940 resultados para service co-production
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"Jointly sponsored by the University of Illinois and the U.S. Department of Agriculture Forest Service."
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Cover title.
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Mode of access: Internet.
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Description based on: 1981.
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Mode of access: Internet.
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Mode of access: Internet.
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Biological and chemical pro ling of an Australian strain of the fungus Aspergillus unilateralis (MST-F8675), isolated from a soil sample collected near Mount Isa, Queensland, revealed a complex array of metabolites displaying broad chemotherapeutic properties. Noteworthy among these metabolites were a unique series of highly modified dipeptides aspergillazines A-E, incorporating a selection of unprecedented and yet biosynthetically related heterocyclic systems. Co-occurring with the aspergillazines was the recently described marine-derived fungal metabolite trichodermamide A (cf. penicillazine), whereas re-fermentation of A. unilateralis in NaCl (1%) enriched media resulted in co-production of the only other known example of this structure class, the marine-derived fungal metabolite trichodermamide B. Further investigation of A. unilateralis returned the known terrestrial fungal metabolite viridicatumtoxin as the cytotoxic and antibacterial principle, together with E-2-decenedioic acid, ferulic acid, (7E,7'E)-5,5'-diferulic acid and (7E,7'E)-8,5'-diferulic acid. The aromatic diacids have previously been reported from the chemical and enzymatic (esterase) treatment of plant cell wall material, with their isolation from A. unilateralis being their first apparent reported occurrence as natural products. Structures for all metabolites were determined by detailed spectroscopic analysis and, where appropriate, comparison to literature data and/or authentic samples.
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I offer a new cartography of ethical resistance. I argue that there is an uncharted interaction between managerial secrecy and organizational silence, which may exponentially increase the incidence of corruption in ways not yet understood. Current methods used to raise levels of moral conduct in business and government practice appear blind to this powerful duo. Extensive literature reviews of secrecy and silence scholarships form the background for an early stage conceptual layout of the co-production of secrecy and silence.
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This is a study of third sector organisations and organisational change resulting from European Union funding. While there is a growing body of research which shows how governmental funding can contribute to the organisational challenges that third sector organisations encounter, research on how European Union funding affects third sector organisations is limited. This thesis contributes towards closing this gap in knowledge by identifying a number of organisational changes which can be attributed to the use of European Union funding. A qualitative approach was taken to explore organisational change resulting from the use of URBAN II funding in nine third sector organisations which were studied in the context of the URBAN II programmes of Belfast, Berlin and Bristol. The conceptual framework for this study draws on organisation theory and resource dependence theory, together with concepts of co-production and multi-level governance. URBAN II funding was found to have affected organisational structures, processes, services, goals and participants, as well as the interactions of organisations with their external environment. In contrast to earlier research however, the findings from this study suggest that many of these organisational changes improved the capacity of third sector organisations to carry out their work. The cross-national comparison of the findings further showed that organisational impacts resulting from the use of URBAN II funding can vary significantly between different countries. Programme Managers were found to have played a critically important' role in enabling third sector organisations to obtain benefits from URBAN II funding. Many positive organisational changes arose from a close collaboration between Programme Managers and third sector organisations. Conversely, many negative organisational impacts were found to be due, not to the regulations associated with European funding, but primarily to the approach adopted by the Programme Managers and Local Development Partnerships towards engaging third sector organisations in programme delivery.
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Background: Pregnancy is characterized by an inflammatory-like process and this may be exacerbated in preeclampsia. The heme oxygenase (HO) enzymes generate carbon monoxide (CO) that induces blood vessel relaxation and biliverdin that acts as an endogenous antioxidant. Materials and Methods: We examined the expression and localization of HO-1 and HO-2 in normal and preeclamptic placenta using reverse transcription polymerase chain reaction (RT-PCR), RNase protection assay, immunoblotting and immunohistochemistry. In addition, the effect of HO activation on tumor necrosis factor-alpha (TNF) induced placental damage and on feto-placental circulation was studied. Results: We provide the first evidence for the role of HO as an endogenous placental factor involved with cytoprotection and placental blood vessel relaxation. HO-1 was significantly higher at term, compared with first trimester placentae indicating its role in placental vascular development and regulation. HO-1 predominantly localized in the extravascular connective tissue that forms the perivascular contractile sheath around the developing blood vessels. HO-2 was localized in the capillaries, as well as the villous stroma, with weak staining of trophoblast. Induction of HO-1 caused a significant attenuation of TNF-mediated cellular damage in placental villous explants, as assessed by lactate dehydrogenase leakage (p 0.01). HO-1 protein was significantly reduced in placentae from pregnancies complicated with preeclampsia, compared with gestationally matched normal pregnancies. This suggests that the impairment of HO-1 activation may compromise the compensatory mechanism and predispose the placenta to cellular injury and subsequent maternal endothelial cell activation. Isometric contractility studies showed that hemin reduced vascular tension by 61% in U46619-preconstricted placental arteries. Hemininduced vessel relaxation and CO production was inhibited by HO inhibitor, tin protoporphyrin IX. Conclusions: Our findings establish HO-1 as an endogenous system that offers protection against cytotoxic damage in the placenta, identifies the HO-CO pathway to regulate feto-placental circulation and provides a new approach to study the disease of preeclampsia.
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Biomass is the term given to naturally-produced organic matter resulting from photosynthesis, and represents the most abundant organic polymers on Earth. Consequently, there has been great interest in the potential exploitation of lignocellulosic biomass as a renewable feedstock for energy, materials and chemicals production. The energy sector has largely focused on the direct thermochemical processing of lignocellulose via pyrolysis/gasification for heat generation, and the co-production of bio-oils and bio-gas which may be upgraded to produce drop-in transportation fuels. This mini-review describes recent advances in the design and application of solid acid catalysts for the energy efficient upgrading of pyrolysis biofuels.
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This chapter investigates the conflicting demands faced by web designers in the development of social e-atmospherics that aim to encourage e-value creation, thus strengthening and prolonging market planning strategies. While recent studies have shown that significant shifts are occurring concerning the importance of users’ generated content by way of social e-communication tools (e.g. blogs), these trends are also creating expectations that social and cultural cues ought to become a greater part of e-atmospherics and e-business strategies. Yet, there is growing evidence that organizations are resisting such efforts, fearing that they will lose control of their e-marketing strategy. This chapter contributes to the theory and literature on online cross-cultural understanding and the impact website designers (meso-level) can have on improving the sustainability of e-business planning, departing from recent studies that focus mainly on firms’ e-business plans (macro-level) or final consumers (micro-level). A second contribution is made with respect to online behavior regarding the advancement of technologies that facilitate the development and shaping of new social e-atmospherics that affect users’ behavior and long term e-business strategies through the avoidance of traditional, formal decision making processes and marketing strategy mechanisms implemented by firms. These issues have been highlighted in the literature on the co-production and co-creation of value, which few organizations have thus far integrated in their strategic and pragmatic e-business plans. Drawing upon fifteen online interviews with web designers in the USA, as key non-institutional actors at the meso-level who are developing what future websites will be like, this chapter analyzes ways in which identifying points of resistance and conflicting demands can lead to engagement with the debate over the online co-creation of value and more sustainable future e-business planning. A number of points of resistance to the inclusion of more e-social atmospherics are identified, and the implications for web designers’ roles and web design planning are discussed along with the limitations of the study and potential future research for e-business studies.
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The quest for sustainable resources to meet the demands of a rapidly rising global population while mitigating the risks of rising CO2 emissions and associated climate change, represents a grand challenge for humanity. Biomass offers the most readily implemented and low-cost solution for sustainable transportation fuels, and the only non-petroleum route to organic molecules for the manufacture of bulk, fine and speciality chemicals and polymers. To be considered truly sustainable, biomass must be derived fromresources which do not compete with agricultural land use for food production, or compromise the environment (e.g. via deforestation). Potential feedstocks include waste lignocellulosic or oil-based materials derived from plant or aquatic sources, with the so-called biorefinery concept offering the co-production of biofuels, platform chemicals and energy; analogous to today's petroleum refineries which deliver both high-volume/low-value (e.g. fuels and commodity chemicals) and lowvolume/ high-value (e.g. fine/speciality chemicals) products, thereby maximizing biomass valorization. This article addresses the challenges to catalytic biomass processing and highlights recent successes in the rational design of heterogeneous catalysts facilitated by advances in nanotechnology and the synthesis of templated porous materials, as well as the use of tailored catalyst surfaces to generate bifunctional solid acid/base materials or tune hydrophobicity.
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Acknowledgments The investigation of the Bennachie Colony is part of a broader initiative called the Bennachie Landscape Project, a collaborative endeavour between the Bailies of Bennachie and the University of Aberdeen. To date, funding for the project has been generously provided by the Arts and Humanities Research Council (AHRC) in the form of a Connected Communities Grant (G. Noble PI) and more recently through a larger Development Grant (J. Oliver PI). The research that this paper is based on could not have been undertaken without the generous assistance of a large number of volunteers, university students and staff members. While it would be impossible to name everyone who has contributed, we would like to acknowledge the regular members of the “landscape group” whose infective enthusiasm for the project has provided a stimulating environment for learning and co-production. Particular thanks go to Jackie Cumberbirch, Barry Foster, Chris Foster, Angela Groat, David Irving, Alison Kennedy, Harry Leal, Ken Ledingham, Colin Miller, Iain Ralston, Colin Shepherd, Sue Taylor and Andrew Wainwright. Further assistance with fieldwork was provided by Ágústa Edwald, Patrycia Kupiec, Barbora Wouters, Óskar Sveinbjarnarson, members of Northlight Heritage and several cohorts worth of University of Aberdeen undergraduate and graduate students. We are indebted to the RCAHMS for assistance with plane table survey and to Óskar Sveinbjarnarson for help with mapping. Others have supported additional aspects of the Bennachie Landscape project or have provided specialist advice. Thanks go to Neil Curtis, Liz Curtis, Rowan Ellis, Marjory Harper, Siobhan Convery and the University of Aberdeen Special Collections staff. Access to undertake fieldwork was graciously provided by the Forestry Commission Scotland. Helpful comments on earlier drafts of this paper were provided by Barry and Chris Foster, Ken Ledingham, Collin Miller, Collin Shepherd, Sue Taylor, Andrew Wainwright and two anonymous reviewers.
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Acknowledgments The investigation of the Bennachie Colony is part of a broader initiative called the Bennachie Landscape Project, a collaborative endeavour between the Bailies of Bennachie and the University of Aberdeen. To date, funding for the project has been generously provided by the Arts and Humanities Research Council (AHRC) in the form of a Connected Communities Grant (G. Noble PI) and more recently through a larger Development Grant (J. Oliver PI). The research that this paper is based on could not have been undertaken without the generous assistance of a large number of volunteers, university students and staff members. While it would be impossible to name everyone who has contributed, we would like to acknowledge the regular members of the “landscape group” whose infective enthusiasm for the project has provided a stimulating environment for learning and co-production. Particular thanks go to Jackie Cumberbirch, Barry Foster, Chris Foster, Angela Groat, David Irving, Alison Kennedy, Harry Leal, Ken Ledingham, Colin Miller, Iain Ralston, Colin Shepherd, Sue Taylor and Andrew Wainwright. Further assistance with fieldwork was provided by Ágústa Edwald, Patrycia Kupiec, Barbora Wouters, Óskar Sveinbjarnarson, members of Northlight Heritage and several cohorts worth of University of Aberdeen undergraduate and graduate students. We are indebted to the RCAHMS for assistance with plane table survey and to Óskar Sveinbjarnarson for help with mapping. Others have supported additional aspects of the Bennachie Landscape project or have provided specialist advice. Thanks go to Neil Curtis, Liz Curtis, Rowan Ellis, Marjory Harper, Siobhan Convery and the University of Aberdeen Special Collections staff. Access to undertake fieldwork was graciously provided by the Forestry Commission Scotland. Helpful comments on earlier drafts of this paper were provided by Barry and Chris Foster, Ken Ledingham, Collin Miller, Collin Shepherd, Sue Taylor, Andrew Wainwright and two anonymous reviewers.