Amyotrophic lateral sclerosis and Parkinsonism-dementia complex of Guam: Descriptive epidemiology, secular trends, and birth cohort effects on incidence, 1950--1989

This study describes the patterns of occurrence of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) of Guam during 1950-1989. Both ALS and PDC occur with high frequency among the indigenous Chamorro population, first recognized in the early 1950's. Reports in the early 1980's indicated that both ALS and PDC were disappearing, due to a purported reduction in exposure to harmful environmental factors as a result of the dramatic changes in lifestyle that took place after World War II. However, this study provides compelling evidence that ALS and PDC have not disappeared on Guam and that rates for both are higher during 1980-1989 than previously reported.^ The patterns of occurrence for both ALS and PDC overlap in most respects: (1) incidence and mortality are decreasing; (2) median age at onset is increasing; (3) males are at increased risk for developing disease; (4) risk is higher for those residing in the south compared to the non-south; and (5) age-specific incidence is decreasing over time except in the oldest age groups.^ Age-specific incidence of ALS and PDC, separately and together, is generally higher for cohorts born before 1920 than for those born after 1920. A significant birth cohort effect on the incidence of PDC for the 1906-1915 birth cohort was found, but not for ALS and for ALS and PDC together. Whether or not a cohort effect, period effect, or both are associated with incidence of ALS and PDC cannot be determined from the data currently available and will require additional follow-up of individuals born after 1920.^ The epidemiological data amassed over this 40-year period provide evidence that supports an environmental exposure model for disease occurrence as opposed to a simple genetic or infectious disease model. Whether neurodegenerative disease in this population occurs as a consequence of a single exposure or is explained by a multifactorial model such as a genetic predisposition with some environmental interaction is yet to be determined. However, descriptive studies such as this can provide clues concerning timing and location of potential adverse exposures but cannot determine etiology, underscoring the urgent need for analytic studies of ALS and PDC to further investigate existing etiologic hypotheses and to test new hypotheses. ^

Pancreatic cancer deaths in Texas veterans

Background/objective. Several studies have found an increased risk of pancreatic cancer in veterans deployed to Vietnam during the Vietnam War. Diabetes, a known risk factor for pancreatic cancer, has been designated as a service-connected illness in deployed Vietnam veterans. The majority of Vietnam veterans, now between the ages of 55 to 65, have not yet reached the ages of pancreatic cancer’s greatest prevalence, ages 65 to 79. This case-control study utilized 1998 electronic Texas death certificate data for white, black and Hispanic men to explore the question of whether military service was a risk factor for deaths due to pancreatic cancer among men who died in 1998.^ Methods. The primary study included men born between 1927 and 1953, and was a matched case-control study with two control groups; 431 pancreatic cancer cases were birth-year and race-matched one case to two non-neoplastic death controls and, for the second control group, were matched 1:1 with 431 accidental death controls. The exposure was military service, recorded as “yes”, “no” or “unknown” on the death certificate. Conditional logistic regression was used for the data analysis. Logistic regression was used in two additional unmatched analyses to examine the same exposure, military service, within different birth cohorts, again using pancreatic cancer cases with non-neoplastic and accidental death controls.^ Results. For pancreatic cancer cases matched to non-neoplastic controls, the association with military service showed an elevated odds ratio (OR) of 1.40 (95% confidence interval [CI] 1.10-1.79); matched to accidental death controls, a similar association with military service was detected [OR=1.40 (95% CI 1.04-1.89)]. The association was not seen in all time periods and was greatest for those within a birth cohort specific for Vietnam Era service. For men born between 1946 and 1950, OR=1.90 (95% CI 1.03-3.50) for comparison with non-neoplastic controls and OR=1.91 (95% CI 0.9995-3.64) for accidental death controls. ^ Conclusion. In Texas, for men aged 44-71, who died in 1998, military service was associated with an approximately 40% increased risk for pancreatic cancer. For men ages 48-52, military service was associated with an approximately 90% increased risk for pancreatic cancer.^

Sea ice limit in the Southern Ocean 1950/51

Die zwei Südwinter und einen Südsommer umspannende Expedition erbrachte so umfangreiche Ergebnisse, daß mit deren Veröffentlichung erst in Jahren gerechnet werden kann. Aus der Fülle der Beobachtungen und Messungen seien herausgegriffen: der wechselnde Verlauf der Packeisgrenze der Antarktis.

Intelectuales y Guerra Fría : El Congreso por la Libertad de la Cultura en Argentina y Chile, 1950-1964

El artículo compara la trayectoria de las filiales argentina y chilena del Congreso por la Libertad de la Cultura - un producto de Estados Unidos en la Guerra Fría cultural creado en 1950-entre 1950 y 1964. Basado en numerosas fuentes primarias y secundarias, contribuye a de-centrar los estudios sobre la Guerra Fría cultural, mostrando la manera en que desarrollos históricos internacionales fueron procesados a nivel local y revelando similitudes y diferencias entre las dos filiales relacionadas con el contexto político, ideológico y cultural específico de cada país.

Intelectuales y Guerra Fría : el Congreso por la Libertad de la Cultura en Argentina y Chile, 1950-1964

El artículo compara la trayectoria de las filiales argentina y chilena del Congreso por la Libertad de la Cultura - un producto de Estados Unidos en la Guerra Fría cultural creado en 1950-entre 1950 y 1964. Basado en numerosas fuentes primarias y secundarias, contribuye a de-centrar los estudios sobre la Guerra Fría cultural, mostrando la manera en que desarrollos históricos internacionales fueron procesados a nivel local y revelando similitudes y diferencias entre las dos filiales relacionadas con el contexto político, ideológico y cultural específico de cada país.

Intelectuales y Guerra Fría : El Congreso por la Libertad de la Cultura en Argentina y Chile, 1950-1964

El artículo compara la trayectoria de las filiales argentina y chilena del Congreso por la Libertad de la Cultura - un producto de Estados Unidos en la Guerra Fría cultural creado en 1950-entre 1950 y 1964. Basado en numerosas fuentes primarias y secundarias, contribuye a de-centrar los estudios sobre la Guerra Fría cultural, mostrando la manera en que desarrollos históricos internacionales fueron procesados a nivel local y revelando similitudes y diferencias entre las dos filiales relacionadas con el contexto político, ideológico y cultural específico de cada país.

Intelectuales y Guerra Fría : El Congreso por la Libertad de la Cultura en Argentina y Chile, 1950-1964

El artículo compara la trayectoria de las filiales argentina y chilena del Congreso por la Libertad de la Cultura - un producto de Estados Unidos en la Guerra Fría cultural creado en 1950-entre 1950 y 1964. Basado en numerosas fuentes primarias y secundarias, contribuye a de-centrar los estudios sobre la Guerra Fría cultural, mostrando la manera en que desarrollos históricos internacionales fueron procesados a nivel local y revelando similitudes y diferencias entre las dos filiales relacionadas con el contexto político, ideológico y cultural específico de cada país.