Audit report on Washington County, Iowa for the year ended June 30, 2011

Audit report on Washington County, Iowa for the year ended June 30, 2011

Audit report on Decatur County, Iowa for the year ended June 30, 2011

Audit report on Decatur County, Iowa for the year ended June 30, 2011

Audit report on Webster County, Iowa for the year ended June 30, 2011

Audit report on Webster County, Iowa for the year ended June 30, 2011

Audit report on Harrison County, Iowa for the year ended June 30, 2011

Audit report on Harrison County, Iowa for the year ended June 30, 2011

Audit report on Monona County, Iowa for the year ended June 30, 2011

Audit report on Monona County, Iowa for the year ended June 30, 2011

Report on a special investigation of the Adair County Engineer’s Office for the period December 5, 2001 through December 31, 2011

Report on a special investigation of the Adair County Engineer’s Office for the period December 5, 2001 through December 31, 2011

Audit report on O’Brien County, Iowa for the year ended June 30, 2011

Audit report on O’Brien County, Iowa for the year ended June 30, 2011

Report on a special investigation of the Lyon County Engineer’s Office for the period August 1, 2006 through May 31, 2012

Report on a special investigation of the Lyon County Engineer’s Office for the period August 1, 2006 through May 31, 2012

Ultrastructural evidence of exosome secretion by progenitor cells in adult mouse myocardium and adult human cardiospheres.

The demonstration of beneficial effects of cell therapy despite the persistence of only few transplanted cells in vivo suggests secreted factors may be the active component of this treatment. This so-called paracrine hypothesis is supported by observations that culture media conditioned by progenitor cells contain growth factors that mediate proangiogenic and cytoprotective effects. Cardiac progenitor cells in semi-suspension culture form spherical clusters (cardiospheres) that deliver paracrine signals to neighboring cells. A key component of paracrine secretion is exosomes, membrane vesicles that are stored intracellularly in endosomal compartments and are secreted when these structures fuse with the cell plasma membrane. Exosomes have been identified as the active component of proangiogenic effects of bone marrow CD34(+) stem cells in mice and the regenerative effects of embryonic mesenchymal stem cells in infarcted hearts in pigs and mice. Here, we provide electron microscopic evidence of exosome secretion by progenitor cells in mouse myocardium and human cardiospheres. Exosomes are emerging as an attractive vector of paracrine signals delivered by progenitor cells. They can be stored as an "off-the-shelf" product. As such, exosomes have the potential for circumventing many of the limitations of viable cells for therapeutic applications in regenerative medicine.

Myéloradiculopathie chronique progressive chez un homme de 61 ans [Chronic progressive myeloradiculopathy in a 61-year-old man]

A painful worsening of known difficulties in walking led us to investigate a man who presented a spastic paraparesis. Radiological investigations had to be repeated three times before making a diagnosis of a right C6 spinal dural arteriovenous fistula after a 22-month follow-up. Knowing the mechanisms leading to spinal venous hypertension may explain the low yield of the early radiological investigations that should be repeated. The efficiency of the treatment depends on the severity of the presurgical neurologic manifestations.

Statuta synodalia Burdegalensia.

F. 1 et 11v Constitutiones synodales Gerardi de Malemort et Petri de Roncevaux, archiep. Burdigalensium. F. 16, 21 et 23 Conciles de Compiègne, 1238 (Mansi, XXIII, 485-496), Ruffec, 1258 (ibid., 983-988) et Cognac, 1262 (ibid., 1105-1110). F. 23v NICOLAS III, Bulle du 13 déc. 1279 ; cf. Potthast, Regesta, n° 21665. F. 24v Concile de Bourges, 1276 (Mansi, XXIV, 165-180). F. 32v Constitutiones Arnaldi de Chanteloup, archiep. Burdegalensis, 1326 et 1329. F. 34 Concile d'Angoulême, 1343, et constitutions synodales de Pierre de Luce, archev. de Bordeaux, 1343-1345. F. 36v Constitutions de 1356. F. 37v Constitutio Petri la Colre, vicarii gen. Burdegalensis. F. 40 Constitutiones Amanei de la Mothe, archiep. Burdegalensis, 1358. F. 56 Constitutiones. Gerardi de Malemort. F. 57 et 58 Constitutiones « domini Petri » et « domini A. ». F. 62 Concile de Périgueux, 1365.