Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum

The low-molecular-mass rhoptry complex of Plasmodium falciparum consists of three proteins, rhoptry-associated protein 1 (RAP1), RAP2, and RAP3. The genes encoding RAP1 and RAP2 are known; however, the RAP3 gene has not been identified. In this study we identify the RAP3 gene from the P. falciparum genome database and show that this protein is part of the low-molecular-mass rhoptry complex. Disruption of RAP3 demonstrated that it is not essential for merozoite invasion, probably because RAP2 can complement the loss of RAP3. RAP3 has homology with RAP2, and the genes are encoded on chromosome 5 in a head-to-tail fashion. Analysis of the genome databases has identified homologous genes in all Plasmodium spp., suggesting that this protein plays a role in merozoite invasion. The region surrounding the RAP3 homologue in the Plasmodium yoelii genome is syntenic with the same region in P. falciparum; however, there is a single gene. Phylogenetic comparison of the RAP2/3 protein family from Plasmodium spp. suggests that the RAP2/3 duplication occurred after divergence of these parasite species.

Australia's health 1992 : the third biennial report of the Australian Institute of Health and Welfare

Australia's Health is the most comprehensive and authoritative source of national information on health in Australia. Australia's Health is published mid-year in even-numbered years and provides national statistics and related information that form a record of health status, service provision and expenditure in Australia.

The third debate and the nagging Afghan-Pakistan question

For a war that has gone on for more than a decade, cost the American taxpayer some US$500 billion, claimed the lives of more than two thousand GIs and inflicted many more thousands of wounded, the conflict in Afghanistan has barely got any mention during the presidential campaign.

Our place in the Asian century: Southeast Asia as ‘The Third Way’

The report, for Asialink at the University of Melbourne, reports the findings of the Asialink Commission, which examined Australia's relations with Southeast Asia. It argues that, at a time of shifting power relations in the Asia-Pacific region, Australia take a more multilateral approach by orienting its foreign and trade policies towards Southeast Asia. By committing more attention to the Southeast Asia region, Australia will enhance its relationships with the region's two principal powers, the United States and China.

'Scott's aired a couple of things' : back to back theatre rehearse Ganesh versus the third Reich

 This chapter tracks the creation of Back to Back Theatre’s 2011 performance, Ganesh Versus the Third Reich, based on first-hand observation of the final stages in devising and refining the work. Ganesh traces two parallel narrative strands – that of an imagined journey of the Hindu God into the dark heart of Nazi Germany to reclaim the sacred Hindu symbol of the swastika, and the narrative which constantly threatens to engulf the Ganesh story – the fraught relations between a group of disabled artists and their non-disabled director as they negotiate the process of making the work.

The focus of this chapter is the development of a single scene from the performance work, Ganesh Versus the Third Reich, tracing it’s evolution through periods of creative development and rehearsal. The stark contrast between the working practices observed on the studio floor and the brutally knowing and parodic representation of power relations in rehearsal seen in the performance work testifies to the peculiar and productive self-reflexivity that generates the work of Back To Back Theatre. An account and analysis of both real and fictional rehearsals reveal how Back to Back’s creative processes position members of the ensemble “perceived to have intellectual disabilities” as entirely legitimate professional artists, while claiming the authority of ‘outsider artists’ to challenge perceptions and representations of disability.

Medulloblastoma Down Under 2013 : a report from the third annual meeting of the International Medulloblastoma Working Group.

Medulloblastoma is curable in approximately 70% of patients. Over the past decade, progress in improving survival using conventional therapies has stalled, resulting in reduced quality of life due to treatment-related side effects, which are a major concern in survivors. The vast amount of genomic and molecular data generated over the last 5-10 years encourages optimism that improved risk stratification and new molecular targets will improve outcomes. It is now clear that medulloblastoma is not a single-disease entity, but instead consists of at least four distinct molecular subgroups: WNT/Wingless, Sonic Hedgehog, Group 3, and Group 4. The Medulloblastoma Down Under 2013 meeting, which convened at Bunker Bay, Australia, brought together 50 leading clinicians and scientists. The 2-day agenda included focused sessions on pathology and molecular stratification, genomics and mouse models, high-throughput drug screening, and clinical trial design. The meeting established a global action plan to translate novel biologic insights and drug targeting into treatment regimens to improve outcomes. A consensus was reached in several key areas, with the most important being that a novel classification scheme for medulloblastoma based on the four molecular subgroups, as well as histopathologic features, should be presented for consideration in the upcoming fifth edition of the World Health Organization's classification of tumours of the central nervous system. Three other notable areas of agreement were as follows: (1) to establish a central repository of annotated mouse models that are readily accessible and freely available to the international research community; (2) to institute common eligibility criteria between the Children's Oncology Group and the International Society of Paediatric Oncology Europe and initiate joint or parallel clinical trials; (3) to share preliminary high-throughput screening data across discovery labs to hasten the development of novel therapeutics. Medulloblastoma Down Under 2013 was an effective forum for meaningful discussion, which resulted in enhancing international collaborative clinical and translational research of this rare disease. This template could be applied to other fields to devise global action plans addressing all aspects of a disease, from improved disease classification, treatment stratification, and drug targeting to superior treatment regimens to be assessed in cooperative international clinical trials.

The third space: The poetry of Sudesh Mishra & the paintings of John Forrest

This book consists of two chapters that document and analyse the context and development of a collaboration between two writers, a poet and a painter, 33 poems and 33 paintings. The poems and paintings are placed in a dialogical relationship with each other. The book attempts to do more than present poetry and paintings serving merely as an illustration of each other. Instead the authors/artists have experimented with how each art-form can bring further significance to another and make new meaning. The two chapters and introduction set up for the viewer a means of exploring a novel form of making meaning. Furthermore these chapters discuss aesthetic, philosophical, historical and political questions endemic not only to the selected art and poetry but to questions governing creative art processes. In this sense it deals with what we have termed 'a third space'.

Introduction (to the book the Third Space)

This introduction sets up the nature of the arts discourse and arts practice involved in the creation of the book The Third Space: The Poetry of Sudesh Mishra and the Paintings of John Forrest

The third space : Metaphor and the disturbing observer

This book is a collaboration with a poet,a painter and two literary critics/philosophers. It is an investigation into aesthetics and examines and presents the possibilities for a poet and a painter in going beyond appropriating words and images from practitioners within their respective verbal and visual fields. In this book, the poet and the painter have been placed in a dialogic position to each other. This book attempts to create further meaning in the positioning of poems alongside paintings. It is a book about the processes of creativity, the making of art, the irresolvable dilemma of attempting to create from a world from which one cannot separate. The subject matter deals with art processes when attempting to re-discover lost identities with a focus on historical, psychological and political contexts