Wiener Juden-Album für das Jahr 1852 : den p.t. Herren Juden ... mit bes. Zärtlichkeit gewiedmet

von Bertold

Das Judenthum u. die neueste Literatur : krit. Versuch

Berthold Auerbach

Ueber unveröffentlichte Schriften jüdischer Astronomen des Mittelalters

von B. Cohn

Lieder des Ghetto

von Morris Rosenfeld. Autor. Übertr. aus d. Jüd. von Berthold Feiwel mit Zeichnungen von E. M. Lilien

Junge Harfen : eine Samml. jungjüd. Gedichte

hrsg. von Berthold Feiwel

Heimatgeschichte der badischen Juden seit ihrem geschichtlichen Auftreten bis zur Gegenwart

von Berthold Rosenthal. Mit e. Urkundennachbildung, 10 Lichtbild. u. e. Geschichtskt. von Baden

Zur Judenfrage in Galizien

von P. Berthold (Bertha Pappenheim)

Die Judenmassacres in Kischinew

von Told [d.i. Berthold Feiwel]. Mit e. Weihebl. von E. M. Lilien u. Ill.

Tabellen enthaltend die Zeitangaben für den Beginn der Nacht und des Tages für die Breitengrade + 66 bis -38'' : zum Gebrauch f. d. jüd. Ritus

berechnet u. zsgest. von B. Cohn

Stammtafeln der Familie Speyer

(Zusammengest.: auf Veranlassung der Herren James u. Edgar Speyer von Berthold Baer)

[111In-DOTA]LTT-SS28, a first pansomatostatin radioligand for in vivo targeting of somatostatin receptor-positive tumors

Radiolabeled pansomatostatin-like analogues are expected to enhance the diagnostic sensitivity and to expand the clinical indications of currently applied sst2-specific radioligands. In this study, we present the somatostatin mimic [DOTA]LTT-SS28 {[(DOTA)Ser1,Leu8,D-Trp22,Tyr25]SS28} and its 111In radioligand. [DOTA]LTT-SS28 exhibited a pansomatostatin-like profile binding with high affinity to all five hsst1-hsst5 subtypes (IC50 values in the lower nanomolar range). Furthermore, [DOTA]LTT-SS28 behaved as an agonist at hsst2, hsst3, and hsst5, efficiently stimulating internalization of the three receptor subtypes. Radioligand [111In-DOTA]LTT-SS28 showed good stability in the mouse bloodstream. It displayed strong and specific uptake in AR42J tumors 4 h postinjection (9.3±1.6% ID/g vs 0.3±0.0% ID/g during sst2 blockade) in mice. Significant and specific uptake was also observed in HEK293-hsst2-, HEK293-hsst3-, and HEK293-hsst5-expressing tumors (4.43±1.5, 4.88±1.1, and <3% ID/g, respectively, with values of <0.5% ID/g during receptor blockade). In conclusion, the somatostatin mimic [111In-DOTA]LTT-SS28 specifically localizes in sst2-, sst3-, and sst5-expressing xenografts in mice showing promise for multi-sst1-sst5 targeted tumor imaging.

[DOTA]Somatostatin-14 analogs and their (111)In-radioligands: effects of decreasing ring-size on sst1-5 profile, stability and tumor targeting.

Multiple somatostatin receptor (sst)-subtype expression has been manifested in several human tumors. Hence, the availability of radiopeptides retaining the full pansomatostatin profile of the native hormone (SS14) is expected to increase the sensitivity and broaden the clinical indications of currently applied sst2-preferring cyclic octapeptide radioligands, like OctreoScan(®) ([(111)In-DTPA]octreotide). On the other hand, SS14 has been excluded from clinical use due to its rapid in vivo degradation. We herein present a small library of seven novel cyclic SS14-mimics carrying at their N-terminus the universal chelator DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) for stable binding of medically useful radiometals, like (111)In. By decreasing the number of amino acids composing the ring in their structure from 12 up to 6 AA, we induced important changes in key-biological parameters in vitro and in vivo. In particular, we observed unexpected changes and even total loss of sst1-5-affinity (6AA-ring), as well as weaker sst2-internalization efficacy as the ring size decreased. In contrast, in vivo stability increased with decreasing ring size, reaching its maximum in the 6AA-ring analogs. Interestingly, only the 12AA- and 9AA-ring members of this series showed sst2-specific uptake in AR4-2J tumors in mice revealing the prominent role of ring size on the biological response of tested SS14-derived radioligands.

Katalog hebräischer und jüdischer Schriften

H. Berthold Schriftgiessereien und Messinglinien-Fabriken, Aktien-Gesellschaft. [Zum Geleit ... Joseph Tscherkassky]

Briefe an seinen Freund Jakob Auerbach : ein biographisches Denkmal Band 2

In Fraktur