Hydrochemistry measured on water bottle samples during the R/V Meteor cruise M96 (May, 2013) across the Tropical North Atlantic

The table includes hydrography (salinity, temperature, density, oxygen concentrations) and nutrient (nitrate, nitrite, ammonium, phosphate) measurements from surface waters (upper 200 m) across a 14 °N transect of the Tropical North Atlantic.

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.

AML1 is involved in the (8;21) translocation, associated with acute myelogenous leukemia (AML)-type M2, which results in the production of the AML1-ETO fusion protein: the amino-terminal 177 amino acids of AML1 and the carboxyl-terminal 575 amino acids of ETO. The mechanism by which AML1-ETO accomplishes leukemic transformation is unknown; however, AML1-ETO interferes with AML1 transactivation of such AML1 targets as the T-cell receptor beta enhancer and the granulocyte-macrophage colony-stimulating factor promoter. Herein, we explored the effect of AML1-ETO on regulation of a myeloid-specific AML1 target, the macrophage colony-stimulating factor (M-CSF) receptor promoter. We found that AML1-ETO and AML1 work synergistically to transactivate the M-CSF receptor promoter, thus exhibiting a different activity than previously described. Truncation mutants within the ETO portion of AML1-ETO revealed the region of ETO necessary for the cooperativity between AML1 and AML1-ETO lies between amino acids 347 and 540. Endogenous M-CSF receptor expression was examined in Kasumi-1 cells, derived from a patient with AML-M2 t(8;21) and the promonocytic cell line U937. Kasumi-1 cells exhibited a significantly higher level of M-CSF receptor expression than U937 cells. Bone marrow from patients with AML-M2 t(8;21) also exhibited a higher level of expression of M-CSF receptor compared with normal controls. The upregulation of M-CSF receptor expression by AML1-ETO may contribute to the development of a leukemic state in these patients.

Meeting minutes maintained by the Secretary, April 21, 1812; May 4, 1812; and June 3, 1812

These minutes pertain to discussions of the General Court's "act to repeal an act" (also called "the Act to alter and amend the Constitution of the Board of Overseers of Harvard College, and to regulate certain meetings of said Board") in February 1812, which repealed changes made in 1810 to the Constitution of the Board of Overseers. The Overseers present at these meetings doubted the act's legality and discussed ignoring and/or attempting to overturn the act.

Peabody's Petition, [1768 May]

One-page undated handwritten confession by Stephen Peabody to the Harvard Faculty.

Wm Howe & others Account and Receipt, 1768 May 21

Itemized handwritten bill for the services of eight men who guarded the College property on April 3, 1768. Includes a note by Deputy Sheriff William How[e] acknowledging receipt of payment by President Holyoke on May 21, 1768.

Address, 1789 May 21

Handwritten four-page draft of an address by Eliphalet Pearson. The address, made on behalf of the Harvard Corporation, relays the resolution of the Board of Overseers regarding the hours during which students should be in their chambers, restrictions on their ability to go into town, and emphasizing the College government's "fervent wish to see virtue & order prevalent among the students of this society." The introduction discusses the expectations of parents for their children to receive "a polite, virtuous, & religious education" instead of "sending him to a place, which is said to be noted for rudeness, vice, & irreligion."