4B.05: Plasma Lasma copeptin is associated with insulin resistance in a Swiss population-based study

OBJECTIVE: Previous studies suggest that arginine vasopressin may have a role in metabolic syndrome (MetS) and diabetes by altering liver glycogenolysis, insulin, and glucagon secretion and pituitary ACTH release. We tested whether plasma copeptin, the stable C-terminal fragment of arginine vasopressin prohormone, was associated with insulin resistance and MetS in a Swiss population-based study. DESIGN AND METHOD: We analyzed data from the population-based Swiss Kidney Project on Genes in Hypertension. Copeptin was assessed by an immunoluminometric assay. Insulin resistance was derived from the HOMA model and calculated as follows: (FPI x FPG)/22.5, where FPI is fasting plasma insulin concentration (mU/L) and FPG fasting plasma glucose (mmol/L). Subjects were classified as having the MetS according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Mixed multivariate linear regression models were built to explore the association of insulin resistance with copeptin. In addition, multivariate logistic regression models were built to explore the association between MetS and copeptin. In the two analyses, adjustment was done for age, gender, center, tobacco and alcohol consumption, socioeconomic status, physical activity, intake of fruits and vegetables and 24 h urine flow rate. Copeptin was log-transformed for the analyses. RESULTS: Among the 1,089 subjects included in this analysis, 47% were male. Mean (SD) age and body mass index were 47.4 (17.6) years 25.0 (4.5) kg/m2. The prevalence of MetS was 10.5%. HOMA-IR was higher in men (median 1.3, IQR 0.7-2.1) than in women (median 1.0, IQR 0.5-1.6,P < 0.0001). Plasma copeptin was higher in men (median 5.2, IQR 3.7-7.8 pmol/L) than in women (median 3.0, IQR 2.2-4.3 pmol/L), P < 0.0001. HOMA-IR was positively associated with log-copeptin after full adjustment (β (95% CI) 0.19 (0.09-0.29), P < 0.001). MetS was not associated with copeptin after full adjustment (P = 0.92). CONCLUSIONS: Insulin resistance, but not MetS, was associated with higher copeptin levels. Further studies should examine whether modifying pharmacologically the arginine vasopressin system might improve insulin resistance, thereby providing insight into the causal nature of this association.

Determinantes internos y externos en el proceso de aprendizaje. Una aproximación al caso español a partir de la ECV-05

El principal objetivo del trabajo es determinar el grado de influencia de los diferentes factores individuales y del entorno, familiar y social, en la capacidad de los individuos para alcanzar o no ciertos objetivos educativos, teniendo en cuenta los efectos posteriores de aquellos en relación con su inserción en el mercado de trabajo, su nivel salarial y su productividad (Card, 1999). Para ello, se ha aplicado un método de estimación de máxima verosimilitud, mediante la utilización de un logit ordenado, empleando el modulo especial de 2007 de la Encuesta de Condiciones de Vida de EUROSTAT dedicado a la transmisión intergeneracional de la pobreza. Esta base de datos cuenta con valiosa información acerca del individuo y la situación personal y familiar de éste cuando tenía entre 12 y 16 años, resultando representativa para las Comunidades Autónomas españolas y para la población inmigrante. Los resultados obtenidos, que van en la línea de la literatura empírica analizada; indican la relevancia del género, del estado de salud y del lugar de nacimiento, en cuanto a las variables referidas directamente al individuo y, en relación al resto de las variables utilizadas; destaca la importancia de la educación y el tipo de ocupación de los padres, de la estructura familiar y de la situación financiera existente en el momento en que el individuo se estaba educando

Theses philosophicae (1822-10-05)

Painovuosi nimekkeestä.

Theses (1819-05-08)

Käsikirjoitus. Julkaisua ei mahdollisesti lainkaan painettu.

Theses philosophicae (1760-05-19)

Invokaatio: Q.F.F.Q.S.

Aphorismi miscellanei (1762-05-27)

Invokaatio: D.D.

Theses miscellaneae (1757-05-21)

Invokaatio: Deo duce.

Portraits de femmes : publication artistique bimensuelle / [texte signé : Émile Henriot]

1910/05 (N10,Madame du Barry).

Portraits de femmes : publication artistique bimensuelle / [texte signé : Émile Henriot]

1911/05 (N29,Charlotte Corday).

Portraits de femmes : publication artistique bimensuelle / [texte signé : Émile Henriot]

1911/05 (N30,Mlle Duthé).