Nutrient Enhanced Coastal Ocean Productivity (NECOP). Data report: CTD and hydrographic data, R/V Pelican cruise, April 3-11, 1993

The Nutrient Enhanced Coastal Ocean Productivity (NECOP) Program is a component of NOAA's Coastal Ocean Program. The central hypothesis of this research is: Anthropogenic nutrient inputs have enhanced coastal ocean productivity with subsequent impacts on coastal ocean water quality, living resource yields, and the global marine carbon cycle. The initial study area for this program is the Mississippi/Atchafalaya River Outflow and adjacent Louisiana shelf region.

~(135)La高自旋态的实验研究

利用在束γ谱实验技术 ,通过 12 8Te(10 B ,3n) 13 5La反应研究了 13 5La的高自旋态 .基于γ γ符合关系、γ射线的相对强度和各向异性度的测量结果 ,建立了 13 5La的能级纲图 .在ω≈ 0 .4 0MeV附近 ,观测到基于πh11 2 质子轨道上的负宇称带的带交叉 .比较N =78同中子素链能级结构的系统性 ,认为该带交叉是由一对h11 2 准质子发生转动顺排造成的 .在高自旋态处 ,观测到具有很强M1跃迁、Signature劈裂很小的ΔI =1负宇称带 ,根据系统性认为该带是建立在πh11 2 (νh11 2 ) 2 组态上的γ≈ - 6 0°的扁椭球形变带 .

Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.

BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1). Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. Furthermore, enhanced P-CTD cleavage was observed in both yeast and human breast cells following UV-irradiation indicating a conserved eukaryotic damage response. Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression.

Distribución y rangos preferenciales de temperatura y salinidad de los recursos pelágicos deurante el otoño de 1998. Crucero BIC Humboldt 9803-05 de Tumbes a Tacna

Describe la distribución, concentración y rangos preferenciales de temperatura y salinidad de los principales recursos pelágicos: anchoveta, sardina, jurel y caballa; y adicionalmente de la samasa por el significativo nivel de abundancia determinado durante el Crucero (otoño 1998). Para la distribución y concentración se utilizó una ecosonda científica SIMRAD EK 500 con frecuencias de 38 y 120 kHz en un rango de detección de 3,5 a 400 m de profundidad, distribuidos en nueve capas de integración. Para el muestreo acústico se utilizó una grilla sistemática paralela con una separación de 12 mn entre transectos; se realizaron en total 391 lances de pesca de arrastre pelágico para la comprobación de ecorregistros (BIC Humboldt y lanchas). Las áreas de distribución de cada recurso se determinaron mediante un programa de software de interpolación de datos. Para la determinación de los rangos preferenciales de temperatura y salinidad se utilizó un CTD y botellas Niskin hasta los 300 m de profundidad. Los análisis se realizaron a bordo por el método de inducción.

Explication de l'Exode par Nicolas de Tournai. - Fragment de la règle de s. Benoit (135).

Célestins.

Livre des Morts de Djéhoutyirydès. Egyptien 135

Suite du chapitre 141 (litanie des dieux).

Resolución N° 135 ¿La Cámara de Comercio de Bogotá tiene competencia para decidir sobre las acciones de impugnación de actas?

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