1000 resultados para Hatcher, Harlan Henthorne, 1898- Poliomyelitis--Patients--Michigan
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OBJECTIVE To investigate if plasma DNA is elevated in patients with deep vein thrombosis (DVT) and to determine whether there is a correlation with other biomarkers of DVT. BACKGROUND Leukocytes release DNA to form extracellular traps (ETs), which have recently been linked to experimental DVT. In baboons and mice, extracellular DNA co-localized with von Willebrand factor (VWF) in the thrombus and DNA appeared in circulation at the time of thrombus formation. ETs have not been associated with clinical DVT. SETTING From December 2008 to August 2010, patients were screened through the University of Michigan Diagnostic Vascular Unit and were divided into three distinct groups: 1) the DVT positive group, consisting of patients who were symptomatic for DVT, which was confirmed by compression duplex ultrasound (n=47); 2) the DVT negative group, consisting of patients that present with swelling and leg pain but had a negative compression duplex ultrasound, (n=28); and 3) a control group of healthy non-pregnant volunteers without signs or symptoms of active or previous DVT (n=19). Patients were excluded if they were less than 18 years of age, unwillingness to consent, pregnant, on an anticoagulant therapy, or diagnosed with isolated calf vein thrombosis. METHODS Blood was collected for circulating DNA, CRP, D-dimer, VWF activity, myeloperoxidase (MPO), ADAMTS13 and VWF. The Wells score for a patient's risk of DVT was assessed. The Receiver Operating Characteristic (ROC) curve was generated to determine the strength of the relationship between circulating DNA levels and the presence of DVT. A Spearman correlation was performed to determine the relationship between the DNA levels and the biomarkers and the Wells score. Additionally the ratio of ADAMTS13/VWF was assessed. RESULTS Our results showed that circulating DNA (a surrogate marker for NETs) was significantly elevated in DVT patients, compared to both DVT negative patients (57.7±6.3 vs. 17.9±3.5ng/mL, P<.01) and controls (57.7±6.3 vs. 23.9±2.1ng/mL, P<.01). There was a strong positive correlation with CRP (P<.01), D-dimer (P<.01), VWF (P<.01), Wells score (P<.01) and myeloperoxidase (MPO) (P<.01), along with a strong negative correlation with ADAMTS13 (P<.01) and the ADAMTS13/VWF ratio. The logistic regression model showed a strong association between plasma DNA and the presence of DVT (ROC curve was determined to be 0.814). CONCLUSIONS Plasma DNA is elevated in patients with deep vein thrombosis and correlates with biomarkers of DVT. A strong correlation between circulating DNA and MPO suggests that neutrophils may be a source of plasma DNA in patients with DVT.
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Back Row: Chris Grieves, Bob Franks, Gregg Willner, Dave Goldwaithe, Mark Slaughter, John Mandich, Pat Watts, James Blue, Nick Labun, Tony Woodford, C. Newhof, Jeff Lawley
9th Row: Steve Knickerbocker, Kyron Williams, Stacy Johnson, John Weisenburger, Bob Hollway, Chip Pederson, Dale Keitz, Tim Malinak, Leon Richardson, Rock Lindsay, Lewis Smith, Woody Brown
8th Row: Scott Smith, Mark Braman, Bob Patek, Jon Giesler, Mark Torzy, Curtis Greer, William Jackson, Jerry Meter, Rick Leach, Dave Stavale, Tom Melita
7th Row: Mike Smith, Tom Seabron, Mark DeSantis, Frank Bell, Harlan Huckleby, Gene Johnson, Mark Schmerge, Russell Davis, John Arbeznik, Andy Jackson, Dennis Richardson
6th Row: Joe Holland, Steve Nauta, Kevin King, Max Richardson, Dave Harding, Mike Kenn, Dominic Tedesco, Jim Pickens, Ray Johnson, Phil Brown, Ken Bush, Roger Bettis
5th Row: Roger Szafranski, Dwight Hicks, Scott Corbin, Mark Donahue, Bill Dufek, Rex Mackall, John Anderson, Derek Howard, Greg Bartnick, Walt Downing, Terry Stefan, Asst. Coach Bill McCartney
4th Row: Asst. Coach Paul Schudel, Curt Stephenson, Rob Carian, Phil Andrews, Eric Phelps, Steve Graves, Gerry Szara, Jim Hackett, Pete Traber, Steve Anderson, Bob Wood, Darrell Truitt, Phil Brumbaugh, Asst. Coach Jack Harbaugh
3rd Row: Asst. Coach Gary Moeller, Asst. Coach Tom Reed, Asst. Coach Jed Hughes, Jerry Zuver, Rick White, Jim Hall, Mike Strabley, Jerry Vogele, Jim Smith, Rob Lytle, John Hennessy, Bob Lang, Jim Bolden, John Ceddia, A. Miller, Asst. Coach Dennis Brown
2nd Row: Asst. Coach Tirrel Burton, Asst. Coach Jerry Hanlon, Greg Morton, Tom Jensen, George Przygodski, Mike Holmes, Co-Captain Kirk Lewis, Jeff Perlinger, Steve King, Dan Jilek, Jim Czirr, Bill Hoban, Calvin O'Neal, Chuck Randolph, Asst. Coach Chuck Stobart
Front Row: Mark Elzinga, Jerry Collins, Kurt Kampe, Rick Koschalk, Dave Devich, Co-captain Gordon Bell, Co-Captain Don Dufek, Tim Davis, Keith Johnson, Les Miles, Dave Whiteford, Greg Strinko, Head Coach Bo Schembechler
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Back Row: Assistant Coaches: Larry Gustafson, Bob Thornbladh, Jerry Hanlon, Tirrel Burton, Dennis Brown, Chuck Stobart, Paul Schudel, Gary Moeller, Bill McCartney, Jack Harbaugh, Tom Reed, Dave Elliott, Tim Davis, Lou Angelo, Eqp. Mgr. Jon Falk, Trainer Lindsy McLean
8th Row: Roger Gaudette, Jim Kozlowski, Virgil Williams, Chris Godfrey, Ron Pratl, Dick Novak, Doug Marsh, Irvin Johnson, Keith Gilmore, Jim Humphries, * , Dan Murray, * , Dave Angood
7th Row: Mike Harden, Mel Owens, Michael Davis, George Lilja, Mark Kochanski, John Powers, Chuck Hetts, Bob Taylor, Garrett Quinn, Mike Jolly, Ralph Clayton, John Wangler, David Payne
6th Row: Gerald Diggs, Gary Weber, Lawrence Reid, Gene Bell, Ron Simpkins, Roosevelt Smith, Lewis Smith, William Jackson, Stacy Johnson, Jeff Bednarek, Mike Leoni, Tony Leoni, Jay Allen, Larry Crockett
5th Row: Woody Brown, Gregg Willner, Chris Grieves, Tim Malinak, Mark Braman, * , Jon Giesler, Dave Kadela, Kyron Williams, * , * , Nick Labun, Tom Keller, * .
4th Row: Mgr. Bob Brown, Chip Pederson, Bob Patek, Dale Keitz, Curtis Greer, Tom Seabron, Jerry Meter, John Arbeznik, Mark DeSantis, Bob Hollway, Tom Melita, Mark Torzy, Rock Lindsay, Ed Kasparek
3rd Row: Roger Bettis, * , Dave Harding, Kevin King, Steve Nauta, Max Richardson, Dom Tedesco, Mark Schmerge, Gene Johnson, Russell Davis, Rick Leach, Greg Bartnick, Harlan Huckleby, Mike Smith, Ray Johnson, * .
2nd Row: Roger Szafranski, Jim Pickens, Dwight Hicks, Mark Donahue, Walt Downing, Steve Anderson, Eric Phelps, Rick White, Curt Stephenson, Phil Andrews, Steve Graves, John Anderson, Bill Dufek, Mike Kenn, Derek Howard, Rex Mackall
Front Row: Jim Hackett, Gerry Szara, Jerry Zuver, John Hennessy, Greg Morton, Co-Capt. Calvin O'Neal, Co-Capt. Kirk Lewis, Co-Capt. Rob Lytle, Jim Smith, Bob Wood, Jim Bolden, Bob Lang, Jerry Vogele, John Ceddia, Head Coach Bo Schembechler
* = left the team
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Back Row: Asst. coaches Bob Thornbladh, Tom Reed, Jerry Hanlon, Tirrel Burton, Tim Davis, Bill McCartney, Jack Harbaugh, Paul Schudel, Dennis Brown, Don Nehlen, Barry Pierson, Jerry Zuver, Eqp. Mgr. Jon Falk, Trainer Lindsy McLean
8th Row: Marcus Bond, Chuck Christian, Greg Wunderli, Kurt Becker, Tony Osbun, Dan Kwiatkowski, Tom Wandersleben, Fred Motley, Andy Cannavino, Mike Kligis, Jim Breaugh, Oliver Johnson
7th Row: Kirk Yearian, B.J. Dickey, Alan Mitchell, Rodney Feaster, Stanley Edwards, Mike Trgovac, Dave Nicolau, Jeff Jackson, Neal Ginley, Kelley Keough, John Prepolec, Ben Needham, Stuart Harris, Rick Jones
6th Row: Derek Williams, Tony Woodford, Jay Allen, James Humphries, David Payne, Tom Keller, Ron Pratl, Rich Novak, David Angood, Craig Page, Dan Murray, Thomas Moss, Larry Jones, Brian Virgil
5th Row: Roger Gaudette, Virgil Williams, Gerald Diggs, Gene Bell, Dave Kadela, Gary Quinn, Ralph Clayton, Chuck Hetts, Mel Owens, Gary Weber, John Wangler, Keith Gilmore, Irvin Johnson, Tony Leoni, Jim Kozlowski
4th Row: Sr. Mgr. Don DiPaolo, Nick Labun, Mike Harden, Michael Davis, Lawrence Reid, Mike Jolly, John Powers, Chris Godfrey, Jeff Bednarek, George Lilja, Mike Leoni, Doug Marsh, Ron Simpkins, Roosevelt Smith, Gregg Willner, Tim Malinak
3rd Row: Ed Kasparek, Mark Braman, Bob Patek, Stacy Johnson, Dale Keitz, John Arbeznik, Curtis Greer, Jon Giesler, Chip Pederson, Mark DeSantis, Mark Torzy, Rock Lindsay, William Jackson, Bob Hollway, Tom Melita
2nd Row: Max Richardson, Curt Stephenson, Derek Howard, Steve Graves, John Anderson, Bill Dufek, Mark Donahue, Co-captain Walt Downing, Garry Szara, Mike Kenn, Rick White, Dominic Tedesco, Jim Pickens, Kevin King, Co-captain Dwight Hicks, Head Coach Bo Schembechler
Front Row: Raymond Johnson, Roger Bettis, Mike Smith, Russell Davis, Tom Seabron, Gene Johnson, Steve Nauta, Rex Mackall, Greg Bartnick, Dave Harding, Mark Schmerge, Jerry Meter, Rick Leach, Harlan Huckleby, Woody Brown
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Back Row: Coaches Bob Patek, Jerry Zuver, Mike Gittleson, Milan Vooletich, Dennis Brown, Jack Harbaugh, Bill McCartney, Jerry Hanlon, Don Nehlen, Tirrel Burton, Paul Schudel, Bob Thornbladh, Barry Pierson, Mike Smith, Curt Stephenson, Trainer Lindsy McLean, Eqp. Mgr. Jon Falk.
9th Row: Kevin Smith, Doug Agnew, * , Mike Butts, Steve Zarnata, Brad Fischer, Kevin Gilligan, * , Karl Tech, Jerome Jelinek, Bill Welch, * , Vince Shaw, Mgr. Nick Uriah
8th Row: Marion Body, Dave Brewster, Rich Strenger, Sanford Washington, Steve Reilly, Tom Neal, Norm Betts, Mike Petsch, Mike Lemirande, Gary Snell, Jeff Reeves, Tony Jackson, Jeff Felten, Tony Kelsie
7th Row: Mike Webster, Butch Woolfolk, Cedric Coles, Bubba Paris, Chuck Rowland, Ed Muransky, Mark Warth, Tom Garrity, Robert Thompson, Jim Paciorek, Gary Lee, Zeke Wallace, Brian Carpenter, John Sandberg
6th Row: Tom Moss, Tim Carrier, Jay Allen, Jim Breaugh, Larry Jones, David Angood, Tom Wandersleben, Fred Motley, Dave Payne, Rod Vaughn, Gasper Calindrino, Kevin Long, Bryan Virgil, *
5th Row: Brad Bates, Irvin Johnson, Kelly Keough, Tom Keller, Rick Novak, Ben Needham, Oliver Johnson, Jeff Jackson, Dan Kwiatkowski, John Prepolec, Greg Wunderli, Kurt Becker, Tony Osbun, Mike Kligis, Chuck Christian
4th Row: Craig Page, B.J. Dickey, Rodney Peaster, Dan Murray, Andy Cannavino, Dave Nicolau, Stanley Edwards, Michael Davis, Mike Trgovac, Stuart Harris, Roger Gaudette, Jim Kozlowski, Alan Mitchell, Rick Jones, Head Coach Bo Schembechler
3rd Row: Gerald Diggs, Tony Leoni, Roosevelt Smith, Gary Weber, Lawrence Reid, Mel Owens, George Lilja, John Powers, Chris Godfrey, John Wangler, Gene Bell, Michael Harden, Mike Leoni, Gary Quinn, Jim Humphries
2nd Row: Gregg Willner, William Jackson, Mike Jolly, Ralph Clayton, Chip Pederson, Rock Lindsay, John Arbeznik, Ron Simpkins, Doug Marsh, Dale Keitz, Tom Melita, Mark Torzy, Tim Malinak, Ed Kasparek, Chuck Netts
Front Row: Mark Braman, Mark DeSantis, Mark Schmerge, Curtis Greer, Greg Bartnick, Harlan Huckleby, Co-Captain Russell Davis, Bill Dufek, Rick Leach, Co-Captain Jerry Meter, Gene Johnson, Jon Giesler, Tom Seabron, Steve Nauta, Bob Hollway
* = left the team
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Albert Kahn, architect. In 1918 the old library was demolished and a new front (north facade) was attached to the 1893 stacks and the stacks built in 1916-1917. This was referred to as the (New) General Library until the south stack addition was built in 1967-1970, when the entire library building was named the Harlan Hatcher Graduate Library.
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Albert Kahn, architect. In 1918 the old library was demolished and a new front (north facade) was attached to the 1893 stacks and the stacks built in 1916-1917. This was referred to as the (New) General Library until the south stack addition was built in 1967-1970, when the entire library building was named the Harlan Hatcher Graduate Library.
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Albert Kahn, architect. In 1918 the old library was demolished and a new front (north facade) was attached to the 1893 stacks and the stacks built in 1916-1917. This was referred to as the (New) General Library until the south stack addition was built in 1967-1970, when the entire library building was named the Harlan Hatcher Graduate Library.
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Jenison, Edward S., architect. View is from the northwest. Statue of Benjamin Franklin (gift of class of 1870) is in right foreground.
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Jenison, Edward S., architect. View is from the southwest.
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Jenison, Edward S., architect.
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Ware and Van Brunt, architect. An addition was built to the south in 1898. The 1883 portion was torn down in 1918.
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Black & Black, architects. Dedicated April 17, 1954 and named after Dr. Margaret Bell, chairman of the Program of Physical Education for Women. Left to right: President Harlan Hatcher; Dr. Margaret Bell, director of Women's Physical Ed. program; and H.O. (Fritz) Crisler
