Ms. Praed. 104 - De veritate catholicae fidei tractatus apologeticus

Vorbesitzer: Dominikanerkloster Frankfurt am Main

The Antimalarial Drug Proguanil Is An Antagonist at 5-HT3 Receptors

Proguanil is an antimalarial prodrug that is metabolized to 4-chlorophenyl-1-biguanide (CPB) and the active metabolite cycloguanil (CG). These compounds are structurally related to meta-chlorophenyl biguanide (mCPBG), a 5-hydroxytryptamine 3 (5-HT3) receptor agonist. Here we examine the effects of proguanil and its metabolites on the electrophysiology and ligand-binding properties of human 5-HT3A receptors expressed in Xenopus oocytes and human embryonic kidney 293 cells, respectively. 5-HT3 receptor responses were reversibly inhibited by proguanil, with an IC50 of 1.81 μM. Competitive antagonism was shown by a lack of voltage-dependence, Schild plot (Kb = 1.70 μM), and radioligand competition (Ki = 2.61 μM) with the 5-HT3 receptor antagonist [3H]granisetron. Kinetic measurements (kon = 4.0 × 104 M−1 s−1; koff = 0.23 s−1) were consistent with a simple bimolecular reaction scheme with a Kb of 4.35 μM. The metabolites CG and CPB similarly inhibited 5-HT3 receptors as assessed by IC50 (1.48 and 4.36 μM, respectively), Schild plot (Kb = 2.97 and 11.4 μM), and radioligand competition (Ki = 4.89 and 0.41 μM). At higher concentrations, CPB was a partial agonist (EC50 = 14.1 μM; I/Imax = 0.013). These results demonstrate that proguanil competitively inhibits 5-HT3 receptors, with an IC50 that exceeds whole-blood concentrations following its oral administration. They may therefore be responsible for the occasional gastrointestinal side effects, nausea, and vomiting reported following its use. Clinical development of related compounds should therefore consider effects at 5-HT3 receptors as an early indication of possible unwanted gastrointestinal side effects.

Ms. lat. oct. 104 - Speculum deiparae virginis Mariae

Vorbesitzer: Hilarion a S. Francisco

Isotope measurements from late Paleocene - early Eocene of 5 cores from Atlantic and Pacific Ocean

High-resolution stable carbon isotope records for upper Paleocene - lower Eocene sections at Ocean Drilling Program Sites 1051 and 690 and Deep Sea Drilling Project Sites 550 and 577 show numerous rapid (40 - 60 kyr duration) negative excursions of up to 1 per mill. We demonstrate that these transient decreases are the expected result of nonlinear insolation forcing of the carbon cycle in the context of a long carbon residence time. The transients occur at maxima in Earth's orbital eccentricity, which result in high-amplitude variations in insolation due to forcing by climatic precession. The construction of accurate orbital chronologies for geologic sections older than ~ 35 Ma relies on identifying a high-fidelity recorder of variations in Earth's orbital eccentricity. We use the carbon isotope records as such a recorder, establishing a robust orbitally tuned chronology for latest Paleocene-earliest Eocene events. Moreover, the transient decreases provide a means of precise correlation among the four sites that is independent of magnetostratigraphic and biostratigraphic data at the <10^5-year scale. While the eccentricity-controlled transient decreases bear some resemblance to the much larger-amplitude carbon isotope excursion (CIE) that marks the Paleocene/Eocene boundary, the latter event is found to occur near a minimum in the ~400-kyr eccentricity cycle. Thus the CIE occurred during a time of minimal variability in insolation, the dominant mechanism for forcing climate change on 104-year scales. We argue that this is inconsistent with mechanisms that rely on a threshold climate event to trigger the Paleocene/Eocene thermal maximum since any threshold would more likely be crossed during a period of high-amplitude climate variations.

Competencias del profesional de la información: un andén en el Mercosur. p. 99-104. En: Tercer Encuentro de Directores y Segundo de Docentes de las Escuelas de Bibliotecología del Mercosur: actas de los acuerdos, recomendaciones, conferencias y ponencias (28-30 oct. 1998).

Es este artículo se analizan las competencias intelectuales, prácticas y sociales que deberían desarrollar los profesionales de la información del Mercosur. Se definen las competencias, se fijan los límites del "Mercosur Informacional", se expresan los lineamientos teóricos de la "competencia" en la Argentina, para luego exponer sobre las competencias del profesional de las Ciencias de la Información, la necesidad de innovar en material de formación profesional para que este colectivo responda a las necesidades de este ámbito socioeconómico.

Procedimientos servianos de lectura acerca de los certámenes fúnebres en Eneida V : La naumaquia (vv. 104-285)

La figura de Servio y su comentario a la obra virgiliana constituye la summa opera de la tradición escolar tardoantigua; su importancia reside porque es el resultado de numerosas estratificaciones que recogen diversos abordajes exegéticos. Al tratarse de un comentario ?continuo?, los Commentarii servianos comprenden un conjunto de saberes que examinan la obra literaria desde la perspectiva histórica y de todo aquello que se relacionaba con esta. A partir de esta mirada lectora, la comunicación se centrará en el análisis que Servio realiza sobre la naumaquia del libro V de la Eneida (vv. 104-285), donde el texto base expone una secuencia narrativa caracterizada por epicismos homéricos y pos-homéricos que el gramático desarticula, privilegiando aspectos como el lingüístico, retórico, fabuloso y histórico-arqueológico. Asimismo, se comprobará que el certamen virgiliano constituye un pretexto para instalar un nuevo contexto que garantice la continuidad del sistema burocrático imperial

Reseña de: Ezcurra, A.M. (2011). Igualdad en Educación Superior : Un desafío mundial. Los Polvorines: Universidad Nacional de General Sarmiento - IEC/CONADU, 108 pp.

Fil: Marchese, Elisa. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.