A pintura de Jesuíno do Monte Carmelo na Igreja da Ordem Terceira do Carmo em São Paulo

Pós-graduação em Artes - IA

Costa Rica: intermediación financiera y asignación de recursos

Incluye Bibliografía

A Marmota na Corte: recreação e vereda literária no cenário cultural do século XIX (1849-1852)

Pós-graduação em Letras - FCLAS

Effects of oestrogen deficiency and 17 beta-estradiol therapy on bone healing in calvarial critical size defects treated with bovine bone graft

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A pintura de Jesuíno do Monte Carmelo em São Paulo e Itu: busca dos referenciais iconográficos e novas considerações

Pós-graduação em Artes - IA 33004013063P4

The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets

Background The malignant B cells in chronic lymphocytic leukemia receive signals from the bone marrow and lymph node microenvironments which regulate their survival and proliferation. Characterization of these signals and the pathways that propagate them to the interior of the cell is important for the identification of novel potential targets for therapeutic intervention. Design and Methods We compared the gene expression profiles of chronic lymphocytic leukemia B cells purified from bone marrow and peripheral blood to identify genes that are induced by the bone marrow microenvironment. Two of the differentially expressed genes were further studied in cell culture experiments and in an animal model to determine whether they could represent appropriate therapeutic targets in chronic lymphocytic leukemia. Results Functional classification analysis revealed that the majority of differentially expressed genes belong to gene ontology categories related to cell cycle and mitosis. Significantly up-regulated genes in bone marrow-derived tumor cells included important cell cycle regulators, such as Aurora A and B, survivin and CDK6. Down-regulation of Aurora A and B by RNA interference inhibited proliferation of chronic lymphocytic leukemia-derived cell lines and induced low levels of apoptosis. A similar effect was observed with the Aurora kinase inhibitor VX-680 in primary chronic lymphocytic leukemia cells that were induced to proliferate by CpG-oligonucleotides and interleukin-2. Moreover, VX-680 significantly blocked leukemia growth in a mouse model of chronic lymphocytic leukemia. Conclusions Aurora A and B are up-regulated in proliferating chronic lymphocytic leukemia cells and represent potential therapeutic targets in this disease.

Tramas impresas : Publicaciones periódicas argentinas (XIX-XX)

Tabla de contenidos: Algunas cuestiones críticas y metodológicas en relación con el estudio de revistas / Verónica Delgado. El estudio de revistas culturales en la era de las humanidades digitales. Reflexiones metodológicas para un debate / Hanno Ehrlicher. La prensa en red: los periódicos de Francisco de Paula Castañeda / Claudia Roman. Leer (con) imágenes. Litografías y prensa periódica en los procesos de lectura y escritura a mediados del siglo XIX en el Río de la Plata / Hernán Pas. El Sud Americano. Notas para una historia material y visual de la prensa periódica ilustrada en el siglo XIX / Sandra M. Szir. El momento continentalista de Lugones: la Revue Sud-Américaine (1914) / Margarita Merbilhaá. Las biografías de hombres de ciencia en el proyecto intelectual de la Revista de Filosofía / Cristina Beatriz Fernández. Imagen y consumo en la Atlántida de los años veinte / Talía Bermejo. Para iluminar el sexo y el cuerpo. Revista Cultura Sexual y Física de Editorial Claridad / Laura Fernández Cordero. Escrituras de un lector de revistas y periódicos: los cuadernos de Angel Nuñez (1919-1920) / Geraldine Rogers. Enfrentamientos periodísticos en los comienzos de Noticias Gráficas / Sylvia Saítta. Suplemento de literatura: cultura impresa y ficción en la Revista Multicolor de los Sábados / María de los Angeles Mascioto. La revista Qué: prácticas editoriales y filiaciones estéticas en el inicio del surrealismo argentino / Armando V. Minguzzi. Las representaciones del magisterio en la prensa oficial: El Monitor de la Educación, 1900-1930 / Flavia Fiorucci. Gaceta Literaria: un artefacto editorial y una revista de pasaje en la trama de la cultura comunista latinoamericana de los años '50 / Adriana Petra. Desde La Plata hacia el mundo a través de Diagonal Cero / Silvia Dolinko. Los Libros: del estructuralismo al isabelismo con una escala latinoamericana / Marcela Croce. Las relaciones entre discurso crítico y política en la revista Los Libros / Fabio Espósito.

Disruption of abscisic acid signaling constitutively activates Arabidopsis resistance to the necrotrophic fungus Plectosphaerella cucumerina.

Plant resistance to necrotrophic fungi is regulated by a complex set of signaling pathways that includes those mediated by the hormones salicylic acid (SA), ethylene (ET), jasmonic acid (JA), and abscisic acid (ABA). The role of ABA in plant resistance remains controversial, as positive and negative regulatory functions have been described depending on the plant-pathogen interaction analyzed. Here, we show that ABA signaling negatively regulates Arabidopsis (Arabidopsis thaliana) resistance to the necrotrophic fungus Plectosphaerella cucumerina. Arabidopsis plants impaired in ABA biosynthesis, such as the aba1-6 mutant, or in ABA signaling, like the quadruple pyr/pyl mutant (pyr1pyl1pyl2pyl4), were more resistant to P. cucumerina than wild-type plants. In contrast, the hab1-1abi1-2abi2-2 mutant impaired in three phosphatases that negatively regulate ABA signaling displayed an enhanced susceptibility phenotype to this fungus. Comparative transcriptomic analyses of aba1-6 and wild-type plants revealed that the ABA pathway negatively regulates defense genes, many of which are controlled by the SA, JA, or ET pathway. In line with these data, we found that aba1-6 resistance to P. cucumerina was partially compromised when the SA, JA, or ET pathway was disrupted in this mutant. Additionally, in the aba1-6 plants, some genes encoding cell wall-related proteins were misregulated. Fourier transform infrared spectroscopy and biochemical analyses of cell walls from aba1-6 and wild-type plants revealed significant differences in their Fourier transform infrared spectratypes and uronic acid and cellulose contents. All these data suggest that ABA signaling has a complex function in Arabidopsis basal resistance, negatively regulating SA/JA/ET-mediated resistance to necrotrophic fungi.

Fiestas centenarias, con que la insigne, noble, leal, y coronada ciudad de Valencia celebrò en el dia 9 de Octubre de 1738. La quinta centuria de su christiana conquista

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Hechos, trabajos y martirio, ó admirable vida, y preciosa muerte del venerable ... Jacinto Castañeda y Pujazons ... de la ... Orden de Predicadores

Contiene: Alocución de Nuestro Santisimo Padre Pio ... Papa VI ... día 13 de Noviembre de 1775 ..., p. 269-288

Por la Ciudad de Alicante y Gines Gosaluez escriuano... y iurados de dicha Ciudad con el dotor Victoriano Tredos y Pasqual

Sign.: A-F2, G3

Descripcion de los ornatos públicos con que la Corte de Madrid ha solemnizado la feliz exâltacion al trono de los reyes nuestros señores Don Carlos III [sic], y Doña Luisa de Borbon, y la jura del ... Señor Don Fernando, Principe de Asturias

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Demostracion juridica de la justicia que assiste al Dr. D. Joseph Martin Gil ... en el pleyto que en grado de revista sigue con la religion de S. Juan de Jerusalen y Frey D. Silverio Dos sobre que se mejore la sentencia de vista, y ... se le de por libre del reconocimiento, o Cabreve de la Alqueria, y diez cahizadas y media de tierra, sitas en el realengo de esta ciudad [de Torrente], partida de la Foya de Enguerret

Precede al tít.: "Jesus, Maria y Joseph y S. Francisco de Paula"

Espresion de en-horabuena para el ... Marques de Albaida, por los honores, i tratamiento de Grande de España : que le ha concedido el rei ... en ocasion del Nacimiento del ... infante D. Carlos Clemente de Borbon ...

Sign. : [ ]2, *4