Deteccão de diferentes microorganismos na periodontite crônica, da glicoproteína EMMPRIN (CD-147) e sua correlação com a produção de MMP-2 e MMP-9

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Expressão do transportador de monocarboxilato MCT1 e sua proteína auxiliar CD 147 em hemácias de equinos de salto

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Detecção de Periodontopatógenos, Glicoproteína Emmprin (Cd-147) e sua correlação com MMP-2 e MMP-9

Periodontitis is an infectious disease characterized by the secretion of a variety of inflammatory mediators that lead to destruction of tooth supporting tissues, including the possible loss of alveolar bone, in association with infection with multiple species of bacteria. It is estimated that more than 400 species colonize the biofilm and some oral species related to periodontal disease is present in the subgingival including P. gingivalis, T. forsythia and T. denticola. However, other organisms may be related of this disease, as Filifactor allocis and Prevotella tannerae. These microorganisms and subproducts such as endotoxins released into the extracellular lead to the stimulation of metalloproteinase inducer glycoprotein (EMMPRIN, CD-147), which stimulates the release of MMPs by host cells, like fibroblasts and endothelial cells, thus leading to tissue destruction. The objective of this study was to detect F. allocis, P. tannerae, T. denticola and the glycoprotein EMMPRIN (CD-147) and its correlation with MMP-2 and MMP-9 in subgingival fluid samples of patients with chronic periodontitis. Fluids were collected from healthy and disease subgingival sites of 20 healthy individuals before basic periodontal treatment and after of 60 days of treatment. Their DNAs were extracted and portions of the 16S gene were amplified and performed conventional PCR. For immunological analysis and quantification of EMMPRIN (CD-147), MMP-2 and MMP-9 was used ELISA-Sandwich. Results demonstrated that the disease group showed significantly high amounts of T. denticola, F. alocis and P. tannerae when compared with health sites. MMP-2 and MMP-9 were detected in high concentrations with statistically significantly reduction after periodontal treatment to MMP-2, but without correlation with EMMPRIN.

Surasky Family Papers - Accession 250 - M115 (147)

The Surasky Family Papers consists of correspondence, newspaper clippings, reminiscences, poetry, and other papers mostly photocopies. Of particular interest are a reminiscence by Esther Pinck entitled “Remembrance of Things Past”, concerned with the Jewish experience in Aiken, SC; papers related to Mina Tropp, a painter who developed a unique medium of painting with flora and who is also published poet; and letters of Judge Justine Wise Polier, well known Juvenile Court judge in New York. Collection is almost all photocopies.

The Azores Current System and the Canary Current from CTD and ADCP data

Se han eliminado páginas en blanco

Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

BACKGROUND Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. OBJECTIVES We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). METHODS First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. RESULTS Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). CONCLUSION Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.

Ms. hebr. oct. 147 - Sheʾeltot de-Rav Aḥaʼi

Vorbesitzer: Abraham Merzbacher

Ms. germ. qu. 147 - Protokollbuch der Deputation 1698 - 1700

Vorbesitzer: Johann Hieronymus Zum Jungen;

Ms. Barth. 147 - De arte bene moriendi

Vorbesitzer: Jungo Frosch; Bartholomaeusstift Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 147 - Bericht über den Stand der Publikation zur Philosophie Schopenhauers

u.a.: fehlende Anerkennung der Philosophie Schopenhauers; Johanna Schopenhauer;

Ms. Praed. 147 - De censuris ecclesiasticis

Vorbesitzer: Dominikanerkloster Frankfurt am Main;

Ms.Ff.F.Stoltze 3. 147 - Brief von Gustav Kanngießer an Friedrich Stoltze

Rückgabe geliehener Bücher, Gustav Freytag: Bilder aus der deutschen Vergangenheit

Na 1 Nachlass Max Horkheimer, 542 - Korrespondenzen mit Leo Löwenthal (p. VI 16, 147 - 341)

109 Briefe zwischen Leo Löwenthal und Max Horkheimer; 1 Brief von den Office of Strategie Services (Washington D.C.) an Leo Löwenthal, 23.10.1943; 2 Briefe von Leo Löwenthal an Frederick Pollock, August 1943; 3 Briefe zwischen Daniel Levison und Leo Löwenthal, August 1943;