Relatorio - AB COMPUTERS

Atualmente os computadores são objetos indispensáveis na vida das pessoas, possibilitando que os utilizadores tenham uma vida mais simplificada quanto ao nível profissional e pessoal. Eles vieram para revolucionar a forma como os indivíduos, estudantes e empresas trabalham, vivem, se comunicam, educam, partilham informações e se entretêm. Os computadores hoje em dia são partes globais de virtualidade de muitas atividades humanas e não humanas possíveis. E é neste âmbito, considerando esta globalização, que fundou-se a AB Computers. Esta empresa não se encontra no mercado para ser mais uma, mas sim para revolucionar o mercado dos computadores. E é com este objetivo que a empresa mantem-se no mercado fabricando computadores de altíssima qualidade, mantem uma estreita relação com os clientes, pensa na melhor adequação entre custos e benefícios e coloca o seu produto nas regiões mais próximas dos seus clientes. Mas é com este propósito também, que a empresa preocupa-se com o bem-estar, motivação, capacitação e disciplina dos seus colaboradores, oferecendo formações e incentivos para que melhor desempenhem as suas funções. No presente Relatório, será possível avaliar o desempenho da atuação da empresa no mercado de computadores durante estes oito trimestres de atividade (2 anos). Considerar-se-ão pontos como a situação financeira, a análise do desempenho de marketing, uma análise crítica do plano de marketing anteriormente elaborado, a avaliação da estratégia e do desempenho da empresa, a avaliação da situação atual da empresa e do mercado e, as estratégias que serão utilizadas para que a empresa possa enfrentar os novos desafios a que se propôs. Estratégias essas, que auxiliarão a empresa para que esta continue sendo a líder do mercado.

Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab')2: a possible implication for mucosal defense.

Secretory component (SC) represents the soluble ectodomain of the polymeric Ig receptor, a membrane protein that transports mucosal Abs across epithelial cells. In the protease-rich environment of the intestine, SC is thought to stabilize the associated IgA by unestablished molecular mechanisms. To address this question, we reconstituted SC-IgA complexes in vitro by incubating dimeric IgA (IgAd) with either recombinant human SC (rSC) or SC isolated from human colostral milk (SCm). Both complexes exhibited an identical degree of covalency when exposed to redox agents, peptidyl disulfide isomerase, and temperature changes. In cross-competition experiments, 50% inhibition of binding to IgAd was achieved at approximately 10 nM SC competitor. Western blot analysis of IgAd digested with intestinal washes indicated that the alpha-chain in IgAd was primarily split into a 40-kDa species, a phenomenon delayed in rSC- or SCm-IgAd complexes. In the same assay, either of the SCs was resistant to degradation only if complexed with IgAd. In contrast, the kappa light chain was not digested at all, suggesting that the F(ab')2 region was left intact. Accordingly, IgAd and SC-IgAd digestion products retained functionality as indicated by Ag reactivity in ELISA. Size exclusion chromatography under native conditions of digested IgAd and rSC-IgAd demonstrates that SC exerts its protective role in secretory IgA by delaying cleavage in the hinge/Fc region of the alpha-chain, not by holding together degraded fragments. The function of integral secretory IgA and F(ab')2 is discussed in terms of mucosal immune defenses.

Bone marrow dosimetry in rats using direct tissue counting after injection of radio-iodinated intact monoclonal antibodies or F(ab')2 fragments.

Normal rats were injected intravenously with 131I- and 125I-labeled intact murine and chimeric mouse-human monoclonal antibodies directed against carcinoembryonic antigen or with the corresponding F(ab')2 fragments. At different times after injection, individual animals were killed and radioactivity of blood and major organs, including bones and bone marrow, was determined. Ratios comparing radioactivity concentration in different tissues with that of bone marrow were calculated and found to remain stable during several effective half-lives of the antibodies. Mean bone marrow radioactivity was 35% (range, 29%-40%) of that of blood and 126% (range, 108%-147%) of that of liver after injection of intact Mabs or F(ab')2 fragments. In nude rats bearing human colon carcinoma xenografts producing carcinoembryonic antigen, relative bone marrow radioactivity was slightly lower than that in normal rats.

Ex XIIII. T. Livii Decadibus. Prima, tertia, quarta, in qua praeter fragmenta III, & X libri, quae in Germania nuper reperta, hic etiam continentur, multa adulterina expunximus, multa vera recepimus, quae in aliis non habentur. Epitome singulorum librorum XIIII Decadum. Historia omnium XIIII Decadum in compendium redacta ab L. Floro. Polybii lib. V de rebus Romanis latinitate donati à Nicolao Perotto. Index copiosissimus rerum omnium memorabilium...

[Histoire romaine (latin). 1518-1533]

Ex XIIII. T. Livii Decadibus. Prima, tertia, quarta, in qua praeter fragmenta III, & X libri, quae in Germania nuper reperta, hic etiam continentur, multa adulterina expunximus, multa vera recepimus, quae in aliis non habentur. Epitome singulorum librorum XIIII Decadum. Historia omnium XIIII Decadum in compendium redacta ab L. Floro. Polybii lib. V de rebus Romanis latinitate donati à Nicolao Perotto. Index copiosissimus rerum omnium memorabilium...

[Histoire romaine (latin). 1518-1533]

Reliure de : Blondi Flavii Forliviensis historiarum ab inclinatione Romanorum libri XXXI... - "A la fin" : Basileae, in officina Frobeniana per Hieronymum Frobenium, Ioannem Hervagium et Nicolaum Episcopium. Anno MDXXXI mense Martio

Numérisation partielle de reliure

Reliure de : De Romanorum militia et castrorum metatione liber... ex Polybii historiis per A. Janum Lascarem,... excerptus, et ab eodem latinitate donatus, ipso etiam graeco libro, ut omnia conferri possint... adjuncto. Ejusdem A. Jani Lascaris Epigrammata et graeca et latina... Item Jacobi, comitis Purliliarum de re militari lib. II. Ad aetatis nostrae bellandi rationem... necessarii. [Edidit Jo Oporinus.]

Numérisation partielle de reliure

M. Tullii Ciceronis opera, omnium quae hactenus excusa sunt castigatissima, nunc primum in lucem edita (a Petro Victorio). Secundus tomus M. T. Ciceronis orationes habet, ab Andrea Naugerio, in suam integritatem restitutas

Comprend : Explicationes suarum in Ciceronem castigationum

Ab initio study of NOx compounds adsorption on SnO2 surface

An ab initio study of the adsorption processes on NOx compounds on (1 1 0) SnO2 surface is presented with the aim of providing theoretical hints for the development of improved NOx gas sensors. From first principles calculations (DFT¿GGA approximation), the most relevant NO and NO2 adsorption processes are analyzed by means of the estimation of their adsorption energies. The resulting values and the developed model are also corroborated with experimental desorption temperatures for NO and NO2, allowing us to explain the temperature-programmed desorption experiments. The interference of the SO2 poisoning agent on the studied processes is discussed and the adsorption site blocking consequences on sensing response are analyzed.