Role of M2 muscarinic receptor in the airway response to methacholine of mice selected for minimal or maximal acute inflammatory response

Airway smooth muscle constriction induced by cholinergic agonists such as methacholine (MCh), which is typically increased in asthmatic patients, is regulated mainly by muscle muscarinic M3 receptors and negatively by vagal muscarinic M2 receptors. Here we evaluated basal (intrinsic) and allergen-induced (extrinsic) airway responses to MCh. We used two mouse lines selected to respond maximally (AIRmax) or minimally (AIRmin) to innate inflammatory stimuli. We found that in basal condition AIRmin mice responded more vigorously to MCh than AIRmax. Treatment with a specific M2 antagonist increased airway response of AIRmax but not of AIRmin mice. The expression of M2 receptors in the lung was significantly lower in AIRmin compared to AIRmax animals. AIRmax mice developed a more intense allergic inflammation than AIRmin, and both allergic mouse lines increased airway responses to MCh. However, gallamine treatment of allergic groups did not affect the responses to MCh. Our results confirm that low or dysfunctional M2 receptor activity is associated with increased airway responsiveness to MCh and that this trait was inherited during the selective breeding of AIRmin mice and was acquired by AIRmax mice during allergic lung inflammation

Leptin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland

Pineal melatonin synthesis can be modulated by many peptides, including insulin. Because melatonin appears to alter leptin synthesis, in this work we aimed to investigate whether leptin would have a role on norepinephrine- (NE-)mediated melatonin synthesis in cultured rat pineal glands. According to our data, cultured rat pineal glands express leptin receptor isoform b (Ob-Rb). Pineal expression of Ob-Rb mRNA was also observed in vivo. Administration of leptin (1 nM) associated with NE ( 1 µM) reduced melatonin content as well as arylalkylamine-N-acetyl transferase (AANAT) activity and expression in cultured pineal glands. Leptin treatment per se induced the expression of STAT3 in cultured pineal glands, but STAT3 does not participate in the leptin modulation of NE-mediated pineal melatonin synthesis. In addition, the expression of inducible cAMP early repressor (ICER) was further induced by leptin challenge when associated with NE. In conclusion, leptin inhibition of pineal melatonin synthesis appears to be mediated by a reduction in AANAT activity and expression as well as by increased expression of Icer mRNA. Peptidergic signaling within the pineal gland appears to be one of the most important signals which modulates melatonin synthesis; leptin, as a member of this system, is not an exception

Captar lo sensible estéticamente : solución bonaventuriana al reto aristotélico

La llegada del Corpus aristotelicum al mundo occidental suscitó numerosas reacciones, tantas como eran las sensibilidades receptoras. San Buenaventura no es ajeno al pensamiento del Estagirita, y junto a las fuentes patrísticas y bíblicas, los argumentos filosóficos formarán parte en la solución de los problemas. Y si todo el edificio filosófico se vio tocado por la filosofía griega de Aristóteles, y en todo se necesitaba una respuesta, más aún aconteció con el mundo de lo sensible, sobre todo, en los pensadores de la llamada Escuela franciscana, que de una u otra manera manejaron este tema con delicada pericia, toda vez, que el espíritu franciscano reverenciaba la «Hermana naturaleza» y lo sensible como manifestación del Amor de Dios. En especial, nos fijamos en san Buenaventura, y en su esfuerzo por realizar una respuesta original desde las fuentes escolásticas al pensamiento nuevo de la filosofía de la naturaleza aristotélica en el espíritu de Asís. Creemos que es posible realizar una lectura de la epistemología y antropología de la captación de lo sensible en san Buenaventura desde una metafísica-estética de la naturaleza, como alternativa a la filosofía de la naturaleza de corte aristotélico.

The LTTE Proposals for an Interim Self-Governing Authority and Future of the Peace Process in Sri Lanka

The political brinkmanship of the Liberation Tigers of the Tamil Eelam has been illustrated vividly by the way in which it brought forward its proposals for an Interim Self-Governing Authority by exploiting the vulnerabilities of the United National Front Government. In the proposals the LTTE articulated its political intentions in concrete constitutional terms for the first time. The Proposals rationalize the armed struggle and a contractual agreement outside the Constitution. The plenary powers of the ISGA exceed the federal formula; effectively exclude the institutions of the state of Sri Lanka from the North-East; and clear the route for a separate state. This situation demands a redirection of the peace process which requires a clear political vision and a proper strategy with alternative proposals on the part of the government. In the face of present impasse of the peace process the challenges before the new Freedom Alliance government are formidable.

Turkey votes: Part I - The storm before the election. EPC Commentary, 26 March 2014

At an election rally on 20 March 2014, Turkish Prime Minister, Recep Tayyip Erdoğan, declared he wanted to “root out Twitter, no matter what the international community thought”. A few hours later Twitter was shut down. The decision backfired. Turkey’s some 12 million Twitter users immediately found ways to circumnavigate the ban; it highlighted the increasingly authoritarian trend of Erdoğan; and it brought immediate condemnation from numerous foreign leaders. The move has been viewed by many Turks as part of an operation to cover up a corruption probe that has consumed Turkey since 17 December, before key local elections on 30 March. The elections, which will be followed by Presidential election in August and political ones expected in 2015, have become a referendum on Erdoğan’s popularity, and are set to shape Turkey’s political landscape. A lot is at stake as a big win for the ruling Justice and Development Party (AKP) may not only be used by Erdoğan to justify his response to the corruption scandal but also risks consolidating his increasingly authoritarian style of governance.

Color, communism, and common sense.

Reprint of original ed. with imprint: New York, Alliance, 1958.

The man of to-morrow; human evolution impelling man onward to God-consciousness,

Mode of access: Internet.

Dominion and power; or, The science of life and living,

Mode of access: Internet.

Life at its best : a series of studies in the vital doctrines of consciousness, ideal, and effort /

Mode of access: Internet.

The personal atmosphere; ten studies in poise and power.

"Reprint of a chapter bearing the same title which appeared in the first edition of 'Power of will'".

Day dreams /

Mode of access: Internet.

All power is given unto you,

Mode of access: Internet.

Sleep as the great opportunity; or, Psychoma;

Mode of access: Internet.

Direct healing, by Paul Ellsworth [pseud.]

Mode of access: Internet.

Bible mystery and Bible meaning,

Lettered on cover: Revised ed.