MILA: estudo sobre o processo de unificação e funcionamento do mercado integrado latino-americano

O presente trabalho apresenta em sua essência informações sobre o processo de unificação das Bolsas de Valores do Chile (BVS), Peru (BVL) e Colômbia (BVC) - que deu origem ao Mercado Integrado Latino-Americano (MILA) - com o objetivo de compreender o funcionamento desse sistema inovador, e possibilitar o acompanhamento dos efeitos futuros que dele ocorram

A influência do ciclo estral no comportamento das linhagens de ratos congênica SLA16 e isogênica SHR

Several studies use only male rats in their experiments, even with all the evidence of differences between the sexes, not only in the reproductive behavior but also in the development of diseases. This absence of studies using female rats is due in part to the estrous cycle. It is known that one estrous cycle lasts four to 5 days and consists of four phases: proestrus, estrus, metestrus and diestrus. Ramos et al. (1999) identified and mapped a QTL in an F2 population derived from interbreeding of strains of SHR (spontaneously hypertensive rats) and Lewis (LEW) rats and found, on chromosome 4, the first QTL of the world related to anxiety in rats. After several backcrosses between SHR and LEW strains, it was developed a congenic strain called SLA16, to refine the study of this QTL. This QTL corresponds to a large genomic region, approximately 75 million basepairs (Mb), and was first called Ofil1 (inner open field locomotion 1). Currently it is called Anxrr16 (anxiety-related response region 16) according to the rat genome database (RGD). Izidio et al. (2011) suggested that the natural fluctuation of the hormones in the estrous cycle of female rats could influence the effects of this locus on behavior. That is, females in DP (diestrus-proestrus) present the QTL in the same genomic region that males, while females in EM (estrus-metestrus) do not present it. The effects of the estrous cycle in the SLA16 strain and its isogenic control SHR were analyzed on the elevated plus maze (EPM), black and white box and on the open field test (OF). In the open field test, the SLA16 strain had higher central locomotion (F=5.0, p <0.05) and peripheral locomotion (F=12.6, p <0.01) compared to the SHR strain. In the elevated plus maze test, the SLA16 strain had the higher number of entries (F=9.5, p <0.01) and time spent in the open arms (F=10.3, p <0.01) compared to the SHR strain. Finally, in the black and white box test, the SLA16 lineage spent more time ...

A importância da ciência e tecnologia para o desenvolvimento: um estudo de caso da indústria brasileira de química verde

The objective of the research is to map and analyze the investment, strategies of develop and prospects of green chemical industry in Brazil and show the fundamental importance of basic research and applied research in the development of this industry in recent years. The complementary objectives are: (i) to evaluate the role of the Brazilian government as a catalyst, encouraging the development of green chemistry industry through incentives, subsidies and ease in credit lines; ii) mapping of relationships between companies universities and public research institutes in the field of green chemistry; iii) verification of the strategies in the world stage green chemistry, the course of time; iv) the theoretical issues and national plans, and your practicable; v) continued investment in the area, with the worry of them being affected by any matter cyclical such as the discovery of a large deposit of shale gas in the United States and a technological development of oil extraction in Brazil and vi) the pace of R&D for basic and applied in the country with the passage of time

Análise discursiva de blogs de professores: a produção da identidade na internet

This paper proposes a discursive analysis of teachers‘s blogs , particularly those accessible from the MEC site : http://portaldoprofessor.mec.gov.br/links.html . The aim is to analyze , dialogically, based on Bakhtinian discourse studies the speech of Portuguese language teachers on the internet , and to investigate aspects of the discourse genre blog , this specialized sphere of circulation :whether it is a means of exposing themselves, whether they are professional media extent , reflect about how to produce the identity of the Portuguese language teachers in such discourse . The axes of reflection on identity , in this case , are four: the subject‘sthe discourse about themselvesand their peers , how the subject shows itself tothe analyst - researcher in dialogue with others in history ( teachers , students , interested in issues of language , official documents ), how it can be seen by the analyst - researcher considering using resources ( videos , photos , literary genres, etc. ), how it is seen by those who comment your say

Una lapide in via Mazzini: os sofrimentos em Auschwitz e os desafios da tradução

Giorgio Bassani in his book Una lapide in via Mazzin seeks to show to the readers all the sufferings passed by Italians during the Second World War and emphasized those persists until today. Aiming to make an unprecedented translation of this tale, it is expected that the text provides us great experiences in the language and we could see the actual difficulties and differences with the Portuguese language, despite being considered these languages closed ones. The objective of this work is to produce a translation that allows us to transmit all anxieties and reflections suffered by the main character of the tale. After the war, the survivor of the concentration camp can go back to your city. He appears exactly at the moment is being placed a headstone on the synagogue wall in homage to Jews deported and killed in the camps. Given the gaunt figure of the man with his striped pajamas, the population is driven to rethink their own indifference and , in a way, its share of blame. Thus, the return should be celebrated is rejected and the figure of the survivor becomes a nuisance. The function of the headstone is actually and literally put a stone on the story. To achieve the proposed objective for this work, we analyzed all the chapters of the story Una lapide in via Mazzini and tried to find equivalents in Portuguese. However, we not ignored the traces of meaning that Giorgio Bassani invested in his work. Therefore, it was necessary to use both printed and virtual dictionaries. With the advancement of the translation work, we realized the difficulty of finding appropriate solutions to achieve the desired effect . The fidelity proposed by the author became increasingly difficult as our work progressed. In the course of all the discussions, it was concluded that , in fact , when it comes to translation, maintaining fidelity to the original text in a foreign language is a difficult and laborious process

Vozeamento na pronúncia de uma língua estrangeira: descrição de desvios comuns e como eles afetam o aprendizado do inglês

This paper analyzes voicing occurrences on the coda of Portuguese and English words pronounced by Brazilian speakers. The aim of this kind of analysis is to describe how voicing occurrences affect the realization and perception of foreign words. It was noted that there is a recurrence on the use of unvoiced coda in Portuguese, which was assumed to happen also in English when Brazilian Portuguese speakers uses it as a second language. The recordings were analyzed through Praat, software that generates waveforms and spectrograms, allowing segments to be divided and phonetically transcribed. The analysis proved the assumption to be true, concluding that speakers who had their speeches recorded produced unvoiced codas in fact. Conclusions concerning this take into consideration that, considering how minimal pairs in English can be produced based on coda voicing, there is a possible communication difficulty Brazilians may face due to this fact. But it goes by unnoticed, because this process sounds so natural it hardly is taken as a problem source

Efeitos do FGF2, FGF10 e da BMP15 sobre a maturação nuclear de oócitos bovinos durante a maturação in vitro

O ambiente folicular é responsável por manter o oócito em parada meiótica e pela retomada da mesma posteriormente. A retomada da meiose em momento adequado é de extrema importância para o desenvolvimento de oócitos de alta competência. Portanto, o estudo dos mecanismos reguladores da retomada da meiose é de grande utilidade. Nesse estudo, os efeitos do FGF2, FGF10 e BMP15 sobre a progressão da meiose durante a maturação oocitária in vitro foram testados. Para tanto, complexos cumulus-oócitos (COCs) foram cultivados em meio definido seguindo o delineamento: Interação FGF10 e BMP15: sendo os tratamentos: controle; FGF10 (10ng/mL); BMP15 (100ng/mL); FGF10 (10ng/mL) + BMP15 (100ng/mL); e Dose-Resposta FGF2: sendo os tratamentos: controle e FGF2 nas doses 1, 10 ou 100ng/mL. A fase da meiose foi avaliada após 22h de cultivo por meio de coloração HOESCHT 33342, sendo os oócitos classificados em meiose I ou meiose II. O FGF10 (68%), a BMP15 (62,57%) ou a interação, FGF10+BMP15, (73%) não alteraram a porcentagem de oócitos em MII após a MIV em relação ao controle (69,63%). Assim como, a adição de FGF2 nas doses de 1ng/mL (81,33%), 10ng/mL (84,83%) ou 100ng/mL (83%) também não alteraram a porcentagem de oócitos em MII em relação ao controle (79,83%)

São Bernardo: construção do romance pela memória

This paper concentrates on demonstrating that the novel called São Bernardo ,written by Graciliano Ramos, utilizes some literary strategies that cause the effect of being built by rememorizations, which is a vital aspect of several of the author’s titles. Such objective is reached via the analyses of how the following narrative categories: focalization, narrator, characters, story and time converge toward the elaboration of the memory and the comparison between this construction on São Bernardo and Angústia. In order to be successful on this task, three groups of study constitute our theoretical basis: a) critical essays concerning Graciliano Ramos; b) theoretical propositions about the narrative categories; c) academic articles on the constitution of memory. Papers composed by Antonio Candido, Alfredo Bosi, Sonia Brayner, Luís Costa Lima and others are part of the first group. The second one is constituted by propositions of Gérard Genette, Benedito Nunes etc. Finally, on the last one, we find Paul Ricouer and Henri Bergson

Implicações da União Econômica e Monetária Europeia sobre a política econômica dos PIGS: uma análise sobre a crise das dívidas soberanas

The present work intends to analyze the impacts of the European Economic and Monetary Union in the economic policies of the countries named PIGS, with an analysis about the sovereign debt crisis, in view of the autonomy loss to adopt own monetary and exchange rate policies of countries with different levels of development

Modelagem de processos de negócios: uma proposta no serviço de atendimento ao usuário da biblioteca da Unesp Guaratinguetá

This work is a study on the Technical Service Library and Documentation Prof. Carlos Alberto de Buarque Borges , on the Faculdade de Engenharia de Guaratinguetá , regarding to the service user , aiming to detect and analyze the current problems and suggesting improvements that could result in optimization of care and increased quality of services. For this, was chosen the methodology of Business Processes Modeling, which enabled the detailing of the processes implemented in the library and the identification the critical points , as low investment and short number of employees, which made possible suggest ways to improve the quality of service to users, as awareness campaigns and the implementation of an system to input the literature needed for each course

Determinação de genes potencialmente responsivos à radiação ionizante através de aprendizado de máquina

A predição da resposta do tumor a radioterapia e a questão mais importante durante o tratamento de pacientes com câncer. Como consequência, a predição de genes que sejam responsivos a radiação ionizante e uma possibilidade para a melhoria dos resultados clínicos e a otimização das doses as quais os pacientes são submetidos ao longo do tratamento. Juntamente com esses dados, é possível obter respostas sobre os mecanismos de resistência a radiação dos tumores e até mesmo a identificação de biomarcadores responsáveis pela resistência a radiação ionizante que podem ser potenciais para o desenvolvimento de novas drogas visando a proteção de tecidos saudáveis. A determinação experimental dos genes que sejam responsivos à radiação ionizante é algo caro e que demanda muito tempo e trabalho; porém, se utilizarmos uma forma computacional de direcionar os estudos experimentais diretamente aos genes que têm mais potencial para serem responsivos à radiação ionizante, as pesquisas podem ser mais direcionadas e específicas. Para determinar essa característica, construímos, analisamos e determinamos os dados da topologia da rede integrada de interações moleculares entre genes humanos, contendo interações físicas entre proteínas, interações metabólicas e interações de regulação transcricional. Os dados topológicos foram utilizados como atributos de treinamento para o aprendizado de máquina, no qual os genes conhecidamente responsivos à radiação ionizante foram apresentados a um algoritmo de árvore de decisão que gerou modelos de predição com índices de sensibilidade e precisão de 5% e 72%, respectivamente. Os índices de acerto obtidos para os conjuntos de teste foram satisfatórios, retornando 91% dos genes conhecidos como responsiveis à radiação ionizante utilizados para o treinamento da árvore de decisão. Nós aplicamos o modelo de predição na rede integrada e atribuímos probabilidades ...

Terapia fotodinâmica - Aplicações em lesões cutâneas

Photodynamic therapy is a method of healing skin lesions , in addition to radiotherapy and brachytherapy are commonly used in the treatment of skin cancers , but it is still little known in Brazil , consisting of the application to the skin of a drug in the form of cream or lotion ( photosensitizer ) . It is absorbed by tumor cells and subsequently activated by light device , that wavelength of light in the order of 630 nanometers , promoting the selective destruction of cancer cells while preserving healthy cells around the lesion . It can be considered highly effective for treatment of skin cancer types of non-melanoma ( basal cell carcinoma , 85-100 % success in curing [ 3 ] , and Bowen's disease), actinic keratoses , which are precancerous lesions and still no studies that prove also action in the treatment of acne and aging caused by the sun . And the advantage of this treatment is that , when indicated , replace the surgical procedure , selectively treating the diseased cells . Thus, it offers better cosmetic results, reducing the risk of scarring [ 4 ]

A crítica de Mandelbrot: normalidade como exceção e não como regra

Starting with a brief introduction about the evolution of asset pricing models, we seek here to introduce the critique made by Benoit Mandelbrot about using the normality hypothesis when building such models. This critique arises when empirical and theoretical models where confronted and the expected results diverged from the ones obtained. Next, we reproduce Mandelbrot alternative which he believes is sufficient to solve the main problems implied by the normality hyphotesis

Gestão de estoque em uma empresa de varejo de produtos de limpeza e higiene pessoal

The deficiency in the product inventory management is common in small businesses, affecting several areas, especially the purchasing department that has difficulty in performing their tasks, acquiring the supplier's products at the time and in the most appropriate amount. Especially in the retail sector, the loss of quality of services is visible, because the availability of the product when there is demand is essential for the occurrence of sales and customer satisfaction. In this study, looking to improve inventory management in a retail company of cleaning products and personal hygiene, apply the classification method ABC (or Pareto Rule) to segment the available products. Thus are adopted buying criteria of new products based on the concepts of economic order quantity, safety stock and resupply point. The results show the feasibility of this procedure adopted because it was possible to propose an improved inventory management in a simple and effective way, contributing to company's competitive advantage