaminants that are sorbed onto soilparticles rather than in phase (NAPL, non aqueous phase liquids). It is known that the biodegradation rate of most PAHs sorbed onto soil is far lower than rates measured in solution cultures of microorganisms with pure solid pollutants (Alexander and Scow, 1989; Hamaker, 1972). It is generally believed that only that fraction of PAHs dissolved in the solution can be metabolized by microorganisms in soil. The amount of contaminant that can be readily taken up and degraded by microorganisms is defined as bioavailability (Bosma et al., 1997; Maier, 2000). Two phenomena have been suggested to cause the low bioavailability of PAHs in soil (Danielsson, 2000). The first one is strong adsorption of the contaminants to the soil constituents which then leads to very slow release rates of contaminants to the aqueous phase. Sorption is often well correlated with soil organic matter content (Means, 1980) and significantly reduces biodegradation (Manilal and Alexander, 1991). The second phenomenon is slow mass transfer of pollutants, such as pore diffusion in the soil aggregates or diffusion in the organic matter in the soil. The complex set of these physical, chemical and biological processes is schematically illustrated in Figure 1. As shown in Figure 1, biodegradation processes are taking place in the soil solution while diffusion processes occur in the narrow pores in and between soil aggregates (Danielsson, 2000). Seemingly contradictory studies can be found in the literature that indicate the rate and final extent of metabolism may be either lower or higher for sorbed PAHs by soil than those for pure PAHs (Van Loosdrecht et al., 1990). These contrasting results demonstrate that the bioavailability of organic contaminants sorbed onto soil is far from being well understood. Besides bioavailability, there are several other factors influencing the rate and extent of biodegradation of PAHs in soil including microbial population characteristics, physical and chemical properties of PAHs and environmental factors (temperature, moisture, pH, degree of contamination). Figure 1: Schematic diagram showing possible rate-limiting processes during bioremediation of hydrophobic organic contaminants in a contaminated soil-water system (not to scale) (Danielsson, 2000). 1.5 Increasing the bioavailability of PAH in soil Attempts to improve the biodegradation of PAHs in soil by increasing their bioavailability include the use of surfactants , solvents or solubility enhancers.. However, introduction of synthetic surfactant may result in the addition of one more pollutant. (Wang and Brusseau, 1993).A study conducted by Mulder et al. showed that the introduction of hydropropyl-ß-cyclodextrin (HPCD), a well-known PAH solubility enhancer, significantly increased the solubilization of PAHs although it did not improve the biodegradation rate of PAHs (Mulder et al., 1998), indicating that further research is required in order to develop a feasible and efficient remediation method. Enhancing the extent of PAHs mass transfer from the soil phase to the liquid might prove an efficient and environmentally low-risk alternative way of addressing the problem of slow PAH biodegradation in soil.
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The thermometer-based global surface temperature time series (GST) commands a prominent role in the evidence for global warming, yet this record has considerable uncertainty. An independent record with better geographic coverage would be valuable in understanding recent change in the context of natural variability. We compiled the Paleo Index (PI) from 173 temperature-sensitive proxy time series (corals, ice cores, speleothems, lake and ocean sediments, historical documents). Each series was normalized to produce index values of change relative to a 1901–2000 base period; the index values were then averaged. From 1880 to 1995, the index trends significantly upward, similar to the GST. Smaller-scale aspects of the GST including two warming trends and a warm interval during the 1940s are also observed in the PI. The PI extends to 1730 with 67 records. The upward trend appears to begin in the early 19th century but the year-to-year variability is large and the 1730–1929 trend is small.
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von Maximilian Parmod [d.i. Max Apt]
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Vorbesitzer: Abraham Merzbacher
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BACKGROUND: Microsomal transfer protein inhibitors (MTPi) have the potential to be used as a drug to lower plasma lipids, mainly plasma triglycerides (TG). However, studies with animal models have indicated that MTPi treatment results in the accumulation of hepatic TG. The purpose of this study was to evaluate whether JTT-130, a unique MTPi, targeted to the intestine, would effectively reduce plasma lipids without inducing a fatty liver. METHODS: Male guinea pigs (n = 10 per group) were used for this experiment. Initially all guinea pigs were fed a hypercholesterolemic diet containing 0.08 g/100 g dietary cholesterol for 3 wk. After this period, animals were randomly assigned to diets containing 0 (control), 0.0005 or 0.0015 g/100 g of MTPi for 4 wk. A diet containing 0.05 g/100 g of atorvastatin, an HMG-CoA reductase inhibitor was used as the positive control. At the end of the 7th week, guinea pigs were sacrificed to assess drug effects on plasma and hepatic lipids, composition of LDL and VLDL, hepatic cholesterol and lipoprotein metabolism. RESULTS: Plasma LDL cholesterol and TG were 25 and 30% lower in guinea pigs treated with MTPi compared to controls (P < 0.05). Atorvastatin had the most pronounced hypolipidemic effects with a 35% reduction in LDL cholesterol and 40% reduction in TG. JTT-130 did not induce hepatic lipid accumulation compared to controls. Cholesteryl ester transfer protein (CETP) activity was reduced in a dose dependent manner by increasing doses of MTPi and guinea pigs treated with atorvastatin had the lowest CETP activity (P < 0.01). In addition the number of molecules of cholesteryl ester in LDL and LDL diameter were lower in guinea pigs treated with atorvastatin. In contrast, hepatic enzymes involved in maintaining cholesterol homeostasis were not affected by drug treatment. CONCLUSION: These results suggest that JTT-130 could have potential clinical applications due to its plasma lipid lowering effects with no alterations in hepatic lipid concentrations.
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Vorbesitzer: Bartholomaeusstift Frankfurt am Main
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33 Briefe zwischen Julius S. Bach und Max Horkheimer, 1937-1941; 1 Brief von Julius S. Bach an Mary von Meldelsohn, 28.08.1940; 24 Briefe zwischen Richard Bach und Max Horkheimer, 1938-1940; 1 Abschrift eines Briefes von Oscar W. Gross an Emil de Leuw, 1938; 1 Brief von A. Bailer an Mr. Iggersheimer, 01.05.1940; 1 Brief von Max Horkheimer an Bailliere, Tindall & Cox London, 05.07.1949; 1 Brief von Beatrix Baird an Max Horkheimer; 5 Briefe zwischen Leonard Balet und Max Horkheimer, 1938-1949; 2 Briefe zwischen John Simon Guggenheim Memorial Foundation New York und Max Horkheimer, 22.11.1948, 05.01.1949; 1 Brief von W. H. de Graaff, Ladislaus Bálint an Max Horkheimer, 11.05.1938; 6 Briefe zwischen Bank of Manhattan Company New York und Max Horkheimer, 1934-1935; 6 Briefe zwischen Ladislaus Bálint und Max Horkheimer, 1934-1935; 2 Briefe zwischen der Bank of the Manhatten Company in New York und Max Horkheimer, 14./15.11.1934; 5 Briefe zwischen der Bankers Trust Company und Max Horkheimer, 1934; 1 Brief von R. Bárány an Max Horkheimer, 05.05.1933; 5 Briefe zwischen Hans Baron und Max Horkheimer, 1936; 3 Briefe zwischen Salo W. Baron und Max Horkheimer, 1941-1942, 16.04.1940; 1 Brief zwischen A. Barratt Brown und Max Horkheimer, 01.10.1936;