F同位素的反应总截面测量和~(17)F可能的质子皮结构

应用透射法对中能区F同位素与C靶的反应总截面进行了测量 .发现17F的反应总截面比其邻近同位素的反应总截面稍有增强 .用Glauber模型和BUU模型对F同位素进行了差异因子d的分析 .17F的差异因子d比其附近同位素稍有增强 .分析结果表明17F可能存在质子皮结构 .

重离子束治癌相关生物学效应及机理研究

重离子束治癌是当今放射治疗中最科学、最先进、最有效的方法，是有代表性的高技术。目前仅有美、日、德实现了该技术，并已取得常规疗法难以实现的疗效。我国近年来开展了“重离子束治癌技术的基础研究”，其中，放射生物学及机理研究是重要内容。本论文从细胞、DNA分子、以及动物个体的三个不同层次上分别研究了重离子束治癌相关的生物学问题。在细胞研究方面。采用HeLa、B 16两种细胞分别研究了X一射线和重离子在水介质中入射的深度与相应细胞的存活率(1一失活率)，结果表明：X一射线对细胞的损伤随深度而逐渐衰减(或细胞存活随深度逐渐增加)，而重离子对细胞的损伤则为Bragg曲线(或细胞存活为倒Bragg曲线)。研究了25MeV／u ~(40)Ar~(14+)辐照人肝癌细胞SMMC一7721的微核及存活的动态变化，结果表明： 单次照射与分次照射的微核率随时间的变化规律在96h内没有明显区别，受照(单次、分次) 肝癌细胞的存活数随时间表现出衰减趋势，微核率与细胞存活数关系的动态变化为负相关性。研究了6MV X-射线和125．5keV／μm的重离子辐照B 1 6、V79细胞的2Gy存活率(SF2)，结果表明：B16和V79细胞的存活率(P<0．01)依赖于不同的辐射性质(X-射线、~(12)C离子)，其X-射线与~(12)C离子辐射这两种细胞的存活率之比分别为5．4和1．43，即~(12)C离子辐射增强了X-射线抗性细胞系的敏感性，从而显示了重离子治疗癌症的优势。研究了125．5keV／um的碳离子辐照小鼠黑色素瘤B16、人的宫颈癌HeLa、中国仓鼠肺V79、人的肝癌SMMC-7721四种细胞的相对生物学效率(RBE)，得．到了RBE依赖于细胞种类的关系、RBE随细胞存活水平的升高而增加的关系、以及当LET≥125．5keV／μm时，RBE随着LET的增大而变小的关系。在DNA分子研究方面。研究了125．5keV／μm~(12)C~(6+)辐照小鼠黑色素瘤B 16、中国仓鼠肺V79、人的宫颈癌HeLa、人的肝癌SMMC一7721细胞的灵敏度(由D50表示)、DNA双链断裂(DSB)和DNA双链断裂片段分布，结果表明：细胞敏感性与DNA双链断裂之间没有一致的关系，提出了细胞辐射敏感性的一种可能的分子机理，即DNA序列敏感性位点协同DNA双链断裂互补性机理。由此解释了四种细胞系的不同敏感性问题。在动物个体研究方面。研究了57．28MeV／u氧离子50Gy一次性局部照射对B16黑色素瘤小鼠肿瘤生长的抑制作用，并观测了受照小鼠的死亡情况，结果表明：照射B16黑色素瘤后第10天观察，肿瘤生长延迟为6天、肿瘤抑制率为66％，耐受剂量小于50Gy。研究了50MeV／u ~(12)C~(6+)离子辐照对小鼠移植性肿瘤S180的抑制作用、控制率、治愈率和病理组织学变化，结果表明：各剂量组对S180肉瘤的抑制作用均大于90％，高剂量组抑瘤作用明显强于低、中剂量组(P

不同经营方式对黑土水稳性团聚体组成及微粒有机质积累分布的影响

长期定位试验研究松嫩平原典型中厚黑土区水稳性团聚体组成和微粒有机质积累分布规律结果表明,不同培肥模式和耕作制度对水稳性团聚体组成有很大影响,耕地团聚体组成以<1mm水稳性团聚体占绝对优势;微粒有机碳(POM C)主要存在于水稳性大团聚体中,且其含量随粒级减小而下降,这对维持耕地黑土大团聚体(>0 .2 5mm)水稳定性起重要作用

鸡粪高效降解菌群对堆肥的影响

为明确自行筛选开发的高效降解菌对鸡粪发酵的影响,分析研究了其堆肥的主要腐熟指标。结果表明,加入高效降解菌剂的堆肥处理方法温度相对较高,脱水快,pH值适宜,C/N调整较好,种子发芽指数高,堆肥后营养养分含量高,且大肠菌群数量少,堆肥效果较好。

Recent 2000-year geological records of mud in the inner shelf of the East China Sea and their climatic implications

AXIS(14)C dating and grain-size analysis for Core DD2, located at the north of the Yangtze River-derived mud off the Zhejiang-Fujian coasts in the inner shelf of the East China Sea, provide us a high-resolution grain-size distribution curve varying with depth and time. Data in the upper mud layer of Core DD2 indicate that there are at least 9 abrupt grain-size increasing in recent 2000 years, with each corresponding very well with the low-temperature events in Chinese history, which might result from the periodical strengthening of the East Asian Winter Monsoon (EAWM), including the first-revealed maximum temperature lowering event at around 990 a BP. At the same time, the finer grain size section in Core DD2 agrees well with the Sui-Tang Warming Period (600-1000 a AD) defined previously by Zhu Kezhen, during which the climate had a warm, cold and warm fluctuation, with a dominated cooling period of 750-850 a AD. The Little Ice Age (LIA) can also be identified in the core. It starts around 1450 a AD and was followed by a subsequent cooling events at 1510, 1670 and 1840 a AD. Timing of these cold events revealed here still needs to be further verified owing to some current uncertainty of dating we used in this study.

Records of the East Asian winter monsoon from the mud area on the inner shelf of the East China Sea since the mid-Holocene

AMS(14)C dating and analysis of grain size, major elements and clay minerals were applied to Core MZ01 from the mud area on the inner shelf of the East China Sea. Based on the environmentally sensitive grain size, clay mineral and major element assemblages, the history of the East Asia winter monsoon since the mid-Holocene could be reconstructed. These three proxies, mean grain size (>9.71 mu m), chemical index of alteration (CIA) and ratio of smectite to kaolinite in particular, show similar fluctuation patterns. Furthermore, 10 extreme values corresponding to the contemporary cooling events could be recognized since the mid-Holocene; these extreme values are likely to have been caused by the strengthening of the East Asia winter monsoon. The cooling events correlated well with the results of the delta O-18 curves of the Dunde ice core and GISP2, which therefore revealed a regional response to global climate change. Four stages of the East Asia winter monsoon were identified, i.e. 8300-6300 a BP, strong and unstable; 6300-3800 a BP, strong but stable; 3800-1400 a BP, weak and unstable; after 1400 a BP, weak but stable.

孔石莼多糖及其衍生物的研究

在中国，孔石莼应用于医药方面已有几千年的历史，其煎剂常被当地居民用来治疗中暑和泌尿方面的疾病。实验室以前所做的工作表明，孔石莼的水溶多糖具有很好的抗高血脂活性，本论文在此研究的基础上主要就多糖的长期毒性、一般药理、多糖的衍生化、不同分子量孔石莼多糖的抗氧化活性、衍生物的抗氧化活性和动物调血脂活性进行了研究。 水提醇沉制备多糖，多糖主要由糖醛酸、鼠李糖、木糖、葡萄糖和硫酸根组成，还含有微量的半乳糖、甘露糖和阿拉伯糖。多糖中主要的二糖重复单位为[β-D-Glcp A-(1->4)- α-L-Rhap 3S] 和 [α-L-Idop A-(1->4)- α-L-Rhap 3S]。急性毒性实验表明，KM小鼠对孔石莼多糖的最大耐受量(MTD)大于4000 mg/kg，其腹腔注射雌性小鼠的半致死量(LD50)为408.7 mg/kg，雄性动物为432.7 mg/kg。长期毒性（6个月）实验表明孔石莼多糖无毒反应剂量为1.2 g/kg。一般药理研究表明孔石莼多糖对小鼠中枢神经系统无明显影响，对麻醉犬心血管系统和呼吸系统均无明显影响。 采用过氧化氢降解的方法制备了不同分子量的孔石莼多糖，并且测定了体外抗氧化活性；制备了高硫酸根含量的孔石莼多糖、乙酰化和苯甲酰化孔石莼多糖衍生物，测定了体外抗氧化活性和动物调血脂试验。结果表明，不同分子量的孔石莼多糖其抗氧化活性是不同的，分子量低的孔石莼多糖表现出了较强的抗氧化活性。孔石莼多糖的衍生物其抗氧化活性要优于孔石莼多糖。调血脂动物试验表明，孔石莼多糖以及其衍生物都具有很好的调血脂效果。高硫酸根含量孔石莼多糖的中、低剂量组的调血脂活性要优于高剂量组（低剂量组降低低密度脂蛋白的能力要稍弱于原料），而且，中剂量组与原料组相比，小鼠血清TG明显降低（P＜0.05），LDL－C 明显降低（P＜0.01）。低剂量组乙酰化衍生物降低甘油三酯（TG）和低密度脂蛋白（LDL－C）的能力要优于中高剂量组。对于孔石莼多糖以及衍生物调血脂的机制还需进一步的研究。

Rapid changes in stocks of ciliate microzooplankton associated with a hurricane in the Bohai Sea (China)

The ciliate community in the Bohai Sea (China) was studied from 23 September to 7 October 1998. A hurricane struck the study area between the 2 grid station investigations; which were 6 d apart. The ciliate biomass decreased drastically after the hurricane. The surface ciliate biomass decreased from 0.2-12.3 to 0.02-2.8 mug C l(-1) and the water column ciliate biomass from 2-136 to 0.01-47 mg C m(-2). The ciliate biomass:chlorophyll ratios in the surface water were calculated to be 0.04 to 4.7 (1.41 on average) during the first grid investigation and 0.01 to 1.18 (0.26 on average) during the second grid investigation. Distinct patterns of temporal changes in ciliate abundances were found at different stations both before and after the hurricane.

Photocatalytic degradation of CI Acid Blue 80 in aqueous suspensions of titanium dioxide under sunlight

The dye C.I. Acid Blue 80 (AB80) was easily degraded by TiO2-P25 assisted photocatalysis in aqueous dispersion under irradiation of sunlight. The optimal reaction conditions were [TiO2] = 2.0 g/L, pH = 10, [H2O2] = 5 mmol/L. The photocatalytic reaction followed pseudo-first order kinetics. The adsorption of AB80 onto TiO2 was in accord with Langmuir equation.

基于神经网络和小波变换的车型识别方法研究

车型自动识别分类在不停车收费系统中起着关键的作用，决定了不停车收费系统的可靠性和智能化程度，对提高公路交通系统的管理水平和车辆通行速度具有重要的意义。 本文对现有车型自动识别分类方法进行了分析比较，在此基础上，对采用雷达微波进行车型识别进行了探索和研究，雷达微波车型识别技术与车载电子标签有机结合起来，起到车型二次识别的作用，有效防止各种舞弊行为，控制收费损失。 本文通过MATLAB产生仿真的雷达微波信号，信号中包含了车型的特征信息。再采用小波变换的方法消除噪声，由于车型大小与信号经过小波变换后得到的各层能量分布有关，所以提取其能量分布作为分类识别的特征矢量。设计了BP神经网络的分类器，车型的能量分布特征由车型分类器进行分类，最终得到车辆的类型。 本文在对所设计的神经网络分类器进行训练的时候，对样本采用了改进的模糊C均值算法进行聚类分析，有效地避免了样本集不理想情况下对各类中心隶属度过小的情况，用隶属度作为网络输出训练,使网络容错性更强，更加符合实际分类情况，三个网络分别训练，最后综合判断，提高了分类质量。 本文首先介绍了已有车型自动识别的方法，分析讨论了存在的弊端，然后提出采用雷达微波进行识别的方法，详细介绍了对回波信号进行处理所用到的算法，分析比较各种算法，选择合适的算法用于信号的处理，最后介绍了车型识别硬件仿真平台及软件实现。

Structure of glasses and melts

Wilding, M. C., Benmore, C. J. (2006). Structure and Glasses and Melts. reviews in Mineralogy and Geochemistry, 63 (1), 275-311 RAE2008

Beyond LibGuides: The Past, Present, and Future of Online Research Guides

© 2015, Jon C. Giullian and Ernest A. Zitser.The proliferation of research guides created using the LibGuides platform has triggered extensive discussion touting their benefits for everything from assessment, engagement, and marketing, to outreach and pedagogy. However, there is at present a relative paucity of critical reflection about the product’s place in the broader informational landscape. This article is an attempt to redress this lacuna. Relying primarily on examples from the field of Slavic, East European, and Eurasian studies, the authors briefly describe the evolution of online research guides; identify reasons for the proliferation of Springshare’s product in academic libraries; question whether LibGuides improve learning or reinforce information inequality in higher education; and propose a way to move beyond LibGuides.

Anne McPherson family fonds, 1852-2011 [non-inclusive]

Frank C. (Case) McCordick (1873-1946) was the son of William Henry (1849-1930) and Emily D. Howell (1851-1927) McCordick. William H. McCordick was in the coal business. The McCordick family included Frank Case, Mabel Gertrude, Ethel Howell and Arthur Stanley. Frank C. McCordick was educated in St. Catharines, and worked with his father in the coal business and eventually opened up a leather tanning operation. McCordick was active in the Lincoln Regiment and in 1906 was promoted to captain and in command of Company A, 19th Regiment. He was promoted to major and at the outbreak of war he was sent overseas as a commander of the 35th Battalion of the Canadian Expeditionary Forces (CEF). Upon arrival in France he was made officer commanding the 15th Battalion, King’s Own Yorkshire Light Infantry (KOYLI). After the war and his return to Canada he continued to play an active role in the local military units in the area as well as in Hamilton. After his retirement from the military in 1927 McCordick served as alderman and then mayor of St. Catharines from 1930 to 1931. He was a member of a large number of civic clubs, including St. Catharines Chamber of Commerce, Y.M.C.A., Lion’s Club, St. Catharines Golf Club, Detroit Boat Club, the St Catharines Club, as well as a member of several Masonic lodges. He continued to operate McCordick Tannery and other local investments. In 1903 Frank C. McCordick married May Beatrice Simson, daughter of Thomas E. Simson of Thorold. They had three children, E. (Edward) Frank McCordick, Bruce McCordick and (Margaret) Doris McCordick (m. Hubert Grigaut, d. 1977). The McCordick family resided at 82 Yates Street, near Adams Street. May Simson McCordick (b. 1873) was the daughter of Thomas Edward (1836-1908) and Julia Headlam (1844-1887) Simson of Thorold. Her siblings included: Edward, Frances, John, Augusta, Georgia and Gertrude. E. (Edward) Frank McCordick (1904-1980) was born in St. Catharines, Ont., attended Lake Lodge School in Grimsby, Ridley College in St. Catharines, Beechmont Preparatory School in England, Upper Canada College in Toronto and graduated from Royal Military College in Kingston, Ont. in 1925. Upon graduation he was made a lieutenant in the 10th (St. Catharines) Field Battery. In 1929 he married Helen Stanley Smith, daughter of Stanley George and Mary Walker Smith of St. Catharines. Col. McCordick, now promoted to Major, played an active role in the 10th (St. Catharines) Field Battery, being officer commanding the battery. In late 1939 McCordick headed to England for artillery tactical training and on December 6, 1939 the battery began the long trek overseas. McCordick saw action in Italy and in Holland. Upon his return to Canada at the end of the war he was the Liberal candidate in the federal election for Lincoln County. He remained active in the local military serving as honorary lieutenant-colonel of the 56th Field Regiment (ARCA) and in 1976 as the honorary colonel of the regiment. Col. McCordick held the Efficiency Decoration, the Order of the British Empire, granted in 1945 and was made an officer in the Order of St. John in 1978. He continued to serve his community in various capacities, including the Unemployment Insurance Canada Board, Royal Trust Company and the St. John Ambulance Society. He remained an active member of the alumni of Royal Military College, editing and compiling a newsletter and organizing reunion weekends. He kept in close contact with many of his classmates. Helen Stanley Smith McCordick lived in St. Catharines, Ont., attended Robertson School, and graduated from the University of Toronto in 1926 with a Bachelor of Arts degree in Modern Languages. During the war years (1939-1945) Helen was active in the Transport division of the local branch of the Canadian Red Cross and the Women’s Auxiliary of the 10th Field Battery. In 1932 E. Frank and Helen McCordick welcomed their only child, (Catharine) Anne McCordick. Helen continued to play an active role in her community until her passing in 1997. Stanley George Smith (1865-1960) was born in St. Catharines, Ont., the only child of William Smith (d. June 16, 1876) a native of Edinburgh, Scotland and his wife Hannah Louisa Maria Bulkeley a native of Fairfield, Connecticut. Stanley George Smith married Mary Walker of Guelph, Ont.(d. 1956) Mary was the daughter of Hugh and Elizabeth (d. 1924) Walker. Her siblings included Margaret, Agnes, Jessie, Isabella, Lorne, Ada, Alice, Eva, Alexander and George. Hugh Walker was a prominent fruit and vegetable merchant in Guelph. On 1904 their only child, Helen Stanley Smith was born. He was a post office clerk, and the treasurer for the James D. Tait Co. Ltd., a clothing and dry goods retailer in St. Catharines. The family lived at 39 Church Street in St. Catharines, Ont.

La réponse au Farnésol de Candida albicans : production de biofilms et Parenté génétique

C. albicans est une levure pathogène opportuniste. Elle est un agent causal fréquent des infections muco-cutanées. C. albicans peut alterner entre la forme blastospore et mycélium. Cette dernière forme est impliquée dans la formation des biofilms. Le dimorphisme de C. albicans est contrôlé en partie par le phénomène de perception du quorum (quorum sensing) qui en autre, est associé à la molécule farnésol, produit par cette levure. La présence de cette molécule, inhibe la formation d’hyphe par C. albicans et par conséquent limite la formation de biofilms. Certaines souches ne répondent pas au farnésol et nous avons vérifié les hypothèses que : 1) la proportion des Non-Répondeurs (NR) au farnésol est similaire entre les souches de provenance orale et vaginale; 2) la capacité de formation de biofilm varie d’une souche à une autre mais les Non-Répondeurs en produisent en plus grande quantité; 3) la technique RAPD-PCR permettra de regrouper les souches de cette levure suivant leur provenance, leur capacité de formation de biofilm et leur aptitude à répondre au farnésol. La découverte d’une souche vaginale Non-Répondeur nous permet de croire que la proportion de ces souches est similaire entre les deux types de provenance. Les souches caractérisées Non-Répondeurs produisent 30 % plus de biofilm que les Répondeurs en absence de farnésol exogène dans le milieu. En présence de farnésol exogène, les Non-Répondeurs produisent 70 % plus de biomasse que les Répondeurs. De plus, la technique RAPD ne nous a pas permis de classer nos souches d’après les caractéristiques proposées. En conclusion, les souches orales de C. albicans semblent produire en moyenne plus de biomasse que les souches vaginales. Aussi, les NR semblent moins affectés par la présence du farnésol, ce qui pourrait causer la présence de biofilms tenaces. Les amorces utilisées pour la technique RAPD n’ont pas été efficace à la classification des souches dépendamment de leur provenance, de leur capacité à former un biofilm et à répondre au farnésol. Mots clés : Candida albicans, biofilm, perception du quorum (quorum sensing), farnésol, Non-Répondeur