Interpolatory methods for model reduction of large-scale dynamical systems

Magdeburg, Univ., Fak. für Mathematik, Diss., 2013

Analysis and numerical investigation of dynamic models for liquid chromatography

Magdeburg, Univ., Fak. für Mathematik, Diss., 2013

Analytical and numerical investigation of the ultra-relativistic Euler equations

Magdeburg, Univ., Fak. für Mathematik, Diss., 2013

Numerisches Lösen grosser dünnbesetzter Matrixgleichungen in Python

Magdeburg, Univ., Fak. für Mathematik, Bachelorarbeit, 2013

Higher order finite elements and the fictitious domain concept for wave propagation analysis

Magdeburg, Univ., Fak. für Maschinenbau, Diss., 2014

Algorithm engineering for expression dag based number types

Magdeburg, Univ., Fak. für Informatik, Diss., 2015

Computational methods for model reduction of large-scale sparse structured descriptor systems

Magdeburg, Univ., Fak. für Mathematik, Diss., 2015

Bilinear H 2-optimal Model Order-Reduction with applications to thermal parametric systems

Magdeburg, Univ., Fak. für Mathematik, Diss., 2015

Stability and error analysis for a numerical scheme to approximate elastic flow

Otto-von-Guericke-Universität Magdeburg, Fakultät für Mathematik, Univ., Dissertation, 2015

Zeitbereichs-Modellreduktion und Sylvester-Gleichungen

Otto-von Guericke-Universität Magdeburg, Fakultät für Mathematik, Masterarbeit, 2015

On the choice of an exchange rate regime: target zones revisited

From the classical gold standard up to the current ERM2 arrangement of the European Union, target zones have been a widely used exchange regime in contemporary history. This paper presents a benchmark model that rationalizes the choice of target zones over the rest of regimes: the fixed rate, the free float and the managed float. It is shown that the monetary authority may gain efficiency by reducing volatility of both the exchange rate and the interest rate at the same time. Furthermore, the model is consistent with some known stylized facts in the empirical literature that previous models were not able to produce, namely, the positive relation between the exchange rate and the interest rate differential, the degree of non-linearity of the function linking the exchage rate to fundamentals and the shape of the exchange rate stochastic distribution.

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Philosophie der Physik

Inhalt: Seit ihren Anfängen bei den Vorsokratikern sind Philosophie und Physik eng miteinander verbunden. Kappt man diese Verbindung, gibt man die Kernaufgabe der Physik - zu Wissen über die Natur zu gelangen - ebenso auf wie die der Philosophie, die grundlegenden Charakteristika der Welt zu erforschen. Dieser Band soll die Vielfalt und Lebendigkeit der philosophischen Auseinandersetzung mit der Physik im deutschsprachigen Raum heute aufzeigen. Er setzt den Schwerpunkt auf die Interpretation der fundamentalen physikalischen Theorien, also die Quantentheorie und die allgemeine Relativitätstheorie, einschließlich der Quantengravitation und der Quantenfeldtheorie.

Pharmacokinetic interaction between methotrexate and chloral hydrate.

We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high-dose chemotherapy when co-administered with CH despite normal renal function, adequate hydration, and alkalinization. Mean MTX area under the curve associated with CH administration was 1,134 µmol hours/L, compared to 608 µmol hours/L after discontinuation of CH. This interaction possibly resulted from a competition between anionic CH metabolites and MTX for renal tubular excretion.