Prediction of psychosis in clinical high-risk patients by the Schizotypal Personality Questionnaire. Results of the EPOS project

OBJECTIVE: Schizotypal features indicate proneness to psychosis in the general population. It is also possible that they increase transition to psychosis (TTP) among clinical high-risk patients (CHR). Our aim was to investigate whether schizotypal features predict TTP in CHR patients. METHODS: In the EPOS (European Prediction of Psychosis Study) project, 245 young help-seeking CHR patients were prospectively followed for 18 months and their TTP was identified. At baseline, subjects were assessed with the Schizotypal Personality Questionnaire (SPQ). Associations between SPQ items and its subscales with the TTP were analysed in Cox regression analysis. RESULTS: The SPQ subscales and items describing ideas of reference and lack of close interpersonal relationships were found to correlate significantly with TTP. The co-occurrence of these features doubled the risk of TTP. CONCLUSIONS: Presence of ideas of reference and lack of close interpersonal relations increase the risk of full-blown psychosis among CHR patients. This co-occurrence makes the risk of psychosis very high.

Cannabis use and age at onset of symptoms in subjects at clinical high risk for psychosis

Numerous studies have found a robust association between cannabis use and the onset of psychosis. Nevertheless, the relationship between cannabis use and the onset of early (or, in retrospect, prodromal) symptoms of psychosis remains unclear. The study focused on investigating the relationship between cannabis use and early and high-risk symptoms in subjects at clinical high risk for psychosis.

Limited predictive value of FDG-PET for response assessment in the preoperative treatment of esophageal cancer: results of a prospective multi-center trial (SAKK 75/02)

BACKGROUND: Only responding patients benefit from preoperative therapy for locally advanced esophageal carcinoma. Early detection of non-responders may avoid futile treatment and delayed surgery. PATIENTS AND METHODS: In a multi-center phase ll trial, patients with resectable, locally advanced esophageal carcinoma were treated with 2 cycles of induction chemotherapy followed by chemoradiotherapy (CRT) and surgery. Positron emission tomography with 2[fluorine-18]fluoro-2-deoxy-d-glucose (FDG-PET) was performed at baseline and after induction chemotherapy. The metabolic response was correlated with tumor regression grade (TRG). A decrease in FDG tumor uptake of less than 40% was prospectively hypothesized as a predictor for histopathological non-response (TRG > 2) after CRT. RESULTS: 45 patients were included. The median decrease in FDG tumor uptake after chemotherapy correlated well with TRG after completion of CRT (p = 0.021). For an individual patient, less than 40% decrease in FDG tumor uptake after induction chemotherapy predicted histopathological non-response after completion of CRT, with a sensitivity of 68% and a specificity of 52% (positive predictive value 58%, negative predictive value 63%). CONCLUSIONS: Metabolic response correlated with histopathology after preoperative therapy. However, FDG-PET did not predict non-response after induction chemotherapy with sufficient clinical accuracy to justify withdrawal of subsequent CRT and selection of patients to proceed directly to surgery.

Der Jüden Glaube und Aberglaube ...

von Friedrich Albrecht Christiani ... wie auch einer Vorrede ... ausgefertigt von Christiano Reineccio

Anti-Israel : eine Vorlesung in d. geheimen Akademie zum grünen Esel als Entrittsrede

geh. von Horatius Cocles [d.i. Karl Christian Ernst Graf von Benzel-Sternau]

Der grosse Prophet : ein Mahn- u. Abschiedswort an meine antisemit. Freunde

von [A.] Stein

Geschichte der Juden in der Reichsstadt Augsburg

[Verf.[[Elektronische Ressource]] : Paul von Stetten]

Geschichte der Juden in Baiern

Joh. Christ. Frh. von Aretin

Der vertheidigte Korn-Jude

von Johann Albrecht Philippi. Mit Kupfern

[Über Hausverkauf]

... decretum Hanau den 2. Juli 1802 Kurfürstl. Hess. Regierung hierselbst

Beitrag zum Entwurf der zu vereinbarenden Verfassung: Das Wahlgesetz: ob Urwahl? - ob Wahl nach Ständen? - ob Census? : Sr. Majestät dem Könige und Einer Hohen National-Versammlung ehrerbietigst gewidmet

Boberach: Das Zensuswahlrecht wird historisch und politisch begründet; mit ihm erhalten die Arbeitgeber die Möglichkeit, die wirtschaftliche Entwicklung so zu fördern, daß davon auch die besitzlosen Klassen profitieren

Die Nothwendigkeit und Heiligkeit des Absolutismus : ein Morgengruß

Boberach: Preußen soll an sich selber denken, statt sich mit deutscher Politik aufzuhalten, und zum Absolutismus zurückkehren, da die Entwicklung in Sachsen von 1830 bis 1849 die Gefahren des Konstitutionalismus zeigt und die Demokraten politisch gescheitert sind

Die Schleswig-Holsteinische Frage

Boberach: Eine Untersuchung der Ursachen der Auseinandersetzung mit Dänemark, dessen politische Ziele berechtigt sind, wenn auch nicht die angewandten Methoden, führt zu dem Ergebnis, daß nur die Abtretung von Nordschleswig an Dänemark zu einem dauerhaften Frieden führen kann; darauf soll Preußen hinwirken