Hall Of Mirrors:piano quartet for young musicians

for piano, violin, violin or viola, cello

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014

G-protein coupled receptors (GPCRs) are the targets of over half of all prescribed drugs today. The UniProt database has records for about 800 proteins classified as GPCRs, but drugs have only been developed against 50 of these. Thus, there is huge potential in terms of the number of targets for new therapies to be designed. Several breakthroughs in GPCRs biased pharmacology, structural biology, modelling and scoring have resulted in a resurgence of interest in GPCRs as drug targets. Therefore, an international conference, sponsored by the Royal Society, with world-renowned researchers from industry and academia was recently held to discuss recent progress and highlight key areas of future research needed to accelerate GPCR drug discovery. Several key points emerged. Firstly, structures for all three major classes of GPCRs have now been solved and there is increasing coverage across the GPCR phylogenetic tree. This is likely to be substantially enhanced with data from x-ray free electron sources as they move beyond proof of concept. Secondly, the concept of biased signalling or functional selectivity is likely to be prevalent in many GPCRs, and this presents exciting new opportunities for selectivity and the control of side effects, especially when combined with increasing data regarding allosteric modulation. Thirdly, there will almost certainly be some GPCRs that will remain difficult targets because they exhibit complex ligand dependencies and have many metastable states rendering them difficult to resolve by crystallographic methods. Subtle effects within the packing of the transmembrane helices are likely to mask and contribute to this aspect, which may play a role in species dependent behaviour. This is particularly important because it has ramifications for how we interpret pre-clinical data. In summary, collaborative efforts between industry and academia have delivered significant progress in terms of structure and understanding of GPCRs and will be essential for resolving problems associated with the more difficult targets in the future.

Predicting intention to work with social robots

The growing number of robotic solutions geared to interact socially with humans, social robots, urge the study of the factors that will facilitate or hinder future human robot collaboration. Hence the research question: what are the factors that predict intention to work with a social robot in the near future. To answer this question the following socio-cognitive models were studied, the theory of reasoned action, the theory of planned behavior and the model of goal directed behavior. These models purport that all the other variables will only have an indirect effect on behavior. That is, through the variables of the model. Based on the research on robotics and social perception/ cognition, social robot appearance, belief in human nature uniqueness, perceived warmth, perceived competence, anthropomorphism, negative attitude towards robots with human traits and negative attitudes towards interactions with robots were studied for their effects on attitude towards working with a social robot, perceived behavioral control, positive anticipated emotions and negative anticipated emotions. Study 1 identified the social representation of robot. Studies 2 to 5 investigated the psychometric properties of the Portuguese version of the negative attitude towards robots scale. Study 6 investigated the psychometric properties of the belief in human nature uniqueness scale. Study 7 tested the theory of reasoned action and the theory of planned behavior. Study 8 tested the model of goal directed behavior. Studies 7 and 8 also tested the role of the external variables. Study 9 tested and compared the predictive power of the three socio-cognitive models. Finally conclusion are drawn from the research results, and future research suggestions are offered.

Statue of Hon. John C. Calhoun erected in Statuary Hall of the Capitol at Washington ; proceedings in Statuary Hall and in the Senate and the House of Representatives on the occasion of the unveiling, reception, and acceptance of the statue from the State of South Carolina / compiled under the direction of the Joint Committee on printing

This publication is the proceedings of the unveiling ceremony for the statue of John C. Calhoun in the Statuary Hall in Washington D.C.

Catalogue of articles on exhibition at the second annual fair of the South-Carolina Institute, at the Military hall, November, 1850

This document contains a catalogue of the articles on exhibition at the 1850 annual fair of the South Carolina Institute. It includes 337 items exhibited at the fair in Charleston at the Military Hall.

An address delivered in the Indigo Hall, Georgetown, South Carolina, on the fourth day of May, 1860, the 105th anniversary of the Winyaw Indigo Society

This pamphlet presents the text of the address given by Plowden C.J. Weston on May 4, 1860 to the Winyaw Indigo Society on their 105th anniversary.

Mr [James] O'Grady arrivant à Caxton Hall [membre du Parlement anglais et secrétaire de la National Federation of General Workers] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56233

Grève des cheminots anglais, Mr Arthur Henderson [secrétaire du Labor party] quittant Caxton Hall : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56234

[16/7/20, salle de l'Albert Hall de Londres] match [de boxe entre] Tommy Burns [et Joe] Beckett : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 60155

[16/7/20, salle de l'Albert Hall de Londres] match [de boxe entre] Tommy Burns [et Joe] Beckett : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 60156