Hans Krakauer and Elizabeth Krakauer nee Gottschalk; Boston, New York. Portraits Couples

Photograph taken in front of the house in Boston, in upstate New York outside of Buffalo, where in 1939 they set up their private medical practice. After WWII, they built a new house next door.

Henny Molling nee Meyerhof, Therese Gottschalk nee Molling, Kurt, Elizabeth and Hal Gottschalk on the beach; Norderney, Germany.

Sitting in the Strandkorb (beach chair) at Norderney are Henny Molling and Therese Gottschalk; sitting in the sand are Kurt, Elizabeth and Hal Gottschalk

Elizabeth Krakauer nee Gottschalk in an unknown early Krakauer apartment.

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Studio portrait of Elizabeth Krakauer nee Gottschalk; Hannover, Germany.

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Therese Godshaw (Gottschalk) nee Molling reading with her daughter Elizabeth; Hannover, Germany.

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Wedding portrait of Hans Krakauer and Elizabeth Gottschalk; Hannover, Germany. Portraits Couples

In the apartment on Ruemkorffstrasse that the Gottschalks occupied after being forced to sell their house.

Unidentified man, Elizabeth Krakauer nee Gottschalk and Hans Krakauer on board the ship Koenigstein traveling from Antwerp to New York City on their emigration voyage from Germany.

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Elizabeth Krakauer nee Gottschalk with her mother-in-law Auguste Krakauer nee Mayer in front of a house.

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Elizabeth nee Gottschalk and Hans Krakauer's first house in Boston with descriptions on the picture; Boston, Erie County, New York.

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Portrait of Liesel (Elizabeth) Gottschalk as a baby; Hannover, Germany.

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Portrait of Liesel (Elizabeth) Gottschalk with her grandfather Adolf Molling; Germany.

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Portrait of siblings Hans Ludwig (Hal) and Elizabeth Gottschalk.

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New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.