Anais do Parlamento Brasileiro : índice de maio de 1828 : Tomo I

Câmara dos Srs. Deputados . Quarto (4º) Ano da Primeira (1ª) Legislatura.

Anais do Parlamento Brasileiro : índice de maio de 1829 : Tomo II

Organizados por Antônio Pereira Pinto.

Anais do Parlamento Brasileiro : índice de março a maio de 1843 : Tomo II

Reunidos por Antônio Henoch dos Reis, em virtude da resolução da Mesa da Câmara.

Anais do Parlamento Brasileiro : índice de março a maio de 1913 : Tomo II

Convocação Extraordinária de 2 de Abril de 1913.

Melhoria da Atenção à Saúde das Crianças de Zero a 72 Meses de Idade, UBS 1, Porto Walter, AC.

A Saúde da Criança foi a primeira ação programática estabelecida na atenção primária à saúde e foi um fator importante na redução de mortalidade infantil no Brasil o desenvolvimento e crescimento das crianças requer atenção especial no que respeita a assistência em saúde sobre tudo na atuação de profissionais da área da medicina, enfermagem e odontologia que compõem a ESF. Depois de identificar em minha UBS que a cobertura para saúde da criança era baixa, onde as ações de puericultura estabelecidas pelo Ministério da Saúde não eram realizadas, não se agendavam consultas porque a demanda de usuários era muito grande porque só existia a nossa UBS, foi realizada uma intervenção de saúde com o objetivo de melhorar a Atenção na Saúde da Criança de zero a setenta e dois meses, na UBS #1 Porto Walter /AC no período de março a maio do 2015. Esta UBS,esta composta por uma equipe de saúde, minha área de abrangência é de 2.019 habitantes, distribuída em 5 micro áreas. De 100 crianças entre zero e 72 meses residentes na área de abrangência 81 foram acompanhadas durante os três meses da intervenção, alcançando uma cobertura de 80,2%. Este resultado foi produto do trabalho realizado por toda a equipe, o apoio do gestor de saúde em quanto a disponibilização do material necessários, também contamos com o apoio das lideranças comunitárias na divulgação da implementação da ação programática, outros resultados significantes foi na melhoria da qualidade do atendimento, por exemplo, aumentou o número de consultas na primeira semana de vida chegando a 44,4% assim como o monitoramento do crescimento oi de (93,8%)monitorando o 100% de crianças com déficit e excesso de peso para obter estes resultados foi de suma importância o material garantido por o gestora de saúde, aumento o numero de crianças com vacinação em dia de alcançando 84% ,o número de crianças com teste de pezinho realizado também aumento chegando ao 70,4%, o atendimento odontológico o primeiro e segundo mês foi zero ,mais ao final da intervenção o seja no terceiro mês alcançou se 47,1 %.Para a comunidade a intervenção foi de muita importância porque as mães demonstram satisfação com a prioridade no atendimento, já estão conscientizadas sobre a importância da ação programática que antes não era realizada na UBS, alem de que tem melhor conhecimento em o processo de desarrolho de seus filhos ,como evitar os acidentes , prevenção de doenças qual é a melhor nutrição o seja melhora da qualidade de vida das crianças .Para o serviço teve importância também porque antes as atividades de atenção a crianças eram concentradas só a atenção médica. A intervenção reviu as atribuições da equipe viabilizando o atendimento a um maior número de crianças na área de abrangência. A melhoria do registro e o agendamento das crianças para consultas viabilizou a otimização da agenda para a atenção e à demanda espontânea alem de que motivou a equipe a trabalhar em conjunto.

Melhoría da Atenção á Saúde dos Hipertensos e Diabéticos na UBS Móvel Piratini 1 Piratini/RS

Resumo JAEN, Jorge Luis Bejerano. Melhoria da Atenção à Saúde dos Hipertensos e/ou Diabéticos na UBS Móvel Piratini 1, Piratini/RS. 2015. 68f. (Curso de Especialização em Saúde da Família) - Departamento de Medicina Social, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, 2015. A Hipertensão Arterial e Diabetes Mellitus são causas de morte, sendo consideradas como problema de saúde em todo o Brasil. A Unidade Básica de Saúde Piratini 1 é uma unidade móvel que se desloca por todo o município, sendo que o número estimado da população adstrita à Unidade é de aproximadamente 8000 pessoas, estimando 920 hipertensos e 245 diabéticos. O presente trabalho teve como objetivo melhorar a atenção à saúde dos usuários hipertensos e diabéticos na UBS. A intervenção foi realizada na unidade por um período de doze semanas, de fevereiro até maio 2015, em que foram realizadas várias ações estruturadas dentro de quatro eixos temáticos, “Monitoramento e Avaliação”, “Organização e Gestão do Serviço”, “Engajamento Público” e “Qualificação da Prática Clínica. A cobertura antes da intervenção era de 10 usuários hipertensos, correspondendo a 1,1% da estimativa e de 35 diabéticos, correspondendo a 14,2% dos estimados. Durante a intervenção foram cadastrados 41% dos hipertensos estimados, que equivaleram a 377 pessoas e 49% dos diabéticos estimados cadastrados, que equivaleram a 120 pessoas. A intervenção serviu para o cadastramento dos hipertensos e diabéticos, o atendimento foi planejado e agendado e a intervenção foi incorporada a rotina de trabalho da unidade móvel. Foram realizadas várias capacitações desde o início da intervenção, tendo em conta o cronograma onde foram abordados temas de promoção e prevenção de saúde e todo o referente ao protocolo das duas doenças. Palavras-chave: Atenção primária à saúde. Saúde da família. Doença Crônica. Diabetes Mellitus. Hipertensão.

Up-regulation Of Dnam-1 And Nkp30, Associated With Improvement Of Nk Cells Activation After Long-term Culture Of Mononuclear Cells From Patients With Ovarian Neoplasia.

This study aimed at evaluating the functional activation and activating receptors expression on resting, short- and long-term NK and NK-like T cells from blood of ovarian neoplasia patients. Blood from patients with adnexal benign alterations (n = 10) and ovarian cancer (grade I-IV n = 14) were collected after signed consent. Effector cells activation was evaluated by the expression of the CD107a molecule. Short-term culture was conducted overnight with IL-2 and long-term culture for 21 days, by a method designed to expand CD56(+) lymphocytes. Short-term culture significantly increased NK cells activation compared to resting NK cells (p<0.05), however, the long-term procedure supported an even higher increase (p<0.001). Resting NK-like T cells showed poor activation, which was not altered by the culture procedures. The long-term culture effectively increased the expression of the activating receptors on NK and NK-like T cells, either by increasing the number of cells expressing a given receptor and/or by up-regulating their expression intensity. As a conclusion, the long-term culture system employed, resulted in a high number of functional NK cells. The culture system was particularly efficient on the up-regulation of NKp30 and DNAM-1 receptors on NK cells.

Hypertrophic Adenoid Is A Major Infection Site Of Human Bocavirus 1.

Human bocavirus 1 (HBoV1) is associated with respiratory infections worldwide, mainly in children. Similar to other parvoviruses, it is believed that HBoV1 can persist for long periods of time in humans, probably through maintaining concatemers of the virus single-stranded DNA genome in the nuclei of infected cells. Recently, HBoV-1 was detected in high rates in adenoid and palatine tonsils samples from patients with chronic adenotonsillar diseases, but nothing is known about the virus replication levels in those tissues. A 3-year prospective hospital-based study was conducted to detect and quantify HBoV1 DNA and mRNAs in samples of the adenoids (AD), palatine tonsils (PT), nasopharyngeal secretions (NPS), and peripheral blood (PB) from patients undergoing tonsillectomy for tonsillar hypertrophy or recurrent tonsillitis. HBoV1 was detected in 25.3% of the AD samples, while the rates of detection in the PT, NPS, and PB samples were 7.2%, 10.5%, and 1.7%, respectively. The viral loads were higher in AD samples, and 27.3% of the patients with HBoV had mRNA detectable in this tissue. High viral loads and detectable mRNA in the AD were associated with HBoV1 detection in the other sample sites. The adenoids are an important site of HBoV1 replication and persistence in children with tonsillar hypertrophy. The adenoids contain high HBoV1 loads and are frequently positive for HBoV mRNA, and this is associated with the detection of HBoV1 in secretions.

A Putative Otu Domain-containing Protein 1 Deubiquitinating Enzyme Is Differentially Expressed In Thyroid Cancer And Identifies Less-aggressive Tumours.

This study aimed to identify novel biomarkers for thyroid carcinoma diagnosis and prognosis. We have constructed a human single-chain variable fragment (scFv) antibody library that was selected against tumour thyroid cells using the BRASIL method (biopanning and rapid analysis of selective interactive ligands) and phage display technology. One highly reactive clone, scFv-C1, with specific binding to papillary thyroid tumour proteins was confirmed by ELISA, which was further tested against a tissue microarray that comprised of 229 thyroid tissues, including: 110 carcinomas (38 papillary thyroid carcinomas (PTCs), 42 follicular carcinomas, 30 follicular variants of PTC), 18 normal thyroid tissues, 49 nodular goitres (NG) and 52 follicular adenomas. The scFv-C1 was able to distinguish carcinomas from benign lesions (P=0.0001) and reacted preferentially against T1 and T2 tumour stages (P=0.0108). We have further identified an OTU domain-containing protein 1, DUBA-7 deubiquitinating enzyme as the scFv-binding antigen using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. The strategy of screening and identifying a cell-surface-binding antibody against thyroid tissues was highly effective and resulted in a useful biomarker that recognises malignancy among thyroid nodules and may help identify lower-risk cases that can benefit from less-aggressive management.

Treadmill Training Increases Sirt-1 And Pgc-1 α Protein Levels And Ampk Phosphorylation In Quadriceps Of Middle-aged Rats In An Intensity-dependent Manner.

The present study investigated the effects of running at 0.8 or 1.2 km/h on inflammatory proteins (i.e., protein levels of TNF- α , IL-1 β , and NF- κ B) and metabolic proteins (i.e., protein levels of SIRT-1 and PGC-1 α , and AMPK phosphorylation) in quadriceps of rats. Male Wistar rats at 3 (young) and 18 months (middle-aged rats) of age were divided into nonexercised (NE) and exercised at 0.8 or 1.2 km/h. The rats were trained on treadmill, 50 min per day, 5 days per week, during 8 weeks. Forty-eight hours after the last training session, muscles were removed, homogenized, and analyzed using biochemical and western blot techniques. Our results showed that: (a) running at 0.8 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with NE rats; (b) these responses were lower for the inflammatory proteins and higher for the metabolic proteins in young rats compared with middle-aged rats; (c) running at 1.2 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with 0.8 km/h; (d) these responses were similar between young and middle-aged rats when trained at 1.2 km. In summary, the age-related increases in inflammatory proteins, and the age-related declines in metabolic proteins can be reversed and largely improved by treadmill training.

The Analgesic Effect Of Dipyrone In Peripheral Tissue Involves Two Different Mechanisms: Neuronal K(atp) Channel Opening And Cb(1) Receptor Activation.

Dipyrone (metamizole) is an analgesic pro-drug used to control moderate pain. It is metabolized in two major bioactive metabolites: 4-methylaminoantipyrine (4-MAA) and 4-aminoantipyrine (4-AA). The aim of this study was to investigate the participation of peripheral CB1 and CB2 cannabinoid receptors activation in the anti-hyperalgesic effect of dipyrone, 4-MAA or 4-AA. PGE2 (100ng/50µL/paw) was locally administered in the hindpaw of male Wistar rats, and the mechanical nociceptive threshold was quantified by electronic von Frey test, before and 3h after its injection. Dipyrone, 4-MAA or 4-AA was administered 30min before the von Frey test. The selective CB1 receptor antagonist AM251, CB2 receptor antagonist AM630, cGMP inhibitor ODQ or KATP channel blocker glibenclamide were administered 30min before dipyrone, 4-MAA or 4-AA. The antisense-ODN against CB1 receptor expression was intrathecally administered once a day during four consecutive days. PGE2-induced mechanical hyperalgesia was inhibited by dipyrone, 4-MAA, and 4-AA in a dose-response manner. AM251 or ODN anti-sense against neuronal CB1 receptor, but not AM630, reversed the anti-hyperalgesic effect mediated by 4-AA, but not by dipyrone or 4-MAA. On the other hand, the anti-hyperalgesic effect of dipyrone or 4-MAA was reversed by glibenclamide or ODQ. These results suggest that the activation of neuronal CB1, but not CB2 receptor, in peripheral tissue is involved in the anti-hyperalgesic effect of 4-aminoantipyrine. In addition, 4-methylaminoantipyrine mediates the anti-hyperalgesic effect by cGMP activation and KATP opening.

Synthesis And Antiproliferative Activity Of 8-hydroxyquinoline Derivatives Containing A 1,2,3-triazole Moiety.

Twelve novel 8-hydroxyquinoline derivatives were synthesized with good yields by performing copper-catalyzed Huisgen 1,3-dipolar cycloaddition (click reaction) between an 8-O-alkylated-quinoline containing a terminal alkyne and various aromatic or protected sugar azides. These compounds were evaluated in vitro for their antiproliferative activity on various cancer cell types. Protected sugar derivative 16 was the most active compound in the series, exhibiting potent antiproliferative activity and high selectivity toward ovarian cancer cells (OVCAR-03, GI50 < 0.25 μg mL(-1)); this derivative was more active than the reference drug doxorubicin (OVCAR-03, GI50 = 0.43 μg mL(-1)). In structure-activity relationship (SAR) studies, the physico-chemical parameters of the compounds were evaluated and docking calculations were performed for the α-glucosidase active site to predict the possible mechanism of action of this series of compounds.

Communication: Transient Anion States Of Phenol…(h₂o)n (n = 1, 2) Complexes: Search For Microsolvation Signatures.

We report on the shape resonance spectra of phenol-water clusters, as obtained from elastic electron scattering calculations. Our results, along with virtual orbital analysis, indicate that the well-known indirect mechanism for hydrogen elimination in the gas phase is significantly impacted on by microsolvation, due to the competition between vibronic couplings on the solute and solvent molecules. This fact suggests how relevant the solvation effects could be for the electron-driven damage of biomolecules and the biomass delignification [E. M. de Oliveira et al., Phys. Rev. A 86, 020701(R) (2012)]. We also discuss microsolvation signatures in the differential cross sections that could help to identify the solvated complexes and access the composition of gaseous admixtures of these species.

Stathmin 1, A Therapeutic Target In Esophageal Carcinoma?

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