Uso de compostos derivados ftalimídicos e/ou sulfonamídicos no tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-alfa e a necessidade de uma fonte exógena de óxido nítrico, compostos derivados ftalimídicos, compostos derivados sulfonamídicos, método de obtenção de um composto derivado sulfonamídico

A presente invenção se refere ao uso de compostos derivados ftalimídicos e/ou sulfonamídicos com propriedades doadoras de óxido nítrico, os quais apresentam importantes atividades no aumento da expressão gênica de gama globina e atividades antiinflamatórias e analgésicas, potenciais ao tratamento de doenças hematológicas em que há a necessidade de diminuição dos níveis do fator TNF-<244> e a necessidade de uma fonte exógena de óxido nítrico. Mais particularmente, a presente invenção descreve o uso de tais derivados ftalimídicos e/ou sulfonamídicos para o tratamento de anemia falciforme. A invenção também apresenta como característica inovadora, a descrição de novos derivados ftalimídicos funcionalizados, desenhados a partir dos protótipos talidomida e hidroxiuréia e planejados racionalmente através da estratégia de hibridação molecular para o tratamento das doenças citadas. A invenção apresenta ainda um novo método de obtenção de um derivado sulfonamídico específico que pode ser utilizado na preparação de um medicamento para tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-<244> e a necessidade de uma fonte exógena de óxido nítrico.

Uso de compostos derivados ftalimidicos e/ou sulfonamídicos no tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-alpha e a necessidade de uma fonte exógena de óxido nítrico, compostos derivados sulfonamídicos. Método de obtenção de um composto derivado sulfonamídico

Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-[alpha] levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.

Estimativa da necessidade de nitrogênio em cobertura no feijoeiro IAC Alvorada com clorofilômetro portátil

The aims of this study was evaluated the efficiency of nitrogen sufficiency index (NSI) calculated with base on the measures relative chlorophyll index (RCI) leaves, measured with portable chlorophyll meter, as an indicator of time of sidedressing N fertilization and verify which value of NSI (90% and 95%) is the most appropriate to indicate the moment of N fertilization on common bean cultivar IAC Alvorada. An experiment with five N managements (M1: 200 kg ha(-1) N (40 kg at sowing + 80 kg at 15 days after emergency (DAE) + 80 kg 30 DAE); M2: 100 kg ha(-1) N (20 kg at sowing + 40 kg at 15 DAE + 40 kg at 30 DAE); M3: 20 kg ha(-1) N at sowing + 30 kg ha(-1) when chlorophyll meter readings indicated NSI < 95%; M4: 20 kg ha(-1) N at sowing + 30 kg N ha(-1) N when chlorophyll meter readings indicated NSI <90% and, M5: control (without N application)) and four replications was carried out in the rainy and dry growing seasons of the agricultural year 2009/10, in Botucatu, Sao Paulo State, Brazil. The variables RCI, aboveground dry matter, leaf N concentration, yield components, grain yield, and N use efficiency were evaluated. The NSI of 90%, calculated based on monitoring of RCI in common bean leaves with chlorophyll meter, was more effective than 95% to define need for N sidedressing in common bean cultivar IAC Alvorada, reducing the N application and improving the use efficiency of applied N.

A alfabetização sob o olhar da Teoria Histórico Cultural: sobre a necessidade e a atividade de estudo

Studies on activity and learning in the cultural-historical approach involves, most cases, the discussions on the higher psychological functions and areas of proximal and real development. Having said that our objective in this paper is to make a discussion about the activity of study and the concepts that involve the teaching of the mother language from the Historic-Cultural theory. We point this way, the importance of this approach in studies on literacy and knowledge of the activity of study as central to the creation of humanizing need of reading and writing, starting from the principle that the creation of needs requires the production of discourses, which have their materiality in the text.

Cri-an-ça: a criatividade, a infância e a imaginação expressadas no desenho (porque os adultos têm sempre necessidade de explicações detalhadas)

O interesse por esta temática de trabalho surgiu a partir de um estudo realizado em minha iniciação científica, que tem por título “Ação, Câmera, Luz: Entre imagens e olhares – experiência de infâncias e montagens” desenvolvido no Departamento de Educação do Instituto de Biociências, localizado na Universidade Estadual Paulista – UNESP/Rio Claro. Como o próprio título sugere, ela tem por principal objetivo inverter a lógica da conhecida frase: “Luz, Câmera, Ação”. Este trabalho, ao inverter a ordem dos fatores, busca ver se ao deixarmos a ação das crianças livre, o que se produziria seria algo mais verdadeiro, mais significativo, de fato. O que a ausência de intencionalidade geraria aos produtores de imagens. A partir de então, comecei a imaginar outro tipo de produção de imagens, não mais com câmeras fotográficas e filmadoras, mas de próprio punho. Portanto, este trabalho tem por objetivo analisar as crianças, e suas realidades através do que elas mesmas nos dizem e nos mostram em seu dia a dia por meio de seus desenhos. Os desenhos utilizados foram retirados de uma instituição de ensino não formal da cidade de Rio Claro, e entendidos como documentos. A pesquisa traz também um aporte teórico com as concepções sobre desenho infantil de alguns teóricos, como Lowenfel, Greig, La Pastina, Vigotski entre outros

Estudo sobre a necessidade e preferência sobre orientações de enfermagem ao paciente oncológico adulto em quimioterapia

Most cancer types are treated by antineoplastic chemotherapy, which can be performed conjointly with other treatments, such as radiotherapy and surgery. Due to its action, chemotherapy provides the possibility of cure, but it also leads to a number of adverse effects, such as myelosuppression, cutaneous and gastrointestinal toxicity, etc. Patients undergoing chemotherapy must receive constant information concerning how to prevent or minimize these effects in order to achieve better quality of life and, consequently, a more successful treatment. Hence, this study aimed at investigating the need and preference for different forms of information by oncologic patients submitted to chemotherapy. It is a cross-sectional, descriptive and quantitative study conducted at the chemotherapy division of the Botucatu School of Medicine University Hospital/SP on a sample of 50 patients older than 18 years. After previous knowledge of the study and formalization of Free Consent, the individuals answered a questionnaire containing 12 questions related to the importance attributed to the information received, from which professional and when to receive it. Data were analyzed by Fisher’s exact test and showed that 62% of the patients were females, and the remaining 38% were males of whom 46% were older than 60 years, 26% were from 50 to 60 years old, 24% from 30 to 50, and only 4% were younger than 30 years old. The patients had lymphatic (23.4%) and solid (76.6%) tumors. All the respondents reported that receiving information about the disease and its treatment was extremely important. As regards information related to side effects, 98% of patients answered that receiving it was extremely important, and only 2% answered that it was little important. Correlations were made between age, gender, and tumor type with the answers obtained for the best moment, how and from whom to receive such informatio... (Complete abstract click electronic access below)

A emergência da necessidade formativa docente no campo discursivo da formação de professores no Brasil

Pós-graduação em Educação - FCT

Quebra espontânea de simetria de gauge: necessidade e (im)possibilidade

In this work we make an introduction to Lattice Gauge Theory, focusing on the Elitzur Theorem about the expected value of not gauge invariant local observables. Finally, after the exposure of the main facts of the theory, we make an extension to semilocal models

A necessidade da formação da consciência ambiental na sociedade contemporânea: um estudo sobre as relações dialéticas entre o ser humano, a natureza e a cultura na obra de Ítalo Calvino

The present work has for objective to analyze the issue of training environmental awareness and its role in contemporary society. With the alarming scenario of degradation and environmental imbalance , political, social and non-governmental institutions have established the urgent need for an education that make changes in social behavior in relation to the environment. With this design is establishing environmental education, however the economic , financial and social scenario in which is inserted dismantles its effectiveness , since the transformations of modernity incited alienation, reification , individualization , indifference and consumerism . In this juncture it is noticed that environmental education needs to be analyzed by the perspective of a man in critical reflection of the capitalist structure. Given this need , it is proposed to reading Italo Calvino's work , since it approach the whole context of modern man , with his ailments , anxiety, exploitation , selfishness and destructive action of itself, others and the environment in living

Necessidade de ancoragem do grupo A e o controle biomecanico da mola T pré-ativada por curvatura para o fechamento de espacos

Contemporary orthodontics has sought, beyond the esthetic, occlusal and functional goals, treatments even faster and with less visits to the orthodontist — especially in patients that require dental extractions in which the generated space becomes a nuisance. The segmented arch technic (SAT), by the use of a "T" loop spring, has provided such results within these requirements. Therefore, this study aimed to appraise and demonstrate the confection, activation and biomechanical control of "T" loop spring, in the group with high anchorage necessity (group A), for retraction of anterior teeth; as well as to present a case report, with high anterior retraction necessity, treated with "T" loop spring.

Razão e paixão: necessidade e contingência na construção da vida ética

This text, essayistic character, aims to make some reflections on the dispute or supposed conflict that exists between two elements that have become essential in the constitution of the philosophical domain, in order to assess their contribution in the ethical field. On the one hand, we find the rational dimension, which is marked and has acquired certain predominance in western thought. On the other hand, the dimension of passion, that throughout the history of philosophy, has been subject to exclusion and devaluation, making it as if it were an obstacle to the formulation of ideas and universal values true and substantial. If one looks at the world seeing them or giving it a necessary and essential character, the other tends to recognize the contingent aspect of reality, seeing in it the possibility of accidental and uncertain.