Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic transmission is associated with this illness, but direct observation of abnormalities of dopamine function in schizophrenia has remained elusive. We used a newly developed single photon emission computerized tomography method to measure amphetamine-induced dopamine release in the striatum of fifteen patients with schizophrenia and fifteen healthy controls. Amphetamine-induced dopamine release was estimated by the amphetamine-induced reduction in dopamine D2 receptor availability, measured as the binding potential of the specific D2 receptor radiotracer [123I] (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl) methyl]benzamide ([123I]IBZM). The amphetamine-induced decrease in [123I]IBZM binding potential was significantly greater in the schizophrenic group (-19.5 +/- 4.1%) compared with the control group (-7.6 +/- 2.1%). In the schizophrenic group, elevated amphetamine effect on [123I]IBZM binding potential was associated with emergence or worsening of positive psychotic symptoms. This result suggests that psychotic symptoms elicited in this experimental setting in schizophrenic patients are associated with exaggerated stimulation of dopaminergic transmission. Such an observation would be compatible with an abnormal responsiveness of dopaminergic neurons in schizophrenia.

Standardization, certification, maintenance, and dissemination of large scale engineering software systems : a panel discussion held as a part of the Second National Symposium on Computerized Structural Analysis and Design /

Includes bibliographical references

Performance tests for the evaluation of computerized gas chromatography/mass spectrometry equipment and laboratories /

"April 1980"--Cover.

Some performance effects of age and low blood alcohol levels on a computerized neuropsychological test.

Federal Aviation Administration, Office of Aviation Medicine, Washington, D.C.

Usage of computerized traffic case management systems. Volume I. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Spanish Colonial Research Center computerized index of Spanish colonial documents /

Shipping list no.: 91-722-P.

Effective placement of detectors for computerized traffic control summary report. Final report.

Texas Department of Transportation, Austin

Detector location for computerized arterial street sampling detectors.

Texas Department of Transportation, Austin

Exploring legal issues associated with the use of computerized driving records.

Mode of access: Internet.

Computerized allocation of police traffic services; a demonstration study. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Computerized allocation of police traffic services; reference volume I. Computer-sensor system description. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Computerized allocation of police traffic services; reference volume II. Accident data handbook. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Detection devices to optimize computerized traffic control. Final report.

Federal Highway Administration, Washington, D.C.