Effects of (-)-cubebin (Piper cubeba) on cytotoxicity, mutagenicity and expression of p38 MAP kinase and GSTa2 in a hepatoma cell line

(-)-Cubebin is a lignan extracted from the seeds of the pepper Piper cubeba, a commonly eaten spice with beneficial properties, including trypanocidal, anti-inflammatory, analgesic, anti-proliferative and leishmanicidal activities. Because of its therapeutic potential, we investigated the effects of (-)-cubebin on the cytotoxicity, cell proliferation kinetics, mutagenicity and expression of p38 MAP kinase and glutathione S-transferase a2 (GSTa2) using real-time RT-PCR in Rattus norvegicus hepatoma cells. We found that 280 μM (-)-cubebin was cytotoxic after 24, 48 and 72. h of exposure, but not mutagenic at 0.28 μM, 2.8 μM and 28 μM after 26. h. Similarly, exposure to 0.28 μM, 2.8 μM and 28 μM (-)-cubebin for 24, 48, 72 and 96. h did not alter the cell proliferation kinetics. Cells exposed to 28 μM (-)-cubebin for 24. h did not exhibit changes in p38 MAP kinase and GSTa2 expression, indicating that cellular changes were not induced by extracellular stimuli and that (-)-cubebin is likely not metabolized via this pathway. Our results suggest that high levels of (-)-cubebin should be consumed with caution due to the cytotoxic effect observed at the highest concentration. However, at lower concentrations, no cytotoxic, mutagenic or proliferative effects were observed, providing further evidence of the safety of consuming (-)-cubebin. © 2013 Elsevier Inc.

Gestão da informação no jornalismo on-line: estudo do portal Campo Grande News

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Corpos modernos e vigorexia na rede social virtual: ideais midiáticos e suas influências na imagem corporal masculina

Pós-graduação em Desenvolvimento Humano e Tecnologias - IBRC

Rede social e papéis de gênero de casais ribeirinhos de uma comunidade amazônica

Este estudo descreve as redes sociais de dois casais de uma comunidade ribeirinha (Rio Araraiana, Município de Ponta de Pedras, Ilha do Marajó/Pará). Os dados foram coletados com um inventário sócio-demográfico, um inventário de rotina e diários de campo e, analisados pelo mapa de rede de Sluzki. Constatou-se que os vínculos dos casais são baseados em alianças de ajuda econômica e de trabalho, companhia para lazer ou atividade religiosa. Verificou-se que as relações são marcadas por padrões de gênero que delimitam os ambientes das atividades cotidianas, definem o status ocupado na família e condicionam a formação de vínculos na rede social.

Preferência estética do perfil facial avaliado on-line por brasileiros

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Investigação da colaboração científica na temática de indexação em periódicos on-line em âmbito nacional

This research seeks to demonstrate the scientific collaboration in the field of Information Science, specifically in the thematic indexing, by analyzing the co-authors network, based on scientific collaboration in Brazilian journals online, according to CAPES. We selected six Brazilian journals online, namely: Ciência da Informação; Transinformação; Perspectivas da Ciência da Informação; Encontros BIBLI: Revista Eletrônica de Biblioteconomia e Ciência da Informação; DataGramaZero and Em Questão, totaling 25 articles. It was built in coauthorship network, using Pajek software in order to evaluate interactions between researchers and cohesion of the network by calculating its density.

Boca a boca on-line: um estudo sobre a Gestão da Comunicação na Internet

Researchs about consumer behavior show influences coming from a lot of fonts. Among them culture, social class, personal influence, family and consumer situation. Personal influence it’s the font object of this research. Personal influence can define what a consumer will buy or will not buy, especially with closer friends. Normally people got the information and transmit to him group, him family, making some difference in the opinion of this people. Ten years ago we were i………..by a dozen of friends. In these days, we have more facility to communicate and more facility to receiver information trough internet. Our personal influence extended from our closest friend to the world wide web group. That’s why company’s must to know what the consumer is speaking on internet

Abordagem técnica sobre os aspectos de uma rede social colaborativa

With the advancement of the gaming industry in the market, became evident the need for professionals working in this area. With this in mind, this paper attempts to create an environment where aspirants and professionals in creating games can interact. To get to this point, was built one system based on current technologies, and parad igms of software engineering system. So throughout this monograph the process of the system development is studied, using different technologies, and showing how it can work, the exchange of information and knowledge among the games creation lovers

Planejamento e prototipagem de uma rede social de gastronomia convergente com programas de TV e mídias sociais

Pós-graduação em Televisão Digital: Informação e Conhecimento - FAAC

A simple high-performance liquid chromatography assay for on-line determination of catecholamines in adrenal gland by direct injection on an ISRP column

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Gênero, cultura e rede social: a construção social da desigualdade de gênero por meio da linguagem

Based on systemic-cybernetic-new paradigm vision and social constructionism, the paper is an invitation to reflect on the importance of language in the maintenance and the possibility of changing unequal relational patterns, mainly related to issues of gender. Studies on language and verbal behavior of women and men, besides their representation in the media, are examples to illustrate the need advocated here, to changing patterns of inequality guided by gender differences that influence and are influenced by the culture, conveyed in our social network. This paper is a contribution for the clinical work with families and couples, from the perspective of the current behaviors, based on refrains spread by the media which became popular, since it is based on clinical and nonclinical observations about human relationships and its representation in the media and artistic productions.

Levante popular da juventude brasileira: saímos do Facebook (on line)

The paper studies the mobilization occurred in June 2013 in Brazil, initially under the banner of the Movement Free Pass, but without the existence of a lead, but multiple voices that alternate in search of social and economic change. The object of study is the communication made through social networks and their realization, or realization, the streets of major cities. The rallies demonstrate the power of communications media and a new phenomenon of talk, the use of social networks, now as uniting factor and not just a showcase of everyday life. The internet has become a new means of communication easy and free access, in addition to its fast dissipation data. Thus, the youth was used such technology to an uprising in the pursuit of social improvement of the cities where marches happened. Such a move still without an academic and social needs to be discussed so that, in addition to understood, can expand contributions to society, helping it in its claims. Was chosen as the site for the #causabrasil study and understanding of issues in which the public expresses dissatisfaction. The site performs an analysis with the combination of hastags a list of pre-registered and a list of terms used by different users of Facebook, Twitter, Instagram, Youtube and Google, through monitoring tool Seekr, and an infographic presents the main political demands of the population.

PROFIX: método de avaliação on-line da proficiência digital

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)