988 resultados para Wigan, Arthur Cleveland, b. 1815,


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This collection consists of black and white photographs autographed by the entertainers who performed at Winthrop College as part of the institution’s Artist Series program, a photograph of the Winthrop College Poetry Society including Dr. David B. Johnson, founder and first president of Winthrop, and photographs of Walter B. Roberts and other Winthrop College Professors as well as visiting instructors from Julliard School of Music. Artists include Jasha Heifetz, Jan Peerce, Will Rogers, Arthur Rubenstein, Risë Stevens, Vienna Choir Boys and many others.

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Linezolid (LZD)-resistant Staphylococcus aureus (LRSA) isolates were monitored from 2000 to 2009 in Cleveland, OH. LRSA first emerged in 2004 only in cystic fibrosis (CF) patients, with 11 LRSA-infected CF patients being identified by 2009. LRSA was isolated from 8 of 77 CF patients with S. aureus respiratory tract infection treated with LZD from 2000 to 2006. Analysis of clinical data showed that the 8 CF patients with LRSA received more LZD courses (18.8 versus 5.9; P = 0.001) for a longer duration (546.5 versus 211.9 days; P < 0.001) and had extended periods of exposure to LZD (83.1 versus 30.1 days/year; P < 0.001) than the 69 with LZD-susceptible isolates. Five LRSA isolates included in the clinical analysis (2000 to 2006) and three collected in 2009 were available for molecular studies. Genotyping by repetitive extrapalindromic PCR and pulsed-field gel electrophoresis revealed that seven of these eight LRSA strains from unique patients were genetically similar. By multilocus sequence typing, all LRSA isolates were included in clonal complex 5 (seven of sequence type 5 [ST5] and one of ST1788, a new single-locus variant of ST5). However, seven different variants were identified by spa typing. According to the Escherichia coli numbering system, seven LRSA isolates contained a G2576T mutation (G2603T, S. aureus numbering) in one to four of the five copies of domain V of the 23S rRNA genes. One strain also contained a mutation (C2461T, E. coli numbering) not previously reported. Two strains, including one without domain V mutations, possessed single amino acid substitutions (Gly152Asp or Gly139Arg) in the ribosomal protein L3 of the peptidyltransferase center, substitutions not previously reported in clinical isolates. Emergence of LRSA is a serious concern for CF patients who undergo prolonged courses of LZD therapy.

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Background & Aims: HLA-B27 is associated with spontaneous HCV genotype 1 clearance. HLA-B27-restricted CD8+ T cells target three NS5B epitopes. Two of these epitopes are dominantly targeted in the majority of HLA-B27+ patients. In chronic infection, viral escape occurs consistently in these two epitopes. The third epitope (NS5B2820) was dominantly targeted in an acutely infected patient. This was in contrast, however, to the lack of recognition and viral escape in the large majority of HLA-B27+ patients. Here, we set out to determine the host factors contributing to selective targeting of this epitope. Methods: Four-digit HLA class I typing and viral sequence analyses were performed in 78 HLA-B27+ patients with chronic HCV genotype 1 infection. CD8+ T cell analyses were performed in a subset of patients. In addition, HLA/peptide affinity was compared for HLA-B27:02 and 05. Results: The NS5B2820 epitope is only restricted by the HLA-B27 subtype HLA-B27:02 (that is frequent in Mediterranean populations), but not by the prototype HLA-B27 subtype B27:05. Indeed, the epitope is very dominant in HLA-B27:02+ patients and is associated with viral escape mutations at the anchor position for HLA-binding in 12 out of 13 HLA-B27:02+ chronically infected patients. Conclusions: The NS5B2820 epitope is immunodominant in the context of HLA-B27:02, but is not restricted by other HLA-B27 subtypes. This finding suggests an important role of HLA subtypes in the restriction of HCV-specific CD8+ responses. With minor HLA subtypes covering up to 39% of specific populations, these findings may have important implications for the selection of epitopes for global vaccines.

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von I. M. Jost

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Bd 9 u. 10 sind nicht im Freimann-Kat. aufgeführt

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Aus: Archiv für das Studium der neueren Sprachen und Literaturen. Bd 122, 1909

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40 Briefe zwischen Arthur E. Nadel und Max Horkheimer, 1934-1939; 1 Brief von Arthur E. Nadel an Armin Hodler, 02.02.1939; 18 Briefe zwischen Otto Nathan und Max Horkheimer, 1934-1940; 1 Brief von Friedrich Pollock an Paul Tillich, 12.11.1938; 5 Briefe zwischen dem National Council of Jewish Women New York Section und Max Horkheimer, 1937-1939; 1 Brief vom National Council of Parent Education Poughkeepsie, New York an Max Horkheimer, 17.06.1940; 1 Brief vom National Research Council Washington an Max Horkheimer, 15.02.1941; 2 Briefe zwischen dem National Roster of Scientific and Specialized Personnel Washington und Max Horkheimer, 1940; 2 Briefe zwischen Lisel Nädele und Max Horkheimer, 11.12.1939, 22.01.1940; 1 Brief von Benjamin Nathaniel Nelson an Max Horkheimer, 20.04.1938 sowie Briefwechsel mit der C.R.B. Educational Foundation, New York; 2 Briefe zwischen der C.R.B. Educational Foundation, New York und Max Horkheimer, 16.12.1937; 1 Brief von Max Horkheimer an Neumann, 08.07.1934; 3 Briefe und Beilage zwischen Fritz Neumark, Jenny Neumark und Max Horkheimer, 08.08.1939 sowie Briefwechsel mit Otto Strauß; 2 Briefe zwischen Otto Strauß vom Selfhelp for German Emigree New York und Max Horkheimer, 01.08.1939, 04.08.1939;

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u.a.: Brief von Gottlieb Wilhelm Skerle; Mutter-Sohn-Konflikt;

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u.a.: Finanzschwierigkeiten des Verlags; Krankeit von Johanna Schopenhauer; Kuraufenthalt;

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u.a.: Verstopfung; Wassersucht; Kur in Karlsbad; Krankheit von Adele Schopenhauer; Erbschaftsangelegenheiten; Bankhaus Muhl;

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u.a.: Bankhaus Muhl; Mutter von Johanna Schopenhauer; Erbschafssache Andreas Schopenhauer; Immobilien;