Distribución y abundancia relativa de cetáceos durante el crucero de BIC Humboldt 9709-10, de Matarani a Paita

Información obtenida a partir de los avistajes de cetáceos efectuados durante el Crucero BIC Humboldt 9709-10 realizado entre Matarani (17°26 ' S) y Paita (04°54 ' S), hasta una distancia máxima de 100 mn de la costa, del 1 de setiembre al 11 de octubre 1997. En un total de 150,8 h y 1512,53 mn de observación, se realizaron 97 avistajes de cetáceos, 71% de odontocetos; 27% de misticetos.

Condiciones oceanográficas y ondas Kelvin en primavera 2004: crucero BIC Olaya 0409-10

Este crucero oceanográfico 0409-10, se realizó entre el 24 setiembre y 7 octubre 2004; abarcó el área entre Punta Caballas (15°S) y Paita (5°S), hasta 190 mn de la costa. El objetivo era conocer las características del ambiente marino y establecer sus relaciones con un probable evento cálido. Las observaciones más importantes fueron: (1) ondas Kelvin, ya registradas en el invierno, motivaron proyección de aguas ecuatoriales superficiales hacia el sur y suroeste, entre los 5-7,5°S, provocando condiciones ligeramente cálidas en la zona oceánica, con un pequeño núcleo de anomalía térmica de +2,3 °C en la zona costera de Paita; (2) al sur de los 6°S (Punta La Negra) dentro de las 100 mn hubo anomalías térmicas próximas a lo normal; (3) el afloramiento costero se desarrolló moderadamente en el área de estudio en una franja de 10 a 25 mn de la costa, excepto en la zona frente a Paita; (4) las aguas subtropicales superficiales (ASS) se ubicaron fuera de las 50 mn entre 9-12°S, por fuera de las 160 mn al norte de esa latitud y a 25 mn de Pucusana, alcanzando 90 m de profundidad frente a Chimbote; (5) la isoterma de 15 °C se registró entre 11 a 100 m, con mayor profundidad frente a Chimbote, por fuera de 100 mn, mostrando que los flujos predominantes provinieron del sur; (6) la Extensión Sur de la Corriente de Cromwell (ESCC) mostró profundización de la isoterma de 14 °C y no con la de 15 °C como es normal; (7) vientos predominantes del SE con 4 a 7 m/s fueron característicos durante el crucero, excepto frente a Paita, Chicama y de regreso al Callao donde se registraron velocidades entre 7 a 11 m/s.

IL28B polymorphisms, IP-10 and viral load predict virological response to therapy in chronic hepatitis C.

Aliment Pharmacol Ther 2011; 33: 1162-1172 SUMMARY: Background  Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma and the identification of the predictors of response to antiviral therapy is an important clinical issue. Aim  To determine the independent contribution of factors including IL28B polymorphisms, IFN-gamma inducible protein-10 (IP-10) levels and the homeostasis model assessment of insulin resistance (HOMA-IR) score in predicting response to therapy in chronic hepatitis C (CHC). Methods  Multivariate analysis of factors predicting rapid (RVR) and sustained (SVR) virological response in 280 consecutive, treatment-naive CHC patients treated with peginterferon alpha and ribavirin in a prospective multicentre study. Results  Independent predictors of RVR were HCV RNA <400 000 IU/mL (OR 11.37; 95% CI 3.03-42.6), rs12980275 AA (OR 7.09; 1.97-25.56) and IP-10 (OR 0.04; 0.003-0.56) in HCV genotype 1 patients and lower baseline γ-glutamyl-transferase levels (OR = 0.02; 0.0009-0.31) in HCV genotype 3 patients. Independent predictors of SVR were rs12980275 AA (OR 9.68; 3.44-27.18), age <40 years (OR = 4.79; 1.50-15.34) and HCV RNA <400 000 IU/mL (OR 2.74; 1.03-7.27) in HCV genotype 1 patients and rs12980275 AA (OR = 6.26; 1.98-19.74) and age <40 years (OR 5.37; 1.54-18.75) in the 88 HCV genotype 1 patients without a RVR. RVR was by itself predictive of SVR in HCV genotype 1 patients (OR 33.0; 4.06-268.32) and the only independent predictor of SVR in HCV genotype 2 (OR 9.0, 1.72-46.99) or genotype 3 patients (OR 7.8, 1.43-42.67). Conclusions  In HCV genotype 1 patients, IL28B polymorphisms, HCV RNA load and IP-10 independently predict RVR. The combination of IL28B polymorphisms, HCV RNA level and age may yield more accurate pre-treatment prediction of SVR. HOMA-IR score is not associated with viral response.

Euroopan yhteisöjen tuomioistuimen tuomio 1.6.1999 asiassa C-126/97 (Eco Swiss China Time)

Kilpailu - Välimiesoikeuden velvollisuus soveltaa omasta aloitteestaan 81 EY artiklaa (aiemmin 85 artiklaa) - 81 EY artiklan ordre public -luonne - Kansallisen tuomioistuimen velvollisuus kumota välitystuomio

Vibratory Effects in Reinforced Portland Cement Concrete Pavement, MLR-97-2, 1997

A double mat of reinforcement steel consisting of No. 5 bars was placed in the longitudinal and transverse directions in a 26' wide, 10" thick pavement. The bars were placed on 12" centers with 2" of cover from the top and bottom surfaces. The special reinforcement is to provide additional strength in the pavement over an area of old coal mine tunnels. Auxiliary and standard paver vibrators were used to consolidate the concrete. There was concern that over-vibration could be occurring in some areas and also that a lack of consolidation may be occurring under the steel bars in some areas. A core evaluation study of the pavement was developed. The results showed that the consolidation and the air contents were satisfactory. Additional paving with reinforcement in the same area should use the same or similar method and amount of vibration as was used in the area evaluated in this study.

Field Evaluation of Quality Management Concrete, MLR-97-3, 1998

Quality management concrete allows the contractor to develop the mix design for the portland cement concrete. This research was initiated to gain knowledge about contractor mix designs. An experiment was done to determine the variation in cylinders, beams, and cores that could be used to test the strength of the contractor's mix. In addition, the contractor's cylinder strengths and gradations were analyzed for statistical stability and process capability. This research supports the following conclusions: (1) The mold type used to cast the concrete cylinders had an effect on the compressive strength of the concrete. The 4.5-in. by 9-in. (11.43-cm by 22.86-cm) cylinders had lower strength at a 95% confidence interval than the 4-in. by 8-in. (10.16-cm by 20.32-cm) and 6-in. by 12-in. (15.24-cm by 30.48-cm) cylinders. (2) The low vibration consolidation effort had the lowest strength of the three consolidation efforts. In particular, an interaction occurred between the low vibration effort and the 4.5-in. by 9-in. (11.43-cm by 22.86-cm) mold. This interaction produced very low compressive strengths when compared with the other consolidation efforts. (3) A correlation of 0.64 R-squared was found between the 28 day cylinder and 28 day compressive strengths. (4) The compressive strength results of the process control testing were not in statistical control. The aggregate gradations were mostly in statistical control. The gradation process was capable of meeting specification requirements. However, many of the sieves were off target. (5) The fineness modulus of the aggregate gradations did not correlate well with the strength of the concrete. However, this is not surprising considering that the gradation tests and the strength tests did not represent the same material. In addition, the concrete still has many other variables that will affect its strength that were not controlled.

New Method for Breaking High Strength Prestress Cable, MLR-97-6, 1997

A new method was developed for breaking high strength prestressed cable. The old method used an aluminum oxide grit packed into a special gripping jaw. The new method uses aluminum shims wrapped around the cable and then is gripped with a V-grip. The new method gives nearly 100% "good breaks" on the cable compared to approximately 10% good breaks with the old method. In addition, the new cable breaking method gives higher ultimate tensile strengths, is more reproducible, is quicker, cleaner and easier on equipment.

New Method for Breaking High Strength Prestress Cable, MLR-97-6, 1997

A new method was developed for breaking high strength prestressed cable. The old method used an aluminum oxide grit packed into a special gripping jaw. The new method uses aluminum shims wrapped around the cable and then is gripped with a V-grip. The new method gives nearly 100% "good breaks" on the cable compared to approximately 10% good breaks with the old method. In addition, the new cable breaking method gives higher ultimate tensile strengths, is more reproducible, is quicker, cleaner and easier on equipment.

Is chemotherapy necessary for premenopausal women with lower-risk node-positive, endocrine responsive breast cancer? 10-year update of International Breast Cancer Study Group Trial 11-93.

INTRODUCTION: International Breast Cancer Study Group (IBCSG) Trial 11-93 is the largest trial evaluating the role of the addition of chemotherapy to ovarian function suppression/ablation (OFS) and tamoxifen in premenopausal patients with endocrine-responsive early breast cancer. METHODS: IBCSG Trial 11-93 is a randomized trial comparing four cycles of adjuvant chemotherapy (AC: doxorubicin or epirubicin, plus cyclophosphamide) added to OFS and 5 years of tamoxifen versus OFS and tamoxifen without chemotherapy in premenopausal patients with node-positive, endocrine-responsive early breast cancer. There were 174 patients randomized from May 1993 to November 1998. The trial was closed before the target accrual was reached due to low accrual rate. RESULTS: Patients randomized tended to have lower risk node-positive disease and the median age was 45. After 10 years median follow up, there remains no difference between the two randomized treatment groups for disease-free (hazard ratio=1.02 (0.57-1.83); P=0.94) or overall survival (hazard ratio=0.97 (0.44-2.16); P=0.94). CONCLUSION: This trial, although small, offers no evidence that AC chemotherapy provides additional disease control for premenopausal patients with lower-risk node-positive endocrine-responsive breast cancer who receive adequate adjuvant endocrine therapy. A large trial is needed to determine whether chemotherapy adds benefit to endocrine therapy for this population.