The works of Oliver Goldsmith, M.B. : with a life and notes /

Mode of access: Internet.

The Strank Munro letters: being a series of twelve letters written by J. Stark Munro, M. B., to his friend and former fellow-student, Herbert Swanborough ... during the years 1881-1884;

Mode of access: Internet.

The morning watches and night watches.

Mode of access: Internet.

S. Ephraim's prose refutations of Mani, Marcion, and Bardaisan, of which the greater part has been transcribed from the palimpsest B.M. add. 14623 and is now first published,

Title varies: v.2 ... Completed by A. A. Bevan and F. C. Burkitt.

Bibliotheca Wiffeniana. Spanish reformers of two centuries from 1520; their lives and writings, according to the late Benjamin B. Wiffen's plan and with the use of his materials.

Reprint of the 1874-1904 ed.

Operator, organizational and field (third echelon) maintenance repair parts and special tool lists and maintenance allocation chart, axles RL-27-B, RL-27-C, and RL-27-D.

"11 June 1964."

University of Michigan President Harry B. Hutchins with faculty and regents at Camp Douglas

front row left to right: Walter Sawyer, Harry B. Hutchins, Junius C. Beal; behind Beal: C. E. Johnson, ? , Howard Merrick

Pompeiana: :b the topography, edifices and ornaments of Pompeii, the result of excavations since 1819.

Plate xiv, v. 1, colored.

International radiotelegraph convention : hearing before the Committee on Foreign Relations, United States Senate, Seventieth Congress, first session, on Executive B, International radiotelegraph convention, and general and supplementary regulations relating thereto. March 14, 1928.

William E. Borah, chairman.

Record. Kentucky, Kenton circuit court. Covington & Lexington railroad co., plaintiff, against in equity. James Winslow, trustee, etc., R.B. Bowler's heirs, and others, defendants.

Mode of access: Internet.

Sources and transport of surface sediment and metals in B.C. fjord, Tahsis and Zeballos Inlets

Senior thesis written for Oceanography 445

Heterodimers and family-B GPCRs:RAMPs, CGRP and adrenomedullin

RAMPs (receptor activity-modifying proteins) are single-pass transmembrane proteins that associate with certain family-B GPCRs (G-protein-coupled receptors). Specifically for the CT (calcitonin) receptor-like receptor and the CT receptor, this results in profound changes in ligand binding and receptor pharmacology, allowing the generation of six distinct receptors with preferences for CGRP (CT gene-related peptide) adrenomedullin, amylin and CT. There are three RAMPs: RAMP1-RAMP3. The N-terminus appears to be the main determinant of receptor pharmacology whereas the transmembrane domain contributes to association of the RAMP with the GPCR. The N-terminus of all members of the RAMP family probably contains two disulphide bonds; a potential third disulphide is found in RAMP1 and RAMP3. The N-terminus appears to be in close proximity to the ligand and plays a key role in its binding, either directly or indirectly. BIBN4096BS, a CGRP antagonist, targets RAMP1 and this gives the compound very high selectivity for the human CGRP(1) receptor.

Die Sprache des Wahnsinns. Harald Kaas und sein Erzählband ‘Uhren und Meere’:Harald Kaas and his short story collection 'watches and seas'

This essay examines the only book published by the late Harald Kaas. His collection of short stories Uhren und Meere (1979), dealing with depictions of psycho-pathological states of mind, gained Kaas a short-lived notoriety as he himself was a certified schizophrenic possessing first-hand experience of psychiatric treatment. This essay sets out to investigate whether or to what extent the stories in Uhren und Meere can be understood as a document of the language of madness. It concludes that despite the biographical dimension of his schizophrenic experience, Kaas’s texts fail to voice an as it were unadulterated language of madness. However, when read in conjunction with his quasi-poetological interview statements, it is possible to determine the very nature of madness as a collapse of a logical system of language. Meaning that language cannot actively be used to express madness, while at the same time madness can express itself in a language that we necessarily fail to understand. The language of madness manifests itself as the madness of language.

Novel b-lactams, their antibacterial and pharmacokinetic properties and pre-clinical evaluation

DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY AND INFORMATION SERVICES WITH PRIOR ARRANGEMENT

Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes

It is well established that adenosine receptors are involved in cardioprotection and that protein kinase B (PKB) is associated with cell survival. Therefore, in this study we have investigated whether adenosine receptors (A1, A2A and A3) activate PKB by Western blotting and determined the involvement of phosphatidylinositol 3-kinase (PI-3K)/PKB in adenosine-induced preconditioning in cultured newborn rat cardiomyocytes. Adenosine (non-selective agonist), CPA (A1 selective agonist) and Cl-IB-MECA (A(3) selective agonist) all increased PKB phosphorylation in a time- and concentration-dependent manner. The combined maximal response to CPA and Cl-IB-MECA was similar to the increase in PKB phosphorylation induced by adenosine alone. CGS 21680 (A2A selective agonist) did not stimulate an increase in PKB phosphorylation. Adenosine, CPA and Cl-IB-MECA-mediated PKB phosphorylation were inhibited by pertussis toxin (PTX blocks G(i)/G(o)-protein), genistein (tyrosine kinase inhibitor), PP2 (Src tyrosine kinase inhibitor) and by the epidermal growth factor (EGF) receptor tyrosine kinase inhibitor AG 1478. The PI-3K inhibitors wortmannin and LY 294002 blocked A(1) and A(3) receptor-mediated PKB phosphorylation. The role of PI-3K/PKB in adenosine-induced preconditioning was assessed by monitoring Caspase 3 activity and lactate dehydrogenase (LDH) release induced by exposure of cardiomyocytes to 4 h hypoxia (0.5% O2) followed by 18 h reoxygenation (HX4/R). Pre-treatment with wortmannin had no significant effect on the ability of adenosine-induced preconditioning to reduce the release of LDH or Caspase 3 activation following HX4/R. In conclusion, we have shown for the first time that adenosine A1 and A3 receptors trigger increases in PKB phosphorylation in rat cardiomyocytes via a G1/G0-protein and tyrosine kinase-dependent pathway. However, the PI-3K/PKB pathway does not appear to be involved in adenosine-induced cardioprotection by preconditioning Adenosine A1 receptor .