El Greco; an account of his life and works,

Plates printed on both sides.

Significati particolari di ἀπάτη e ἀπατάω nel greco koiné e l’interpretazione di ἀπατῶν καρδίαν αὐτοῦ in Gc 1,26

L.T. Johnson ha interpretado ἀπατῶν καρδίαν αὐτοῦ in Sant 1,26 como “indulging his heart”. La propuesta requiere una revisión de los casos en los que ἀπάτη y ἀπατάω tienen un significado diferente del original “engaño” / “engañar” en varias fuentes antiguas. La investigación ha conducido a la identificación de tres significados del verbo y del nombre, todos ellos relacionados con la semántica del placer y la diversión. En Sant 1:26 podemos admitir el significado de “dar placer” para ἀπατάω. Llegamos a la conclusión, sin embargo, que esta interpretación es muy poco probable y es preferible dar a ἀπατάω el sentido de “engañar”.

Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n 5 14 260), velocity of sound (VOS; n 5 15 514) and BMD (n 5 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n 5 11 452) and new genotyping in 15 cohorts (de novo n 5 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 3 108) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 3 1014). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 3 106 also had the expected direction of association with any fracture (P < 0.05), including threeSNPswithP < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, thisGWAstudy reveals the effect of several genescommon to central DXA-derivedBMDand heel ultrasound/DXAmeasures and points to anewgenetic locus with potential implications for better understanding of osteoporosis pathophysiology.

Dancing and Professional Dancers in Roman Egypt

The main aim of the study is to create a many-sided view of dancing in Roman Egypt (1st - early 4th centuries AD) and especially of the dancers who earned their living by dancing as hired performers. Even though dancers and other performers played a central part in many kinds of festivities throughout the ancient world, research on ancient professional dancers is rare and tends to rest on the ancient literature, which reflects the opinions of the elite. Documentary written sources (i.e., papyri, ostraka) the core of the present study are mentioned rather superficially, easily resulting in a stereotypical view of the dancers. This study will balance the picture of professional dancers in antiquity and of ancient dancing in a more general sense. The second aim characterizes this study as basic research: to provide a corpus of written sources from Greco-Roman Egypt on dancing and to discuss pictorial sources contemporary with the texts. The study also takes into account the theoretical discussion that centres on dancing as a nonverbal communicative mode. Dancers are seen as significant conveyors of social and cultural matters. This study shows that dancers were hired to perform especially in religious contexts, where the local associations on the village level also played an important part as the employers of the performers. These performers had a better standard of living in economic terms than the average hired worker, and dancers were better paid than other performers. In the Egyptian villages and towns, where the dancers performed and lived, the dancers do not seem to have been marginal because they were professionals or because of some ethnic or social background. However, their possible marginality may have occurred for reasons related to the practicalities of their profession (e.g., the itinerant life style). The oriental background of performers was a literary topos reflecting partly the situation in the centres of the empire, especially Rome, where many performers were of other than Roman origin. The connection of dancing, prostitution and slavery reflects the essential link between dance, body and gender: dancers are equated with such professions or socio-legal statuses where the body is the focus of attention, a commodity and a source of sensual pleasure; this dimension is clearly observable in ancient literature. According to the Egyptian documentary sources, there is no watertight evidence that professional dancers would have been engaged in prostitution and very little, if any, evidence that the disapproval of the professional dancers expressed by the ancient authors was shared by the Egyptians. From the 4th century onwards the dancers almost disappear from the documentary sources, reflecting the political and religious changes in the Mediterranean east.

Gene Expression : From Microarrays to Functional Genomics

The time of the large sequencing projects has enabled unprecedented possibilities of investigating more complex aspects of living organisms. Among the high-throughput technologies based on the genomic sequences, the DNA microarrays are widely used for many purposes, including the measurement of the relative quantity of the messenger RNAs. However, the reliability of microarrays has been strongly doubted as robust analysis of the complex microarray output data has been developed only after the technology had already been spread in the community. An objective of this study consisted of increasing the performance of microarrays, and was measured by the successful validation of the results by independent techniques. To this end, emphasis has been given to the possibility of selecting candidate genes with remarkable biological significance within specific experimental design. Along with literature evidence, the re-annotation of the probes and model-based normalization algorithms were found to be beneficial when analyzing Affymetrix GeneChip data. Typically, the analysis of microarrays aims at selecting genes whose expression is significantly different in different conditions followed by grouping them in functional categories, enabling a biological interpretation of the results. Another approach investigates the global differences in the expression of functionally related groups of genes. Here, this technique has been effective in discovering patterns related to temporal changes during infection of human cells. Another aspect explored in this thesis is related to the possibility of combining independent gene expression data for creating a catalog of genes that are selectively expressed in healthy human tissues. Not all the genes present in human cells are active; some involved in basic activities (named housekeeping genes) are expressed ubiquitously. Other genes (named tissue-selective genes) provide more specific functions and they are expressed preferably in certain cell types or tissues. Defining the tissue-selective genes is also important as these genes can cause disease with phenotype in the tissues where they are expressed. The hypothesis that gene expression could be used as a measure of the relatedness of the tissues has been also proved. Microarray experiments provide long lists of candidate genes that are often difficult to interpret and prioritize. Extending the power of microarray results is possible by inferring the relationships of genes under certain conditions. Gene transcription is constantly regulated by the coordinated binding of proteins, named transcription factors, to specific portions of the its promoter sequence. In this study, the analysis of promoters from groups of candidate genes has been utilized for predicting gene networks and highlighting modules of transcription factors playing a central role in the regulation of their transcription. Specific modules have been found regulating the expression of genes selectively expressed in the hippocampus, an area of the brain having a central role in the Major Depression Disorder. Similarly, gene networks derived from microarray results have elucidated aspects of the development of the mesencephalon, another region of the brain involved in Parkinson Disease.

El estado actual de la “third quest” o “tercera búsqueda” del Jesús histórico

El presente estudio ofrece un panorama actualizado acerca del estado de la “Investigación sobre el Jesús histórico” en su última etapa conocida como “La Tercera Búsqueda” o “Third Quest”. Al respecto, se presentan el marco general de la Investigación sobre la vida de Jesús, “La Tercera Etapa”, las “imágenes” de Jesús de Nazaret, las Perspectivas y la relevancia de la “Tercera Búsqueda”. Sin una pretensión de exhaustividad, el autor plantea esta aproximación como parte de un plan más amplio que se propone el Grupo de Investigación “Judíos y cristianos en los procesos culturales del mundo helenístico-romano”: una mirada más abarcadora de las “Tres búsquedas”.

Fenómenos sublunares en Plinio y Séneca : identificación y traducción

Resumen: La identificación de los fenómenos considerados sublunares en la Antigüedad a partir de la terminología latina es particularmente dificultosa. Nuestra propuesta es considerar los términos que aparecen en las enumeraciones de Plinio y Séneca tomando como parámetro de referencia la nomenclatura astronómica moderna y como hipótesis la de que las observaciones antiguas, por personas de gran capacidad de observación en un cielo sin contaminación lumínica pueden compararse a las que podemos obtener hoy a través de la astrofotografía. La conclusión es que, dado que en la Antigüedad grecolatina cada fenómeno se reportaba con la misma fórmula descriptiva, es posible determinar la equivalencia entre los términos romanos y los actuales (cometas, meteoros, etc.), como paso previo a adoptar una decisión traductiva, ya sea que los consideremos términos científicos o culturalmente específicos.

Astarloaren ekarpena euskal gramatikaren ikerketetan

Pablo Pedro Astarloaren jaiotzako 250. urteurrena dela eta, Durangon, 2002-VI-29an Euskaltzaindiaren bilera irekian irakurritako txostena

Autrigones, caristios, várdulos y berones. Contribuciones historiográficas (1983-2003) relativas a su evolución en época prerromana y romana

[ES] Se presenta un balance historiográfico con las propuestas y debates relevantes, originados a partir de la información, revisada o relativa a nuevos hallazgos, transmitida para estos grupos de población en los testimonios directos, arqueológicos, epigráficos o numismáticos, así como en las referencias correspondientes a autores greco-latinos.

Wastewater treatment plant inspection program, fiscal year 2006 and 2007 data report

This data report includes the results from Alachua County Environmental Protection Department’s inspections of wastewater treatment plants (WWTP) within Alachua County during the 2006 and 2007 fiscal years (October 2005 – September 2007). Groundwater monitoring data provided to the Florida Department of Environmental Protection Department by the WWTP operators is included for those treatment plants that are required to submit this information (PDF has 44 pages.)

Recetarios médicos medievales basados en el aguardiente, el vino y otros ingredientes

Con motivo de mis investigaciones encaminadas a la publicación de las ediciones críticas de los manuscritos inéditos de la Leyenda, Estatutos, Usos y Costumbres de la Orden de S. Juan de Jerusalén, redactados en catalán y occitano , tuve la oportunidad de consultar diversos manuscritos (SS.XIV-XV) redactados en latín, catalán y castellano antiguo , así como obras y artículos especializados en torno a la concepción griega del pneuma, la destilación del vino, recetarios antiguos y en particular la concepción del galenismo y su transmisión al mundo greco-bizantino, a la ciencia árabe y de ésta a la cristiandad bajo-medieval.

Celiac disease in the Mediterranean area

Background: The World Gastroenterology Organization recommends developing national guidelines for the diagnosis of Celiac Disease (CD): hence a profile of the diagnosis of CD in each country is required. We aim to describe a cross-sectional picture of the clinical features and diagnostic facilities in 16 countries of the Mediterranean basin. Since a new ESPGHAN diagnostic protocol was recently published, our secondary aim is to estimate how many cases in the same area could be identified without a small intestinal biopsy. Methods: By a stratified cross-sectional retrospective study design, we examined clinical, histological and laboratory data from 749 consecutive unselected CD children diagnosed by national referral centers. Results: The vast majority of cases were diagnosed before the age of 10 (median: 5 years), affected by diarrhea, weight loss and food refusal, as expected. Only 59 cases (7.8%) did not suffer of major complaints. Tissue transglutaminase (tTG) assay was available, but one-third of centers reported financial constraints in the regular purchase of the assay kits. 252 cases (33.6%) showed tTG values over 10 times the local normal limit. Endomysial antibodies and HLA typing were routinely available in only half of the centers. CD was mainly diagnosed from small intestinal biopsy, available in all centers. Based on these data, only 154/749 cases (20.5%) would have qualified for a diagnosis of CD without a small intestinal biopsy, according to the new ESPGHAN protocol. Conclusions: This cross-sectional study of CD in the Mediterranean referral centers offers a puzzling picture of the capacities to deal with the emerging epidemic of CD in the area, giving a substantive support to the World Gastroenterology Organization guidelines.