Le dictionnaire des arts et des sciences. Tome 1 / par M. D. C...

Collection : Archives de la linguistique française ; 91

Le grand dictionnaire françois-latin : augmenté en cette édition... spécialement des mots de marine, venerie, et faulconnerie... ([Reprod.]) / recueilli des observations de plusieurs hommes doctes, entre autres de M. Nicod,... ; par M. P. de Brosses,...

Collection : Archives de la linguistique française ; 61

Le thresor des trois langues, espagnole, françoise, et italienne : auquel est contenuë l'explication de toutes les trois, respectivement l'une par l'autre... ([Reprod.]) / par Caesar Oudin, Nicot, La Crusca, et autres

Collection : Archives de la linguistique française ; 308

Thomas Corneille grammairien... ([Reprod.]) / par Gilbert Sautebin...

Collection : Archives de la linguistique française ; 362

La logique ou L'art de penser : contenant outre les règles communes, plusieurs observations nouvelles propres à former le jugement ([Reprod.])

Collection : Archives de la linguistique française ; 15

La logique ou L'art de penser / Antoine Arnauld, Pierre Nicole ; notes et postf. de Charles Jourdain

Collection : Collection Tel ; 211

Endothelial, but not smooth muscle, peroxisome proliferator-activated receptor β/δ regulates vascular permeability and anaphylaxis.

BACKGROUND: Remodeling of quiescent vessels with increases in permeability, vasodilatation, and edema are hallmarks of inflammatory disorders. Factors involved in this type of remodeling represent potential therapeutic targets. OBJECTIVES: We investigated whether the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR) β/δ, a regulator of metabolism, fibrosis, and skin homeostasis, is involved in regulation of this type of remodeling. METHODS: Wild-type and various Pparb/d mutant mice were used to monitor dermal acute vascular hyperpermeability (AVH) and passive systemic anaphylaxis-induced hypothermia and edema. PPARβ/δ-dependent kinase activation and remodeling of endothelial cell-cell junctions were addressed by using human endothelial cells. RESULTS: AVH and dilatation of dermal microvessels stimulated by vascular endothelial growth factor A, histamine, and thrombin are severely compromised in PPARβ/δ-deficient mice. Selective deletion of the Pparb/d-encoding gene in endothelial cells in vivo similarly limits dermal AVH and vasodilatation, providing evidence that endothelial PPARβ/δ is the major player in regulating acute dermal microvessel remodeling. Furthermore, endothelial PPARβ/δ regulatory functions are not restricted to the skin vasculature because its deletion in the endothelium, but not in smooth muscle cells, also leads to reduced systemic anaphylaxis, the most severe form of allergic reaction, in which an acute vascular response plays a key role. PPARβ/δ-dependent AVH activation likely involves the activation of mitogen-activated protein kinase and Akt pathways and leads to downstream destabilization of endothelial cell-cell junctions. CONCLUSION: These results unveil not only a novel function of PPARβ/δ as a direct regulator of acute vessel permeability and dilatation but also provide evidence that antagonizing PPARβ/δ represents an important strategy to consider for moderating diseases with altered endothelial integrity, such as acute inflammatory and allergic disorders.

Guercino (1591-1666). Capolavori da Cento e da Roma

Un dels molts actes amb què la ciutat de Roma ha celebrat els 150 anys de la unificació d"Itàlia (1861˗2011) ha estat la presentació oficial del complex i acurat procés de restauració del Palazzo Barberini (1625˗1633). Restauració de l"edifici i, alhora, reestructuració de l"espai expositiu i del discurs museogràfic de la Galleria Nazionale di Arte Antica, dirigit tot per Rossella Vodret, reconeguda historiadora de l"art i Soprintendente per il Patrimonio Storico Artistico e del Polo Museale di Roma.

Theses miscellaneae

Invocatio: Deo duce.

L'Univers

1871/11/27 (Numéro 1625).

Svecia et Norvegia etc.

Janamittakaava: Miliaria Germanica.

Le Petit journal illustré

1922/02/12 (Numéro 1625).