Mazag��o: A ��ltima pra��a Portuguesa no Norte de ��frica

Revista do IHA, N.4 (2007), pp.184-211

Estudo e interven����o do Foral Manuelino de Cascais: especializa����o em documentos gr��ficos

Este trabalho foi divulgado a atrav��s de: POSTER SILVA, Joana; FRAGOSO, Sara; PESSANHA, Sofia; MANSO, Marta; LONGELIN, Stephane; ESTEVES, L��lia; OLIVEIRA, Maria Jos��; PEREIRA, Lu��s; GUERRA, Mauro; CARVALHO, Maria Lu��sa; LE GAC, Agn��s; Contribution of non-invasive X-ray digital radiography and energy dispersive X-ray fluorescence to the characterization of a 1514 ��� Portuguese c��dex, European Conference on X-ray Spectrometry; Bologna, Italy, 15-20 June, 2014

Variabilit��t der mitochondrialen Genloci nt00073 und nt16519 im populationsgenetischen Vergleich : eine Untersuchung anhand von RFLP- und LightCycler-Daten

Magdeburg, Univ., Medizin. Fakult��t, Diss., 2003

Le pied �� risque: du point de vue de l'orthop��diste [The diabetic foot: the role of the orthopaedic surgeon].

Around 15% of diabetic patients will suffer from a diabetic foot ulcus and subsequent amputation. Prevention and adapted treatment of a foot at risk is important and should be carried out by a multidisciplinary team. A foot at risk needs patient training and adapted footwear. Local wound care and control of vascular status follow. In case of deterioration of the local status surgical debridement and occasionally amputation have to be considered.

El lloc teatral i el seu espai esc��nic: artialitzaci�� en William Shakespeare (c..1590-1611) : actor, empresari, dramaturg

Pensar en William Shakespeare, apropar-se a una de l'obres qu�� m��s tinta han fet c��rrer, se'ns presenta com voler trobar una agulla en un paller. Amb tot, aquest treball de recerca a volgut discernir la dramat��rgia de Shakespeare, des de l'��ptica espacial i est��tica. El seu marc, a l'Anglaterra renaixentista -ss,XVI-XVII-, ��s: l'abundosa legislaci�� -important l'Acta promulgada l'any 1572, per la reina Elisabet I-; la tipologia constructiva i formal del Lloc del Teatre, amb la formulaci�� empresarial qu�� se���n deriva; l'altre element, la participaci�� de l'espectador impl��cit. Conclusivament, com l'artialitzaci�� shakespeariana s'insereix, podem dir, 'dramatol��gicament', dins l'historiografia general del teatre.

Jean Calvin : Puissance de la Loi et limite du Pouvoir

L'��thique politique de Jean Calvin (1509-1564) est �� la fois une ��thique religieuse, inspir��e par le puissant mouvement r��formateur de Luther, et une ��thique de la Loi morale, soucieuse d'instruire un nouveau rapport au droit et �� la cit��. La mani��re m��me dont Calvin ��nonce le r��le ambig�� de l'Eglise, lieu de lib��ration mais aussi instrument de contr��le social, est r��v��latrice de sa vis��e critique et constructive, comme de ses propres limites. Reconnue dans sa distance et dans son contexte, l'��thique de Calvin en sera d'autant plus signifiante pour quiconque entend refonder l'alliance de la d��mocratie, de la la��cit�� et d'une forme de transcendance, en r��gime de m��ta-modernit��.

Chromatic pupil responses: preferential activation of the melanopsin-mediated versus outer photoreceptor-mediated pupil light reflex.

OBJECTIVE: To weight the rod-, cone-, and melanopsin-mediated activation of the retinal ganglion cells, which drive the pupil light reflex by varying the light stimulus wavelength, intensity, and duration. DESIGN: Experimental study. PARTICIPANTS: Forty-three subjects with normal eyes and 3 patients with neuroretinal visual loss. METHODS: A novel stimulus paradigm was developed using either a long wavelength (red) or short wavelength (blue) light given as a continuous Ganzfeld stimulus with stepwise increases over a 2 log-unit range. The pupillary movement before, during, and after the light stimulus was recorded in real time with an infrared illuminated video camera. MAIN OUTCOME MEASURES: The percent pupil contraction of the transient and sustained pupil response to a low- (1 cd/m(2)), medium- (10 cd/m(2)), and high-intensity (100 cd/m(2)) red- and blue-light stimulus was calculated for 1 eye of each subject. From the 43 normal eyes, median and 25th, 75th, 5th, and 95th percentile values were obtained for each stimulus condition. RESULTS: In normal eyes at lower intensities, blue light evoked much greater pupil responses compared with red light when matched for photopic luminance. The transient pupil contraction was generally greater than the sustained contraction, and this disparity was greatest at the lowest light intensity and least apparent with bright (100 cd/m(2)) blue light. A patient with primarily rod dysfunction (nonrecordable scotopic electroretinogram) showed significantly reduced pupil responses to blue light at lower intensities. A patient with achromatopsia and an almost normal visual field showed selective reduction of the pupil response to red-light stimulation. A patient with ganglion cell dysfunction owing to anterior ischemic optic neuropathy demonstrated global loss of pupil responses to red and blue light in the affected eye. CONCLUSIONS: Pupil responses that differ as a function of light intensity and wavelength support the hypothesis that selected stimulus conditions can produce pupil responses that reflect phototransduction primarily mediated by rods, cones, or melanopsin. Use of chromatic pupil responses may be a novel way to diagnose and monitor diseases affecting either the outer or inner retina.

CD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibility

Background: A functional polymorphism located at 21 from the start codon of the CD40 gene, rs1883832, was previously reported to disrupt a Kozak sequence essential for translation. It has been consistently associated with Graves��� disease risk in populations of different ethnicity and genetic proxies of this variant evaluated in genome-wide association studies have shown evidence of an effect in rheumatoid arthritis and multiple sclerosis (MS) susceptibility. However, the protective allele associated with Graves��� disease or rheumatoid arthritis has shown a risk role in MS, an effect that we aimed to replicate in the present work. We hypothesized that this functional polymorphism might also show an association with other complex autoimmune condition such as inflammatory bowel disease, given the CD40 overexpression previously observed in Crohn���s disease (CD) lesions. Methodology: Genotyping of rs1883832C.T was performed in 1564 MS, 1102 CD and 969 ulcerative colitis (UC) Spanish patients and in 2948 ethnically matched controls by TaqMan chemistry. Principal Findings: The observed effect of the minor allele rs1883832T was replicated in our independent Spanish MS cohort [p= 0.025; OR (95% CI)= 1.12 (1.01���1.23)]. The frequency of the minor allele was also significantly higher in CD patients than in controls [p= 0.002; OR (95% CI)= 1.19 (1.06���1.33)]. This increased predisposition was not detected in UC patients [p= 0.5; OR (95% CI)= 1.04 (0.93���1.17)]. Conclusion: The impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditions

Can vouchers deliver? An evaluation of subsidies for maternal health care in Cambodia

OBJECTIVE: To evaluate the effect of vouchers for maternity care in public health-care facilities on the utilization of maternal health-care services in Cambodia. METHODS: The study involved data from the 2010 Cambodian Demographic and Health Survey, which covered births between 2005 and 2010. The effect of voucher schemes, first implemented in 2007, on the utilization of maternal health-care services was quantified using a difference-in-differences method that compared changes in utilization in districts with voucher schemes with changes in districts without them. FINDINGS: Overall, voucher schemes were associated with an increase of 10.1 percentage points (pp) in the probability of delivery in a public health-care facility; among women from the poorest 40% of households, the increase was 15.6 pp. Vouchers were responsible for about one fifth of the increase observed in institutional deliveries in districts with schemes. Universal voucher schemes had a larger effect on the probability of delivery in a public facility than schemes targeting the poorest women. Both types of schemes increased the probability of receiving postnatal care, but the increase was significant only for non-poor women. Universal, but not targeted, voucher schemes significantly increased the probability of receiving antenatal care. CONCLUSION: Voucher schemes increased deliveries in health centres and, to a lesser extent, improved antenatal and postnatal care. However, schemes that targeted poorer women did not appear to be efficient since these women were more likely than less poor women to be encouraged to give birth in a public health-care facility, even with universal voucher schemes.

Validation and reproducibility of a semi-quantitative Food Frequency Questionnaire for use in elderly Swiss women.

OBJECTIVE: The principal aim of this study was to develop a Swiss Food Frequency Questionnaire (FFQ) for the elderly population for use in a study to investigate the influence of nutritional factors on bone health. The secondary aim was to assess its validity and both short-term and long-term reproducibility. DESIGN: A 4-day weighed record (4 d WR) was applied to 51 randomly selected women of a mean age of 80.3 years. Subsequently, a detailed FFQ was developed, cross-validated against a further 44 4-d WR, and the short- (1 month, n = 15) and long-term (12 months, n = 14) reproducibility examined. SETTING: French speaking part of Switzerland. SUBJECTS: The subjects were randomly selected women recruited from the Swiss Evaluation of the Methods of Measurement of Osteoporotic Fracture cohort study. RESULTS: Mean energy intakes by 4-d WR and FFQ showed no significant difference [1564.9 kcal (SD 351.1); 1641.3 kcal (SD 523.2) respectively]. Mean crude nutrient intakes were also similar (with nonsignifcant P-values examining the differences in intake) and ranged from 0.13 (potassium) to 0.48 (magnesium). Similar results were found in the reproducibility studies. CONCLUSION: These findings provide evidence that this FFQ adequately estimates nutrient intakes and can be used to rank individuals within distributions of intake in specific populations.