Neuroimaging findings in cryptogenic stroke patients with and without patent foramen ovale

BACKGROUND AND PURPOSE Patent foramen ovale (PFO) and cryptogenic stroke are commonly associated but some PFOs are incidental. Specific radiological findings associated with PFO may be more likely to indicate a PFO-related cause. We examined whether specific radiological findings are associated with PFO among subjects with cryptogenic stroke and known PFO status. METHODS We analyzed the Risk of Paradoxical Embolism(RoPE) Study database of subjects with cryptogenic stroke and known PFO status, for associations between PFO and: (1) index stroke seen on imaging, (2) index stroke size, (3) index stroke location, (4) multiple index strokes, and (5) prior stroke on baseline imaging. We also compared imaging with purported high-risk echocardiographic features. RESULTS Subjects (N=2680) were significantly more likely to have a PFO if their index stroke was large (odds ratio [OR], 1.36; P=0.0025), seen on index imaging (OR, 1.53; P=0.003), and superficially located (OR, 1.54; P<0.0001). A prior stroke on baseline imaging was associated with not having a PFO (OR, 0.66; P<0.0001). Finding multiple index strokes was unrelated to PFO status (OR, 1.21; P=0.161). No echocardiographic variables were related to PFO status. CONCLUSIONS This is the largest study to report the radiological characteristics of patients with cryptogenic stroke and known PFO status. Strokes that were large, radiologically apparent, superficially located, or unassociated with prior radiological infarcts were more likely to be PFO-associated than were unapparent, smaller, or deep strokes, and those accompanied by chronic infarcts. There was no association between PFO and multiple acute strokes nor between specific echocardiographic PFO features with neuroimaging findings.

Ms. lat. qu. 112 - Politische, satirische und militärische Schriften

Die Foliierung geht nur bis Bl. 552; zusätzlich gibt es die Blätter 229a, 319a, 488a und 508a; das Blatt 373 wurde bei der Foliierung übersprungen.

Ms. hebr. oct. 112 - Perush ha-Ran

Vorbesitzer: Abraham Merzbacher

Ms. Barth. 112 - Commentarii in Ciceronis Topica

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Kritische Beleuchtung einer interessanten Talmudstelle : (b. Kethubot 112 a b. j. Schebiith. 35 c)

Wilhelm Bacher

Kritische Beleuchtung einer interessanten Talmudstelle : (b. Kethubot 112 a b. j. Schebiith 35 c)

Wilhelm Bacher

Ms. germ. qu. 112 - Willehalm von Orlens

Vorbesitzer: Simon von Stöffeln; Kloster Bronnbach; Kloster Neustadt a. M.; Fürstlich Löwenstein-Rosenbergische Hofbibliothek Klein-Heubach; Freiherrlich Carl von Rothschild'sche Bibliothek Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 680 - Mitteilung über die Bankgeschäfte mit dem Bankhaus Muhl

u.a.: Vorschläge Johanna Schopenhauers über die Aufteilung der Erbschaft;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 112 - Einschätzung über die Bevölkerung von Allermöhe

u.a.: Besuchsankündigung in Hamburg; Willings;

Ms. Praed. 112 - Additiones in orationem de concordia curatorum et mendicantium praetitulatam

Vorbesitzer: Dominikanerkloster Frankfurt am Main