Influence of total and specific IgE, serum tryptase, and age on severity of allergic reactions to Hymenoptera stings

The aim of this study was to analyze the influence of total serum IgE and other potential risk factors on severity of systemic allergic Hymenoptera sting reactions.

Use of an indirect enzyme-linked immunosorbent assay for detection of antibodies in sheep naturally infected with Salmonella Abortusovis

An indirect enzyme-linked immunosorbent assay (ELISA) was modified and validated to detect antibodies against Salmonella Abortusovis in naturally infected sheep. The ELISA was validated with 44 positive and 45 negative control serum samples. Compared with the immunoblot, the sensitivity and specificity of the assay were 98% and 100%, respectively. To follow antibody levels over time, samples from 12 infected ewes were collected at 1, 3, and 10 months after abortion. All animals showed antibody levels above the cutoff value throughout the observation period. One and 3 months after abortion, high antibody levels could be detected in all but one animal, whereas after 10 months, 9 animals had markedly lower but still positive antibody levels. The test characteristics and evidence for the persistence of detectable antibody levels in all infected animals for up to 10 months indicates that the ELISA can be used for herd surveillance testing.

Clinical and immunologic effects of H1 antihistamine preventive medication during honeybee venom immunotherapy

BACKGROUND: H1 antihistamines increase safety during allergen-specific immunotherapy and might influence the outcome because of immunoregulatory effects. OBJECTIVE: We sought to analyze the influence of 5 mg of levocetirizine (LC) on the safety, efficacy, and immunologic effects of ultrarush honeybee venom immunotherapy (BVIT). METHOD: In a double-blind, placebo-controlled study 54 patients with honeybee venom allergy received LC or placebo from 2 days before BVIT to day 21. Side effects during dose increase and systemic allergic reactions (SARs) to a sting challenge after 120 days were analyzed. Allergen-specific immune response was investigated in skin, serum, and allergen-stimulated T-cell cultures. RESULTS: Side effects were significantly more frequent in patients receiving placebo. Four patients receiving placebo dropped out because of side effects. SARs to the sting challenge occurred in 8 patients (6 in the LC group and 2 in the placebo group). Seven SARs were only cutaneous, and 1 in the placebo group was also respiratory. Difference of SARs caused by the sting challenge was insignificant. Specific IgG levels increased significantly in both groups. Major allergen phospholipase A(2)-stimulated T cells from both groups showed a slightly decreased proliferation. The decrease in IFN-gamma and IL-13 levels with placebo was not prominent with LC, whereas IL-10 levels showed a significant increase in the LC group only. Decreased histamine receptor (HR)1/HR2 ratio in allergen-specific T cells on day 21 in the placebo group was prevented by LC. CONCLUSIONS: LC reduces side effects during dose increase without influencing the efficacy of BVIT. LC modulates the natural course of allergen-specific immune response and affects the expression of HRs and cytokine production by allergen-specific T cells.

Soziale Dienste, Schule und zivilgesellschaftliches Klima

In an international perspective cooperation between social services and school has a long tradition. In the German speaking countries we can recognize a historical distance or gap between school and “social pedagogy”, but despite this tradition new forms of cooperation are arising since the last few years. This tendency is part of the development of European societies into “knowledge-based societies” where knowledge and cultural capital are becoming ever stricter criteria for participation in society. This puts particular pressure on those adolescents who threaten to fail in the positional competition for educational qualifications. And it tends to the reproduction and reinforcing of social inequalities due to inequalities in education. For that reason in the article the development of school related social services in different European countries is investigated and it is shown that the increasing pressure to qualification and selection in school creates various problems of integration. Social dimensions of education are pointed out delivering starting points for the cooperation of social services in school and opening opportunities for productive forms of coping with differences between family background, informal social environment and educational milieu in school. Particular attention is paid to differences in socio cultural habits, in socio economical opportunities and in collective practices of interaction. A central focus in the contribution is the orientation towards a participative civil society climate relevant for the interaction between teachers and pupils and between professionals and addressees of social services as well. It is a task of future research in school related social services to analyse their institutional structure and their practices of professional interaction and to find out by European and international comparison in which way social services can contribute to the establishing of a participative civil society climate in school.

Organisational and methodical aspects of drug and addiction prevention among young people. Developments in the Ukraine, in Germany, Spain and Russia (Project Description)

From october 2000 to march 2003 the project has been coordinated by the institute of social work and welfare studies of the TU Dresden and financed by the European Commission (INCO-COPERNICUS-Programme). It was an international cooperation between the TU Dresden (Germany), the University of Internal Affairs and the National Technical University in Kharkiv (Ukraine), the research institute AREA in Valenciá (Spain) and the Belgorod Juridical Institute of the Ministry of Internal Affairs (Russia) which was established for improving the knowledge base of drug prevention activities by the East European partners. The overall aim of the project was the analysis and elaboration of approaches to drug and addiction prevention. Under consideration of the specific conditions within the East-European countries this work should contribute to the development of pluralistic approaches towards health promotion which are embedded into an intercultural, European horizon.

Canciones que cuentan historias

La música en la clase de inglés ha tenido siempre un rol muy importante. Estudios sobre el uso de la música en estas clases han demostrado que escuchar canciones en el aula resulta una experiencia agradable que permite a los alumnos adquirir la lengua extranjera de un modo placentero y significativo. Mediante las canciones podemos exponer a los alumnos a usos reales de la lengua extranjera, donde vocabulario y estructuras gramaticales cobran sentido al estar relacionadas a un determinado contexto de uso. Las historias que cuentan las canciones lograrán cautivar aún más la atención de nuestros alumnos que si solo los exponemos a los textos frecuentemente usados en la clase de ILE. En este trabajo presentaremos una metodología práctica para enseñar y explotar los elementos lingüístico-literarios, socio-culturales y musicales de las canciones. Esto lo ejemplificaremos a través de una secuencia didáctica utilizando la canción "Moon over Bourbon Street" del cantante y compositor Sting

Canciones que cuentan historias

La música en la clase de inglés ha tenido siempre un rol muy importante. Estudios sobre el uso de la música en estas clases han demostrado que escuchar canciones en el aula resulta una experiencia agradable que permite a los alumnos adquirir la lengua extranjera de un modo placentero y significativo. Mediante las canciones podemos exponer a los alumnos a usos reales de la lengua extranjera, donde vocabulario y estructuras gramaticales cobran sentido al estar relacionadas a un determinado contexto de uso. Las historias que cuentan las canciones lograrán cautivar aún más la atención de nuestros alumnos que si solo los exponemos a los textos frecuentemente usados en la clase de ILE. En este trabajo presentaremos una metodología práctica para enseñar y explotar los elementos lingüístico-literarios, socio-culturales y musicales de las canciones. Esto lo ejemplificaremos a través de una secuencia didáctica utilizando la canción "Moon over Bourbon Street" del cantante y compositor Sting

Canciones que cuentan historias

La música en la clase de inglés ha tenido siempre un rol muy importante. Estudios sobre el uso de la música en estas clases han demostrado que escuchar canciones en el aula resulta una experiencia agradable que permite a los alumnos adquirir la lengua extranjera de un modo placentero y significativo. Mediante las canciones podemos exponer a los alumnos a usos reales de la lengua extranjera, donde vocabulario y estructuras gramaticales cobran sentido al estar relacionadas a un determinado contexto de uso. Las historias que cuentan las canciones lograrán cautivar aún más la atención de nuestros alumnos que si solo los exponemos a los textos frecuentemente usados en la clase de ILE. En este trabajo presentaremos una metodología práctica para enseñar y explotar los elementos lingüístico-literarios, socio-culturales y musicales de las canciones. Esto lo ejemplificaremos a través de una secuencia didáctica utilizando la canción "Moon over Bourbon Street" del cantante y compositor Sting

...Un-natural history, or Myths of ancient science; being a collection of curious tracts on the basilisk, unicorn, phoenix, behemoth or leviathan, dragon, giant spider, tarantula, chameleons, satyrs, homines caudati, &e.,

"This edition is limited to 275 small paper copies, and 75 large paper copies."

The works of the Right Reverend Father in God, Ezekiel Hopkins...now first collected.

I. Account of former editions of Bishop Hopkins's works. Account of the present edition. Life of Bishop Hopkins. Critical remarks on the author's writings. The Vanity of the world. A practical exposition on the Lord's prayer. A catechistical exposition on the Lord's prayer. Exposition on the Ten commandments.--II. Discourses on the law. Discourses concerning sin. The doctrine of the two covenants. The doctrine of the two sacraments. The nature and necessity of regeneration.--III. The all-sufficiency of Christ to save sinners. The excellency of heavenly treasures. Practical Christianity, in working out our own salvation. The assurance of heaven and salvation, a powerful motive to serve God with fear. On glorifying God in His attributes. The almost-Christian discovered. On the nature, corruption, and renewing of the conscience. The great duty of mortification.--IV. Death disarmed of its sting; from several considerations. Miscellaneous sermons. Index of texts illustrated.

The works of Ezekiel Hopkins : successively bishop of Raphoe and Derry /

v.1. Memoir of the author, and expositions of the Lord's prayer and the decalogue.--v.2. Discourses concerning sin, the two covenants, the two sacraments and practical religion.--v.3. Death disarmed of its sting and miscellaneous sermons.

Clinical effects of stings by sponges of the genus Tedania and a review of sponge stings worldwide

Contact with sponges (Phylum Porifera) usually results in minimal effects or abrasions, except for species that produce crinitoxins and can cause irritation and dermatitis. There are few reports of sponge stings, mainly in divers or collectors. We report a group of sponge stings from handling flame red/orange sponges on the beach, confirmed to be Tedania anhelans in five cases. All seven patients suffered immediate effects ranging from mild to severe pain, and local inflammation. A 38-year-old female and three children had delayed skin involvement including itchiness, pain, swelling and redness. Blistering and desquamation occurred in the female adult and limited desquamation in one child. Similar delayed effects have been reported in Tedania spp. stings previously. (c) 2005 Elsevier Ltd. All rights reserved.

Logics of marginalisation in health and social care reform:integration, choice, and provider-blind provision

The period 2010–2013 was a time of far-reaching structural reforms of the National Health Service in England. Of particular interest in this paper is the way in which radical critiques of the reform process were marginalised by pragmatic concerns about how to maintain the market-competition thrust of the reforms while avoiding potential fragmentation. We draw on the Essex school of political discourse theory and develop a ‘nodal’ analytical framework to argue that widespread and repeated appeals to a narrative of choice-based integrated care served to take the fragmentation ‘sting’ out of radical critiques of the pro-competition reform process. This served to marginalise alternative visions of health and social care, and to pre-empt the contestation of a key norm in the provision of health care that is closely associated with the notions of ‘any willing provider’ and ‘any qualified provider’: provider-blind provision.

Temporal differences across a bio-geographical boundary reveal slow response of sub-littoral benthos to climate change

The English Channel is located at the biogeographical boundary between the northern Boreal and southern Lusitanian biozones and therefore represents an important area to study the effects of global warming on marine organisms. While the consequences of climatic change in the western English Channel have been relatively well documented for fish, plankton and inter-tidal benthic communities, data highlighting the same effects on the distribution of sub-littoral benthic organisms does, to date, not exist. The present study resurveyed a subset of sites originally surveyed from 1958 to 1959 along the UK coast of the English Channel. The main aims of this resurvey were to describe the present status of benthic communities and to investigate potential temporal changes, in particular distributional changes in western stenothermal ‘cold’ water and southern Lusitanian ‘warm’ water species. The increase in water temperature observed since the historic survey was predicted to have caused a contraction in the distribution of cold water species and an extension in the distribution of warm water species. The temporal comparison did not show any clear broad-scale distributional changes in benthic communities consistent with these predictions. Nevertheless, 2 warm water species, the sting winkle Ocenebra erinacea and the introduced American slipper limpet Crepidula fornicata, did show range extensions and increased occurrence, possibly related to climatic warming. Similarly, warm water species previously not recorded by the historic survey were found. The absence of broad-scale temporal differences in sub-tidal communities in response to climatic warming has been reported for other areas and may indicate that these communities respond far more slowly to environmental changes compared to plankton, fish and inter-tidal organisms.

Temporal differences across a bio-geographical boundary reveal slow response of sub-littoral benthos to climate change

The English Channel is located at the biogeographical boundary between the northern Boreal and southern Lusitanian biozones and therefore represents an important area to study the effects of global warming on marine organisms. While the consequences of climatic change in the western English Channel have been relatively well documented for fish, plankton and inter-tidal benthic communities, data highlighting the same effects on the distribution of sub-littoral benthic organisms does, to date, not exist. The present study resurveyed a subset of sites originally surveyed from 1958 to 1959 along the UK coast of the English Channel. The main aims of this resurvey were to describe the present status of benthic communities and to investigate potential temporal changes, in particular distributional changes in western stenothermal ‘cold’ water and southern Lusitanian ‘warm’ water species. The increase in water temperature observed since the historic survey was predicted to have caused a contraction in the distribution of cold water species and an extension in the distribution of warm water species. The temporal comparison did not show any clear broad-scale distributional changes in benthic communities consistent with these predictions. Nevertheless, 2 warm water species, the sting winkle Ocenebra erinacea and the introduced American slipper limpet Crepidula fornicata, did show range extensions and increased occurrence, possibly related to climatic warming. Similarly, warm water species previously not recorded by the historic survey were found. The absence of broad-scale temporal differences in sub-tidal communities in response to climatic warming has been reported for other areas and may indicate that these communities respond far more slowly to environmental changes compared to plankton, fish and inter-tidal organisms.