Ocean acidification alters the material properties of Mytilus edulis shells

Ocean acidification (OA) and the resultant changing carbonate saturation states is threatening the formation of calcium carbonate shells and exoskeletons of marine organisms. The production of biominerals in such organisms relies on the availability of carbonate and the ability of the organism to biomineralize in changing environments. To understand how biomineralizers will respond to OA the common blue mussel, Mytilus edulis, was cultured at projected levels of pCO2 (380, 550, 750, 1000 µatm) and increased temperatures (ambient, ambient plus 2°C). Nanoindentation (a single mussel shell) and microhardness testing were used to assess the material properties of the shells. Young's modulus (E), hardness (H) and toughness (KIC) were measured in mussel shells grown in multiple stressor conditions. OA caused mussels to produce shell calcite that is stiffer (higher modulus of elasticity) and harder than shells grown in control conditions. The outer shell (calcite) is more brittle in OA conditions while the inner shell (aragonite) is softer and less stiff in shells grown under OA conditions. Combining increasing ocean pCO2 and temperatures as projected for future global ocean appears to reduce the impact of increasing pCO2 on the material properties of the mussel shell. OA may cause changes in shell material properties that could prove problematic under predation scenarios for the mussels; however, this may be partially mitigated by increasing temperature.

Contemporary eden: the transmigration of paradise tales, into edenic architectures today

This document proceeds from the research for my doctoral thesis titled This thesis is about the subject of Eden or paradise in architecture, to understand its concepts and be able to generate a general model to generate architecture that places us in a virtual way in paradisiacal places, in holidays as well as in daily life. It also seeks to build a system of measure to be used to turn into Eden the previously non “Edenic”. A comparative measuring system to know where we are in relation to how much Eden is present in places to intervene, or project. Eden; Tale, Image and Project. The zones of the thesis that are related to this congress are those related to the use of this tale, idea and image of the collective unconscious, when it comes to projecting a place that locates us physically, mentally and in our mood in paradise.

Specific therapy regimes could lead to long-term immunological control of HIV

We use mathematical models to study the relationship between HIV and the immune system during the natural course of infection and in the context of different antiviral treatment regimes. The models suggest that an efficient cytotoxic T lymphocyte (CTL) memory response is required to control the virus. We define CTL memory as long-term persistence of CTL precursors in the absence of antigen. Infection and depletion of CD4+ T helper cells interfere with CTL memory generation, resulting in persistent viral replication and disease progression. We find that antiviral drug therapy during primary infection can enable the development of CTL memory. In chronically infected patients, specific treatment schedules, either including deliberate drug holidays or antigenic boosts of the immune system, can lead to a re-establishment of CTL memory. Whether such treatment regimes would lead to long-term immunologic control deserves investigation under carefully controlled conditions.

Analysing three basic decisions of tourists: going away, going abroad and going on tour

This study analyses determinant factors in the taking of three basic decisions on the part of holidaymakers: going on holiday, foreign holidays and multi-destination holidays. We propose various research hypotheses relating to the impact on these decisions of various personal characteristics. The methodology used estimates various Binomial Logit models. The empirical application carried out in Spain on a sample of 3,781 individuals allows us to conclude that personal characteristics related to the chosen destination, personal restrictions and socio-demographic and psychographic characteristics are determinants of these decisions.

Diary of Thomas Marsh, 1751

Diary kept in an interleaved almanac from 1751. Entries in the diary are brief and sporadic, recording events including travel, visitors, weather, sermons heard, holidays, illnesses and deaths. Occasional expenses are noted, including ones for hay, cider, bottles, shoes, and doctoring. A few dates of college events are noted, including the semi-annual Corporation meeting and Commencement. On the last page is a list of student names, presumably those tutored by Marsh.

Where to spend the holidays : favourite resorts in North & Central Wales, the English Lake District, Scotland & Ireland.

Includes index.

Holidays in Wales.

"350 copies have been set aside by the publisher as Keepsake no. 29 for distribution by the Typophiles."