Microsatellites provide evidence for Y chromosome diversity among the founders of the New World

Recently, Y chromosome markers have begun to be used to study Native American origins. Available data have been interpreted as indicating that the colonizers of the New World carried a single founder haplotype. However, these early studies have been based on a few, mostly complex polymorphisms of insufficient resolution to determine whether observed diversity stems from admixture or diversity among the colonizers. Because the interpretation of Y chromosomal variation in the New World depends on founding diversity, it is important to develop marker systems with finer resolution. Here we evaluate the hypothesis of a single-founder Y haplotype for Amerinds by using 11 Y-specific markers in five Colombian Amerind populations. Two of these markers (DYS271, DYS287) are reliable indicators of admixture and detected three non-Amerind chromosomes in our sample. Two other markers (DYS199, M19) are single-nucleotide polymorphisms mostly restricted to Native Americans. The relatedness of chromosomes defined by these two markers was evaluated by constructing haplotypes with seven microsatellite loci (DYS388 to 394). The microsatellite backgrounds found on the two haplogroups defined by marker DYS199 demonstrate the existence of at least two Amerind founder haplotypes, one of them (carrying allele DYS199 T) largely restricted to Native Americans. The estimated age and distribution of these haplogroups places them among the founders of the New World.

Obesidade e genes candidatos: estudo de associação em populações quilombolas do Vale do Ribeira-SP

A obesidade comum é atualmente um dos problemas de saúde pública mais importante no mundo, frequentemente associada a outros distúrbios tais como hipertensão, diabetes, doenças cardiovasculares e câncer. Apesar da alta prevalência de obesidade em diversas populações, muitos dos estudos relacionados aos seus fatores de risco genéticos foram realizados com indivíduos de ascendência europeia ou asiática, mas foram poucos os realizados com populações de origem africana ou nativas americanas. Nosso trabalho tem por objetivo geral investigar potenciais fatores de risco genéticos associados ao sobrepeso e à obesidade em populações afrodescendentes remanescentes de quilombos do Vale do Ribeira - SP, comunidades rurais semi-isoladas, previamente bem caracterizadas do ponto de vista clínico, genealógico e genético-populacional. Nossa amostra constituiu-se de 759 indivíduos, pertencentes a doze populações de remanescentes de quilombos (Abobral, São Pedro, Galvão, Ivaporunduva, Pedro Cubas, André Lopes, Nhunguara, Sapatu, Pilões, Maria Rosa, Poça e Reginaldo), dos quais foram obtidos amostras de DNA, dados clínicos, informações genealógicas e medidas antropométricas. A investigação dos fatores de risco genéticos associados ao sobrepeso/obesidade foi realizada por duas abordagens: (1) estudo de associação baseado em famílias (N = 584, 59 famílias) e (2) estudo de associação populacional com indivíduos não aparentados (N=305). Foram selecionados para estudo nove polimorfismos em oito genes candidatos: LEP rs2167270, LEPR rs1137101, ADRB2 rs1042713, PPARG rs1801282, PLIN1 rs2289487, RETN rs1862513, INSIG2 rs7566605, FTO rs1121980 e FTO rs1421085. As análises de associação baseadas em família indicaram que, nessas populações, apenas o polimorfismo PLIN1 rs2289487 está associado significativamente com o grupo de risco em relação à razão cintura-quadril (RCQ >=0,85 para mulheres e >=0,90 para homens; P=0,013). Aparentemente não existem trabalhos anteriores que verificaram a associação deste polimorfismo com a obesidade por essa metodologia. As análises do estudo populacional com indivíduos não aparentados mostraram associação significativa entre: (i) o alelo G no polimorfismo LEPR rs1137101 e a variação do índice de massa corporal (IMC; P=0,027); (ii) o alelo G do polimorfismo LEPR rs1137101 e o fenótipo de sobrepeso/obesidade (IMC>=25 Kg/m²; P=0,027); (iii) o alelo G no polimorfismo ADRB2 rs1042713 e o fenótipo de risco (IMC>=25 Kg/m²; P=0,029); (iv) o polimorfismo PLIN1 rs2289487 (genótipo GG) e os menores valores do IMC (P=0,025); (v) o polimorfismo FTO rs1121980 (alelo G) e o fenótipo de risco (IMC>=25 Kg/m²), assim como a variação do IMC (P=0,037 e P=0,022 respectivamente); e (vi) o alelo A no polimorfismo FTO rs1421085 e maiores valores da circunferência da cintura (Cc; P=0,016) e da razão cintura-quadril (RCQ; P=0,030). Tomados em conjunto, nossos resultados sugerem a participação dos genes LEP, LEPR, ADRB2, PLIN1 e FTO no aumento da predisposição ao sobrepeso e à obesidade nas populações remanescentes de quilombos. Por fim, as elevadas estimativas de herdabilidade dos três fenótipos investigados (IMC=33%, Cc=33% e RCQ=70%) reforçam a relevância do papel dos fatores genéticos no acúmulo de gordura corporal. O trabalho apresentado é resultado de uma investigação cuidadosa sobre os componentes genéticos associados à regulação do peso corporal em uma população brasileira afrodescendente (com características históricas, ambientais e genéticas peculiares), corroborando a hipótese de que a obesidade comum nas populações quilombolas do Vale do Ribeira é condicionada por um mecanismo poligênico modulado por fatores ambientais importantes como o sedentarismo e a transição nutricional

Performed acculturation at Fort Marion : a case study of Zotom's drawings

This study examines how Native American warriors imprisoned at Fort Marion in St. Augustine, Florida, between 1875 and 1878, used their drawings to perform acculturation. I use the Kiowa warrior Paul Caryl Zotom’s drawings as a case study to demonstrate how the prisoners became methodical and formulaic in their subject matter and artistic style. Euro-American visitors to Fort Marion appreciated particular drawings over others, thereby directing subject matter. Prisoners adopted European artistic standards, thus, connected with their White audience further. Zotom’s embrace of both the subject matter and artistic style that the Euro-American audience appreciated most indicates his desire to demonstrate how successful he and his fellow prisoners were at adopting the white man’s road. I argue that much of the apparent change displayed visually in Zotom’s drawings was performed rather than true acculturation.

Records of the Debating Club of Resident Graduates, 1792-1793

This journal contains minutes from meetings held from February 1792 through October 1793. These minutes include the names of participants and the questions and arguments which were debated, including: whether or not French slaves in the West Indies should be emancipated; whether or not reading novels was beneficial; whether sermons were more effective when memorized than when simply read; whether theater contributed to corrupt morals; whether drunkenness or gambling was more detrimental to society; and whether or not French assistance to the colonies in their Revolutionary War provided sufficient cause for the United States to join with France in its own wars. Most of the topics of debate centered on religion, government and education. Several entries also include notes on related topics of discussion, including the reasons for Native American tribes' hostilities against federal authorities, and there are several references to published works which were cited and consulted in the course of debate.

Odell, Richard, 2 autographed letters signed to John Winthrop; Southampton, Long Island, 1652 November 16-1653

Correspondence concerning an illness, which Odell believed was palsy or the King's evil (scrofula), that afflicted his five-year-old daughter. Odell writes that her symptoms included loss of speech and feeling in her right side, and a throat blockage, and he requests advice from Winthrop on the course of treatment the family should pursue. Odell writes again in 1653 thanking Winthrop for the ointment and electuary he had prescribed for the child. Her symptoms had persisted, however, and he requested further advice. Odell adds several lines regarding rumors of an insurrection of a Native American tribe, inquiring if Winthrop has any information regarding "how matters stand & between the Dutch & the English."

New England and Middle Atlantic States, 1671 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Novi Belgii, quod nunc Novi Jorck vocatur, Novae q[ue] Angliae & partis Virginiae : accuratissima et novissima delineatio. It was published by J. Meurs for Arnoldus Montanus' De Nieuwe en onbekende weereld, 1671. p. 122-123. Scale [ca. 1:3,500,000]. Covers the northeast Atlantic States from Maine to Virginia, and a portion of Canada. In Latin. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Mercator (world) projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as human settlements, Native American tribal lands, drainage, shoreline features, and more. Relief is shown pictorially. Includes illustrations and illustrative cartouche. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

New England and Middle Atlantic States, 1660 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Belgii novi, angliae novae, et partis Virginiae : novissima delineatio. It was published by Ioannes Ianssonius (Jan Jansson) between 1660 and 1663. Scale [ca. 1:2,450,000]. Covers the northeast Atlantic States from Maine to Virginia, and a portion of Canada. In Latin. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Mercator (world) projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as human settlements, forts, Native American tribal lands, drainage, shoreline features, and more. Relief is shown pictorially. Includes illustrations. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

New England and Middle Atlantic States, ca. 1684 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Novi Belgii Novaeque Angliae nec non partis Virginiae tabula : multis in locis emendata, per Nicolaum Visscher. It was published by N. Visscher ca. 1684. Scale [ca. 1:2,250,000]. Covers the northeast Atlantic States from Maine to Virginia, and a portion of Canada. In Latin and Dutch. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Mercator (world) projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as human settlements, forts, Native American tribal lands, drainage, territorial boundaries, shoreline features, and more. Relief is shown pictorially. Includes decorative cartouche and inset view of Manhattan: Nieuw Amsterdam op t eylant Manhattans. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

New England and Middle Atlantic States, ca. 1730 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Recens edita totius Novi Belgii in America Septentrionali siti, delineatio cura et sumtibus Matthaei Seutteri (Matthaeus Seutter). It was published ca. 1730. Scale [ca. 1:2,250,000]. Covers the northeast Atlantic States from Maine to Virginia, and a portion of Canada. In Latin. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Mercator (world) projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as human settlements, forts, Native American tribal lands, drainage, territory boundaries, shoreline features, and more. Relief is shown pictorially. Includes illustrations, illustrative cartouche, and inset view of Manhattan: Neu Jorck sive Neu Amsterdam. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

New England and Middle Atlantic States, ca. 1690 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Belgii novi, angliae novae, et partis Virginiae : novissima delineatio. It was published by Petrum Schenk and Gerardum Valk, ca. 1690. Scale [ca. 1:2,450,000]. Covers the northeast Atlantic States from Maine to Virginia, and a portion of Canada. In Latin. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Mercator (world) projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as human settlements, forts, Native American tribal lands, drainage, territory boundaries, shoreline features, and more. Relief is shown pictorially. Includes illustrations and decorative cartouches. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Old Northwest and Great Lakes Region, 1785 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: A map of the north west parts of the United States of America, [by] John Fitch. It was published in 1785. Scale [ca. 1:3,000,000]. Covers the Old Northwest from the Great Lakes to Kentucky and the Mississippi River to the Allegany River and a portion of Lake Ontario. The image inside the map neatline is georeferenced to the surface of the earth and fit to the USA Contiguous Albers Equal Area Conic projection (Meters). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as human settlements, forts, Native American lands, roads, drainage, proposed state boundaries, and more. Relief shown by landform drawing. Includes descriptive notes. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Nantucket, Massachusetts, 1869 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Historical map of Nantucket, surveyed and drawn by the Rev. F.C. Ever, D.D. It was published by The Major & Knapp Eng. Mfg. & Lith. Co. in 1869. Scale [1:26,720]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, drainage, Native American village and burial ground sites, historic sites, and more. It indicates boundaries of surveyed sections and of the Ancient Sachem Rights. Relief is shown by hachures. Includes historical notes and lists of historical dates and events for the seventeenth, eighteenth, and nineteenth centuries; latest date, 1865. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Brief Communication : Cranial Nonmetric Trait Database on the Internet

This brief note announces the publication of a nonmetric cranial trait database as a freely available resource on the Internet at: http://library.queensu.ca/web- doc/ssdc/cntd. The files were constructed in the program Excel, and are available also in comma-delimited format. These one-observer data on 38 traits were recorded in 1963–2003 in skeletal collections curated at many muse- ums. The 8,016 crania represent individuals from a broad geographic and temporal range of recent human popula- tions, with regions best represented being the Arctic and northwestern North America. Am J Phys Anthropol 152:551–553, 2013.

The life of General Ely S. Parker, last grand sachem of the Iroquois and General Grant's military secretary,

The Measure of the Man -- The Valley of the Rapid Water -- How the Senecas Made War Upon Great Britain -- The Grand-Daughter of the Prophet -- Boyhood Days on the Reservatio -- The Way the Twig Was Bent -- Lewis H. Morgan and the "New League of the Iroquois" -- Early Experience as an Engineer and Masonic Career -- How Parker's Enlistment was Refused by Secretary Seward -- A Sachem Becomes a Warrior -- The Fall of the Confederacy -- The Indian in the Drama at Appomattox -- The Warrior After the War -- An Indian Commissioner of Indian Affairs -- A Sachem's Letters to a Poetess -- The Gettysburg Speech of Grant's Military Secretary -- The House of Brother Nicholson -- The Bones of Red Jacket -- The Last Grand Sachem.