Distance from shore positively influences alert distance in three wetland bird species

Behavioural responses of wetland fauna to humans constitutes a potential conservation threat, and may alter how animals use wetlands and their surrounds. We predicted that the farther from refuge (i.e. water) that terrestrially foraging rails occurred, the longer the distance at which they would become alert when approached. We found that the distance at which Eurasian Coot, Fulica atra, Purple Swamphen, Porphyrio porphyrio, and Dusky Moorhen, Gallinula tenebrosa became alert to an approaching predator (i.e. human) increased with distance from the shore of a wetland (species and starting distance were not significant but associated with low power). Thus, these behavioural measures suggest these birds use water in wetlands as a refuge from potential threats such as people. © 2014 Springer Science+Business Media Dordrecht.

Interferência de educadores de camada média em educação popular

Pela educaçio o homem se apropria do mundo atra vês do exercício processual e consciente do saber e dopoder sobre a realidade e o mundo, realizando-se como sujeito da história em cuja construção se reconhece ao reconhecer sua participação como açio criadora. A divisão da sociedade em classes antagônicas fundamenta a possibilidade e a necessidade de uma proposta de Educação Popular como a forma de retomada pela classe dominada de um direito que lhe foi alienado, que e a Educa ção sem adjetivo, onde saber e poder são qualificados a partir do ser homem e nio a partir da posição que se ocupa em uma sociedade capitalista. A proposta de educação popular, para ter significincia, tem que objetivar a mudança social atrav~s da ne gação de estrutura de poder, assumida numa perspectiva de superação de suas contradições constituídas pela existência de classes antagônicas na sociedade. O sujeito dessa mudança social e a classe dominada que, atraves de grupos:populares organizados, assumem o processo educativo como instrumento de realização de seu projeto de libertaçio, em contraposição ao projeto da classe dominante que usa o sistema educativo-vigente, como for ma de manutenção do status quo ,de dominação. A interferência em educação popular da parte de pessoas de camadas media, que nao pertencem sociologicamen te ã classe dominada, põe problemas serios de viabilidade e eficácia. No entanto, com base em dados experimentais e teóricos, pode-se afirmar que essa interferência e válida e eficaz, mesmo que os educadores nao se integrem em forma de pertença ã classe dominada.Para a eficácia de sua interferência no processo educativo popular, os .educadores de camada media têm que manter na praxis educativa uma constante vigilância para se pôr a serviço da classe dominada e dominante. nao da classe As condições principais para esse intento sao: opçao pela mudança social, convicção consciente de que nao são eles, mas os educandos, os agentes principais da dita mudança e, consequentemente, o empenho na consecuçao, por parte dos educadores, de uma autintica autonomia no saber e no poder. Da interferência posta corretamente em prática sao também beneficiados esses mesmos educadores que, na sua praxis educativa, têm oportunidade de crescer na refor mulação de seu saber, tanto sobre a sociedade como sobre o seu posicionamento concreto diante das exigincias de mudança de uma sociedade cuja organização negaram na base de seu engajamento educativo.

Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum

Nutritional status is an important determinant to the response against Leishmania infection, although few studies have characterized the molecular basis for the association found between malnutrition and the disease. Vitamin A supplementation has long been used in developing countries to prevent mortality by diarrheal and respiratory diseases, but there are no studies on the role of vitamin A in Leishmania infection, although we and others have found vitamin A deficiency in visceral Leishmaniasis (VL). Regulatory T cells are induced in vitro by vitamin A metabolites and are considered important cells implicated T CD4+ cell suppression in human VL. This work aimed to examine the correlation of nutritional status and the effect of vitamin A in the response against Leishmania infantum infection. A total of 179 children were studied: 31 had active VL, 33 VL history, 44 were DTH+ and 71 were DTH- and had negative antibody to Leishmania (DTH-/Ac-). Peripheral blood monuclear cells were isolated in a subgroup of 10 active VL and 16 DTH-/Ac- children and cultivated for 20h under 5 different conditions: 1) Medium, 2) Soluble promastigote L. infantum antigens (SLA), 3) All-trans retinoic acid (ATRA), 4) SLA + ATRA and 5) Concanavalin A. T CD4+CD25highFoxp3+, T CD4+CD25-Foxp3- and CD14+ monocytes were stained and studied by flow cytometry for IL-10, TGF-β and IL-17 production. Nutritional status was compromised in VL children, which presented lower BMI/Age and retinol concentrations when compared to healthy controls. We found a negative correlation between nutritional status (measured by BMI/Age and serum retinol) and anti-Leishmania antibodies and acute phase proteins. There was no correlation between nutritional status and parasite load. ATRA presented a dual effect in Treg cells and monocytes: In healthy children (DTH-/Ac-), it induced a regulatory response, increasing IL-10 and TGF-β production; in VL children it modulated the immune response, preventing increased IL-10 production after SLA stimulation. Furthermore, we found a positive correlation between BMI/Age and IL-17 production and negative correlation between serum retinol and IL-10 and TGF-β production in T CD4+CD25highFoxp3+ cells after SLA stimulus. Our results show a potential dual role of vitamin A in the immune system: improvement of regulatory profile during homeostasis and down modulation of IL-10 in Treg cells and monocytes during symptomatic VL. Therefore, the use of vitamin A concomitant to VL therapy might improve recovery from disease status in Leishmania infantum infection

Abdominal hyperalgesia in secretory phospholipase A(2)-induced rat pancreatitis: Distinct roles of NK1 receptors

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Inhibition of Neurotoxic Secretory Phospholipases A(2) Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Adjuvantes e herbicidas e a infectividade de Fusarium graminearum, agente potencial de biocontrole de Egeria densa e Egeria najas

Foram estudados os efeitos da adição de adjuvantes e a associação com herbicidas na infectividade do fungo dentro do patossistema Fusarium graminearum x Egeria spp. Foram utilizadas plantas sadias de Egeria densa e E. najas inoculadas com uma suspensão de arroz moído colonizado por F. graminearum, na concentração de 0,7 g L-1. Os tubos de ensaio contendo as plantas imersas na referida suspensão foram mantidos em incubadora à temperatura de 25 ºC e fotoperíodo de 12 horas diárias de luz, por oito dias, durante os quais foram avaliados os sintomas nas plantas a cada dois dias e o crescimento destas através do incremento de matéria fresca ao final do experimento. O efeito de 14 adjuvantes e 6 herbicidas, adicionados à suspensão de inóculo, sobre a ação de F. graminearum em E. densa e E. najas foi avaliado. de modo geral, os adjuvantes melhoraram a eficiência do bioerbicida e a associação herbicida + fungo proporcionou maior severidade de doença e controle do crescimento das plantas.

cDNA sequence and molecular modeling of a nerve growth factor from Bothrops jararacussu venomous gland

The complete nucleotide sequence of a nerve growth factor precursor from Bothrops jararacussu snake (Bj-NGF) was determined by DNA sequencing of a clone from cDNA library prepared from the poly(A) + RNA of the venom gland of B.jararacussu. cDNA encoding Bj-NGF precursor contained 723 bp in length, which encoded a prepro-NGF molecule with 241 amino acid residues. The mature Bj-NGF molecule was composed of I 18 amino acid residues with theoretical pI and molecular weight of 8.31 and 13,537, respectively. Its amino acid sequence showed 97%, 96%, 93%, 86%, 78%, 74%, 76%, 76% and 55% sequential similarities with NGFs from Crotalus durissus terrificus, Agkistrodon halys pallas, Daboia (Vipera) russelli russelli, Bungarus multicinctus, Naja sp., mouse, human, bovine and cat, respectively. Phylogenetic analyses based on the amino acid sequences of 15 NGFs separate the Elapidae family (Naja and Bungarus) from those Crotalidae snakes (Bothrops, Crotalus and Agkistrodon). The three-dimensional structure of mature Bj-NGF was modeled based on the crystal structure of the human NGF. The model reveals that the core of NGF, formed by a pair of P-sheets, is highly conserved and the major mutations are both at the three beta-hairpin loops and at the reverse turn. (C) 2002 Societe francaise de biochimie et biologic moleculaire/Editions scientifiques et medicales Elsevier SAS. All rights reserved.

Influence of different doses of retinoic acid on cardiac remodeling

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Influence of acute pancreatitis on the in vitro responsiveness of rat mesenteric and pulmonary arteries

Background: Acute pancreatitis is an inflammatory disease characterized by local tissue injury and systemic inflammatory response leading to massive nitric oxide (NO) production and haemodynamic disturbances. Therefore, the aim of this work was to evaluate the vascular reactivity of pulmonary and mesenteric artery rings from rats submitted to experimental pancreatitis.Male Wistar rats were divided into three groups: saline (SAL); tauracholate (TAU) and phospholipase A(2) (PLA(2)). Pancreatitis was induced by administration of TAU or PLA(2) from Naja mocambique mocambique into the common bile duct of rats, and after 4 h of duct injection the animals were sacrificed. Concentration-response curves to acetylcholine (ACh), sodium nitroprusside (SNP) and phenylephrine (PHE) in isolated mesenteric and pulmonary arteries were obtained. Potency (pEC(50)) and maximal responses (E(MAX)) were determined. Blood samples were collected for biochemical analysis.Results: In mesenteric rings, the potency for ACh was significantly decreased from animals treated with TAU (about 4.2-fold) or PLA(2) (about 6.9-fold) compared to saline group without changes in the maximal responses. Neither pEC(50) nor E(MAX) values for Ach were altered in pulmonary rings in any group. Similarly, the pEC(50) and the E(MAX) values for SNP were not changed in both preparations in any group. The potency for PHE was significantly decreased in rat mesenteric and pulmonary rings from TAU group compared to SAL group (about 2.2- and 2.69-fold, for mesenteric and pulmonary rings, respectively). No changes were seen in the E(MAX) for PHE. The nitrite/nitrate (NO(x)(-)) levels were markedly increased in animals submitted to acute pancreatitis as compared to SAL group, approximately 76 and 68% in TAU and PLA(2) protocol, respectively.Conclusion: Acute pancreatitis provoked deleterious effects in endothelium-dependent relaxing response for ACh in mesenteric rings that were strongly associated with high plasma NO(x)(-) levels as consequence of intense inflammatory responses. Furthermore, the subsensitivity of contractile response to PHE in both mesenteric and pulmonary rings might be due to the complications of this pathological condition in the early stage of pancreatitis.

Chronic Ethanol Consumption Alters All-Trans-Retinoic Acid Concentration and Expression of Their Receptors on the Prostate: A Possible Link Between Alcoholism and Prostate Damage

Background: Ethanol (EtOH) alters the all-trans-retinoic acid (ATRA) levels in some tissues. Retinol and ATRA are essential for cell proliferation, differentiation, and maintenance of prostate homeostasis. It has been suggested that disturbances in retinol/ATRA concentration as well as in the expression of retinoic acid receptors (RARs) contribute to benign prostate hyperplasia and prostate cancer. This study aimed to evaluate whether EtOH consumption is able to alter retinol and ATRA levels in the plasma and prostate tissue as well as the expression of RARs, cell proliferation, and apoptosis index. Methods: All animals were divided into 4 groups (n = 10/group). UChA: rats fed 10% (v/v) EtOH ad libitum; UChACo: EtOH-naïve rats without access to EtOH; UChB: rats fed 10% (v/v) EtOH ad libitum; UChBCo: EtOH-naïve rats without access to EtOH. Animals were euthanized by decapitation after 60 days of EtOH consumption for high-performance liquid chromatography and light microscopy analysis. Results: EtOH reduced plasma retinol concentration in both UChA and UChB groups, while the retinol concentration was not significantly different in prostate tissue. Conversely, plasma and prostate ATRA levels increased in UChB group compared with controls, beyond the up-regulation of RARβ and -γ in dorsal prostate lobe. Additionally, no alteration was found in cell proliferation and apoptosis index involving dorsal and lateral prostate lobe. Conclusions: We conclude that EtOH alters the plasma retinol concentrations proportionally to the amount of EtOH consumed. Moreover, high EtOH consumption increases the concentration of ATRA in plasma/prostate tissue and especially induces the RARβ and RARγ in the dorsal prostate lobe. EtOH consumption and increased ATRA levels were not associated with cell proliferation and apoptosis in the prostate. © 2012 by the Research Society on Alcoholism.

Viagens ao 'outro lado': o percurso poético lecléziano

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Influência de diferentes doses de ácido retinóico na remodelação cardíaca

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O pop rock e a escritura poética em Voyages de l’Autre Côté, de Jean-Marie Gustave Le Clezio

A literatura contemporânea expressa o rompimento das fronteiras entre a cultura erudita e a cultura de massa ou comercial, criando formas híbridas que convivem no interior do texto. No romance Voyages de l’autre cote (1975), de Jean-Marie Gustave Le Clézio, as canções do pop rock embalam as viagens da fada Naja Naja e de seus amigos em busca do ‘outro lado’. Desta forma, a impregnação da música popular à escritura poética, parece ajudar a libertar a imaginação, preparando as personagens para o encontro do infinito sensível.

Inclusão das mulheres como investidoras na bolsa de valores de São Paulo: limites e ambiguidades

A educação financeira, tema constante de programas de TV de grande audiência, é analisada nesta obra como uma crença produzida pelo mundo das finanças, segundo a qual a financeirização é um processo que envolve valores morais, culturais, políticos, simbólicos e sociais presentes no mercado e que se configuram e se reconfiguram, colaborando assim para a transformação cognitiva da sociedade e do capitalismo contemporâneo. No Brasil o tema ganhou relevância durante o Governo Lula, com a criação da Estratégia Nacional de Educação Financeira, em 2007, e do Comitê Nacional de Educação Financeira, em 2010. As iniciativas foram seguidas pelo setor privado, com a instituição pela Bolsa de Valores de São Paulo, em 2011, do projeto Bovespa Vai Até Você, visando a democratização e popularização do mercado de capitais. É a partir desse programa, que a bolsa paulista institui o programa Mulheres em Ação, voltado para o público feminino. A autora observa que a criação de uma nova crença que esteja em consonância com o mundo das finanças é essencial para que o capitalismo se produza e se reproduza. E cita o sociólogo Roberto Grün: [...] o Brasil vive no início do século 21 a instauração de um modo de dominação financeiro. Mais que um simples money talks, estamos diante da dominação cultural das finanças, que impõem a proeminência das suas maneiras de enxergar a realidade brasileira e enquadrar os problemas do país. Tomando como base esse contexto, a autora realiza uma abordagem sociológica do tema, privilegiando as questões sociais, culturais e simbólicas pertinentes. Mais que analisar uma suposta mudança de hábitos das mulheres que procuram pelo curso de educação financeira da BM&FBovespa, o objetivo do estudo é enfatizar estratégias e mecanismos utilizados pela bolsa de valores para atraí-las. Entre estes, está o Mulheres em Ação, projeto que adota com...

Sustainable development in the BRICS countries: an efficiency analysis by data envelopment

There is much concern about the social and environmental impacts caused by the economic growth of nations. Thus, to evaluate the socio-economic performance of nations, economists have increasingly addressed matters related to social welfare and the environment. It is within the scope of this context that this work discusses the performance of countries in the BRICS group regarding sustainable development. The objective of this study regards evaluating the efficiency of these countries in transforming productive resources and technological innovation into sustainable development. The proposed objective was achieved by using econometric tools as well as the data envelopment analysis method to then create economic, environmental, and social efficiency rankings for the BRICS countries, which enabled to carry out comparative analyses on the sustainable development of those countries. The results of such assessments can be of interest for more specific scientific explorations.